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Hereditary factors in basal cell carcinoma of the skin: a population-based cohort study in twins.

https://arctichealth.org/en/permalink/ahliterature203764
Source
Br J Cancer. 1998 Dec;78(11):1516-20
Publication Type
Article
Date
Dec-1998
Author
T. Milán
J. Kaprio
P K Verkasalo
C T Jansén
L. Teppo
M. Koskenvuo
Author Affiliation
Department of Public Health, University of Turku, Finland.
Source
Br J Cancer. 1998 Dec;78(11):1516-20
Date
Dec-1998
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Carcinoma, Basal Cell - epidemiology - genetics
Cohort Studies
Diseases in Twins - epidemiology - genetics
Female
Finland - epidemiology
Humans
Male
Prospective Studies
Retrospective Studies
Sex Distribution
Skin Neoplasms - epidemiology - genetics
Twins, Dizygotic - statistics & numerical data
Twins, Monozygotic - statistics & numerical data
Abstract
The contribution of hereditary factors in basal cell carcinoma of the skin has not been well defined at the population level. We aimed to assess the hereditary component in basal cell carcinoma by comparing its occurrence in monozygotic and dizygotic twin pairs. The Finnish Twin Cohort, comprising 12,941 adult, like-sex twin pairs with established zygosity and resident in Finland in 1975, was linked with the Finnish Cancer Registry. We identified 335 twin pairs in which at least one twin had basal cell carcinoma diagnosed between 1953 and 1996. Standardized incidence ratios, concordances, tetrachoric correlations and pairwise relative risks were computed by standard methods. Components of variance in liability were estimated by structural equation modelling. There was an elevated risk of basal cell carcinoma for the co-twin of a diseased twin, but no difference in risk by zygosity. During the prospective follow-up in 1976-96, the probandwise concordance was 7.7% in monozygotic and 7.0% in dizygotic pairs. Model fitting indicated that genetic factors were not needed to account for the distribution of basal cell carcinoma in twin pairs. These results confirm the major role of environmental factors in the aetiology of basal cell carcinoma.
Notes
Cites: Prog Clin Biol Res. 1978;24 Pt B:179-84569306
Cites: Cancer. 1979 Dec;44(6):2294-305509397
Cites: Arch Dermatol. 1980 Apr;116(4):454-67369779
Cites: Int J Dermatol. 1985 Sep;24(7):444-64055198
Cites: Arch Dermatol. 1987 Feb;123(2):241-503545087
Cites: Behav Genet. 1989 Jan;19(1):9-352712816
Cites: Photodermatol. 1989 Jun;6(3):110-72762201
Cites: Int J Dermatol. 1989 Sep;28(7):445-502777443
Cites: J Intern Med. 1992 Jan;231(1):67-721732401
Cites: Cell. 1996 Jun 14;85(6):841-518681379
Cites: J Natl Cancer Inst. 1997 Feb 19;89(4):287-939048832
Cites: Science. 1997 May 2;276(5313):817-219115210
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Cites: Bull Cancer. 1978;65(2):169-82212144
Comment In: Br J Cancer. 2000 Jan;82(1):247-910638998
PubMed ID
9836487 View in PubMed
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Sleeptalking in twins: epidemiology and psychiatric comorbidity.

https://arctichealth.org/en/permalink/ahliterature204061
Source
Behav Genet. 1998 Jul;28(4):289-98
Publication Type
Article
Date
Jul-1998
Author
C. Hublin
J. Kaprio
M. Partinen
M. Koskenvuo
Author Affiliation
Department of Public Health, University of Helsinki, Finland. christer.hublin@hnrc.fl
Source
Behav Genet. 1998 Jul;28(4):289-98
Date
Jul-1998
Language
English
Publication Type
Article
Keywords
Adult
Child
Cohort Studies
Comorbidity
Female
Finland - epidemiology
Humans
Male
Mental Disorders - epidemiology
Middle Aged
Models, Genetic
Prevalence
Retrospective Studies
Sleep Disorders - epidemiology - genetics
Speech - physiology
Statistics as Topic
Abstract
Sleeptalking is usually benign but chronic cases in adults may relate to psychopathology. We hypothesize substantial genetic influences in the liability to sleeptalking and an association between sleeptalking and psychiatric disorders. In 1990 a questionnaire sent to the Finnish Twin Cohort yielded responses from 1298 monozygotic and 2419 dizygotic twin pairs aged 33-60 years. We used structural equation modelling to estimate genetic and environmental components of variance in the liability to sleeptalking. Register data on hospitalization and long-term antipsychotic medication were used to assess psychiatric comorbidity. The occurrence of childhood and adult sleeptalking was highly correlated. A gender difference was only seen in adults, with sleeptalking being more common in males than in females. The proportion of total phenotypic variance in liability to sleeptalking attributed to genetic influences in childhood sleeptalking was 54% (95% CI, 44-62%) in males and 51% (43-58%) in females, and for adults it was 37% (27-46%) among males and 48% (40-56%) among females. An association with psychiatric comorbidity was found only in adult sleeptalking, and it was highest in those with adult-onset sleeptalking (odds ratio, 3.77; 95% CI, 2.32-6.17). Sleeptalking is quite a persistent trait, also being common in adults. There are substantial genetic effects on sleeptalking both in childhood and as adults, which appear to be highly correlated. In adults psychiatric comorbidity is about twice as common in those with frequent sleeptalking, compared to those with infrequent or no sleeptalking, but most cases of sleeptalking are not associated with serious psychopathology.
PubMed ID
9803021 View in PubMed
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Hay fever--a Finnish nationwide study of adolescent twins and their parents.

https://arctichealth.org/en/permalink/ahliterature204165
Source
Allergy. 1998 Sep;53(9):885-90
Publication Type
Article
Date
Sep-1998
Author
M. Räsänen
T. Laitinen
J. Kaprio
M. Koskenvuo
L A Laitinen
Author Affiliation
Department of Medicine, Helsinki University Central Hospital, Finland.
Source
Allergy. 1998 Sep;53(9):885-90
Date
Sep-1998
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Diseases in Twins - epidemiology - genetics
Family Health
Female
Finland - epidemiology
Health Surveys
Humans
Incidence
Male
Parents
Questionnaires
Rhinitis, Allergic, Seasonal - epidemiology - genetics
Risk factors
Twins, Dizygotic - genetics
Twins, Monozygotic - genetics
Abstract
Like other atopic diseases, hay fever is known to cluster in families. This clustering is due either to effects of a shared family environment or to genetic inheritance. By comparing the occurrence of hay fever among monozygous (MZ) and dizygous (DZ) twin pairs, we were able to estimate the contribution of genetic and environmental factors in the development of hay fever.
A questionnaire mailed to a nationwide sample of 2483 families with 16-year-old twins furnished data for the cumulative incidence of physician-diagnosed hay fever among these adolescents and their parents.
Among the 1765 twin pairs with data available for analysis, hay fever was reported for 14.1% of boys (95% CI=12.4-15.8%) and 10.0% of girls (95% CI=8.6-11.4%). The MZ twin pairs (probandwise concordance rate=60.3%, 95% CI =52-68%) were significantly more concordant for hay fever than were DZ twin pairs (31.5%, 95% CI=26-36%). Genetic factors accounted for 74-82% of the interindividual variability in liability to hay fever, variation in shared family environment for 7% at most, and unique (individual) environment for 18%.
Familial occurrence of hay fever is mainly due to genes predisposing to the trait. Environmental exposures shared in common by family members but varying between families appear to account for at most a modest proportion of the variability in risk of developing hay fever.
PubMed ID
9788691 View in PubMed
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Consistency and change in patterns of social drinking: a 6-year follow-up of the Finnish Twin Cohort.

https://arctichealth.org/en/permalink/ahliterature224022
Source
Alcohol Clin Exp Res. 1992 Apr;16(2):234-40
Publication Type
Article
Date
Apr-1992
Author
J. Kaprio
R. Viken
M. Koskenvuo
K. Romanov
R J Rose
Author Affiliation
Department of Public Health, University of Helsinki, Finland.
Source
Alcohol Clin Exp Res. 1992 Apr;16(2):234-40
Date
Apr-1992
Language
English
Publication Type
Article
Keywords
Adult
Alcohol Drinking - genetics - psychology
Alcoholism - genetics - psychology
Cohort Studies
Diseases in Twins - genetics - psychology
Female
Finland
Follow-Up Studies
Humans
Individuality
Longitudinal Studies
Male
Models, Genetic
Phenotype
Risk factors
Social Environment
Twins, Dizygotic - genetics - psychology
Twins, Monozygotic - genetics - psychology
Abstract
In 1975 and again in 1981, all adult twins in the population-based Finnish Twin Cohort were administered postal questionnaires yielding data on self-reported frequency and quantity of alcohol use. The longitudinal results provide information on the age-to-age stability of social drinking patterns among 13,404 (twin) individuals aged 18 to 43 at baseline; model-fitting the cross-temporal consistency of the twins' reported alcohol use yields unique estimates of the contribution of genetic and environmental factors to their individual age-to-age stabilities. Mean consumption levels did not change between 1975 and 1981. Patterns of social drinking were more stable in older (aged 24-43 at baseline) than younger (aged 18-23 at baseline) adult twins, and were more stable among men than women. Heritabilities were significant at both baseline and follow-up for all three alcohol measures in both genders and both age groups, with a median magnitude of 0.48. Both longitudinal genetic and environmental covariances were significant, and both were generally higher among older pairs. Genetic covariances (median magnitude = 0.68) were significantly higher than environmental covariances (median = 0.36). Analyses of absolute changes in alcohol use revealed heritable influences on the disposition to change. We conclude that genes contribute to both consistency and change in patterns of alcohol use from early to midadulthood.
PubMed ID
1590545 View in PubMed
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Evidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: a follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish Twin Cohort Study.

https://arctichealth.org/en/permalink/ahliterature144153
Source
Diabetologia. 2010 Jul;53(7):1314-21
Publication Type
Article
Date
Jul-2010
Author
M. Lehtovirta
K H Pietiläinen
E. Levälahti
K. Heikkilä
L. Groop
K. Silventoinen
M. Koskenvuo
J. Kaprio
Author Affiliation
Department of Public Health, University of Helsinki, P.O. Box 41, FIN-00014, Helsinki, Finland. mikko.lehtovirta@helsinki.fi
Source
Diabetologia. 2010 Jul;53(7):1314-21
Date
Jul-2010
Language
English
Publication Type
Article
Keywords
Adult
Body mass index
Cohort Studies
Diabetes Mellitus, Type 2 - genetics
Female
Finland
Genetic Variation
Humans
Male
Middle Aged
Proportional Hazards Models
Twins, Dizygotic - genetics
Twins, Monozygotic - genetics
Abstract
We investigated whether BMI predicts type 2 diabetes in twins and to what extent that is explained by common genetic factors.
This was a population-based twin cohort study. Monozygotic (n = 4,076) and dizygotic (n = 9,109) non-diabetic twin pairs born before 1958 answered a questionnaire in 1975, from which BMI was obtained. Information on incident cases of diabetes was obtained by linkage to nationwide registers until 2005.
Altogether, 1,332 twins (6.3% of men, 5.1% of women) developed type 2 diabetes. The HR for type 2 diabetes increased monotonically with a mean of 1.22 (95% CI 1.20-1.24) per BMI unit and of 1.97 (95% CI 1.87-2.08) per SD of BMI. The HRs for lean, overweight, obese and morbidly obese participants were 0.59, 2.96, 6.80 and 13.64 as compared with normal weight participants. Model heritability estimates for bivariate variance due to an additive genetic component and non-shared environmental component were 75% (men) and 71% (women) for BMI, and 73% and 64%, respectively for type 2 diabetes. The correlations between genetic variance components (r (g)) indicated that one fifth of the covariance of BMI and type 2 diabetes was due to shared genetic influences. Although the mean monozygotic concordance for type 2 diabetes was approximately twice the dizygotic one, age of onset of diabetes within twin pair members varied greatly, irrespective of zygosity.
A 28-year follow-up of adult Finnish twins showed that despite high trait heritability estimates, only a fraction of covariation in BMI and incident type 2 diabetes was of genetic origin.
PubMed ID
20401462 View in PubMed
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Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland.

https://arctichealth.org/en/permalink/ahliterature222787
Source
Diabetologia. 1992 Nov;35(11):1060-7
Publication Type
Article
Date
Nov-1992
Author
J. Kaprio
J. Tuomilehto
M. Koskenvuo
K. Romanov
A. Reunanen
J. Eriksson
J. Stengård
Y A Kesäniemi
Author Affiliation
Department of Public Health, University of Helsinki, Finland.
Source
Diabetologia. 1992 Nov;35(11):1060-7
Date
Nov-1992
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Cohort Studies
Diabetes Mellitus, Type 1 - epidemiology - genetics
Diabetes Mellitus, Type 2 - epidemiology - genetics
Diseases in Twins - epidemiology - genetics
Female
Finland - epidemiology
Humans
Male
Middle Aged
Population
Registries
Twins, Dizygotic
Twins, Monozygotic
Abstract
We studied the cumulative incidence, concordance rate and heritability for diabetes mellitus in a nationwide cohort of 13,888 Finnish twin pairs of the same sex. The twins were born before 1958 and both co-twins were alive in 1967. Data on diabetes were derived through computerized record linkage from death certificates, the National Hospital Discharge Register and the National Drug Register. Records were reviewed in order to assign a diagnostic category to the 738 diabetic patients identified. Of these patients 109 had Type 1 (insulin-dependent) diabetes, 505 Type 2 (non-insulin-dependent) diabetes, 46 gestational diabetes, 24 secondary diabetes, 38 impaired glucose tolerance and 16 remained unclassified. The cumulative incidence of diabetes was 1.4% in men and 1.3% in women aged 28-59 years and 9.3% and 7.0% in men and women aged 60 years and over, respectively. The cumulative incidence did not differ between monozygotic and dizygotic twins. The concordance rate for Type 1 diabetes was higher among monozygotic (23% probandwise and 13% pairwise) than dizygotic twins (5% probandwise and 3% pairwise). The probandwise and pairwise concordance rates for Type 2 diabetes were 34% and 20% among monozygotic twins and 16% and 9% in dizygotic twins, respectively. Heritability for Type 1 diabetes was greater than that for Type 2 where both genetic and environmental effects seemed to play a significant role.
Notes
Comment In: Diabetologia. 1993 May;36(5):471-28314454
PubMed ID
1473616 View in PubMed
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Social predictors of adult asthma: a co-twin case-control study.

https://arctichealth.org/en/permalink/ahliterature195980
Source
Thorax. 2001 Mar;56(3):234-6
Publication Type
Article
Date
Mar-2001
Author
E. Huovinen
J. Kaprio
L A Laitinen
M. Koskenvuo
Author Affiliation
Department of Public Health, University of Helsinki, Finland. elisa.huovinen@helsinki.fi
Source
Thorax. 2001 Mar;56(3):234-6
Date
Mar-2001
Language
English
Publication Type
Article
Keywords
Adult
Asthma - epidemiology
Case-Control Studies
Educational Status
Female
Finland - epidemiology
Humans
Life Style
Logistic Models
Male
Middle Aged
Risk factors
Social Environment
Abstract
Environmental factors are needed to explain the observed increase in the prevalence of asthma during recent decades, despite the existence of a recognised genetic component in asthma. A co-twin case-control study was undertaken to examine possible social risk factors for asthma.
Asthma diagnoses were based on register data of reimbursed asthma medication. During 17 years follow up of the Finnish twin cohort, 262 twin pairs discordant for incident asthma were identified. Conditional logistic regression for 1-1 matched data was used for risk calculation.
The atopic twin had an increased risk of asthma compared with the non-atopic co-twin (RR 2.91, 95% CI 1.81 to 4.68). The more educated twin had a decreased risk of asthma compared with his/her twin sibling with less education (RR 0.45, 95% CI 0.23 to 0.86), and the twin who participated in conditioning exercise had a decreased risk of asthma compared with the more sedentary co-twin (RR 0.55, 95% CI 0.34 to 0.88).
In addition to allergic diseases, educational level and physical activity are associated with adult onset asthma, which indicates a role for factors associated with life style.
Notes
Cites: Eur Respir J. 1999 Jan;13(1):2-410836314
Cites: Int J Epidemiol. 1993 Dec;22(6):976-828144310
Cites: BMJ. 1996 May 11;312(7040):1195-98634562
Cites: J Allergy Clin Immunol. 1998 Nov;102(5):722-69819287
Cites: Thorax. 1997 Jan;52(1):49-549039240
Cites: JAMA. 1998 Feb 11;279(6):440-49466636
Cites: Thorax. 1996 Mar;51(3):288-928779133
PubMed ID
11182018 View in PubMed
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Relative effect of genetic and environmental factors on body height: differences across birth cohorts among Finnish men and women.

https://arctichealth.org/en/permalink/ahliterature196076
Source
Am J Public Health. 2000 Apr;90(4):627-30
Publication Type
Article
Date
Apr-2000
Author
K. Silventoinen
J. Kaprio
E. Lahelma
M. Koskenvuo
Author Affiliation
Department of Public Health, University of Helsinki, Finland. karri.silventoinen@helsinki.fi
Source
Am J Public Health. 2000 Apr;90(4):627-30
Date
Apr-2000
Language
English
Publication Type
Article
Keywords
Adult
Aged
Body Height - genetics
Cohort Studies
Cross-Sectional Studies
Environment
Female
Finland
Humans
Male
Middle Aged
Phenotype
Questionnaires
Sex Characteristics
Twins, Dizygotic - genetics - statistics & numerical data
Twins, Monozygotic - genetics - statistics & numerical data
Abstract
This study examined the change in heritability of adult body height across birth cohorts in Finland.
In 1981, cross-sectional questionnaires were completed by 10,968 twin pairs born before 1958. The effect of genetic factors was estimated via genetic modeling.
Heritability increased from the cohort born before 1929 (0.76, 95% confidence interval [CI] = 0.65, 0.88 in men; 0.66, 95% CI = 0.55, 0.77 in women) to that born in 1947 through 1957 (0.81, 95% CI = 0.73, 0.87 in men; 0.82, 95% CI = 0.75, 0.89 in women).
Heritability of height increased across Finnish birth cohorts born in the first half of this century and leveled off after World War II. Environmental factors, compared with genetic factors, appear to be more important among women than men.
Notes
Cites: Acta Paediatr Scand Suppl. 1971;220:42-84334807
Cites: Int J Obes Relat Metab Disord. 1998 Oct;22(10):949-579806309
Cites: Am J Hum Genet. 1974 Mar;26(2):154-614856692
Cites: Hum Biol. 1976 May;48(2):379-97770304
Cites: Hum Hered. 1978;28(4):241-54566252
Cites: Ann Hum Genet. 1978 Jul;42(1):15-24686682
Cites: Prog Clin Biol Res. 1978;24 Pt B:179-84569306
Cites: Ann Hum Biol. 1983 May-Jun;10(3):247-566870189
Cites: Soc Biol. 1982 Spring-Summer;29(1-2):53-666764304
Cites: Soc Biol. 1984 Fall-Winter;31(3-4):243-786400148
Cites: JAMA. 1986 Jul 4;256(1):51-43712713
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Cites: Br Med J. 1973 Dec 8;4(5892):573-54758516
PubMed ID
10754982 View in PubMed
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Heritability of leptin levels and the shared genetic effects on body mass index and leptin in adult Finnish twins.

https://arctichealth.org/en/permalink/ahliterature195405
Source
Int J Obes Relat Metab Disord. 2001 Jan;25(1):132-7
Publication Type
Article
Date
Jan-2001
Author
J. Kaprio
J. Eriksson
M. Lehtovirta
M. Koskenvuo
J. Tuomilehto
Author Affiliation
University of Helsinki, Department of Public Health, The Finnish Twin Cohort Study, Helsinki, Finland. Jaakko.Kaprio@Helsinki.Fi
Source
Int J Obes Relat Metab Disord. 2001 Jan;25(1):132-7
Date
Jan-2001
Language
English
Publication Type
Article
Keywords
Aged
Body Height
Body mass index
Body Weight - genetics
Cohort Studies
Environment
Female
Finland
Humans
Leptin - blood - genetics
Male
Middle Aged
Models, Genetic
Obesity - blood - genetics
Sex Characteristics
Twins, Dizygotic - genetics
Twins, Monozygotic - genetics
Abstract
Leptin is involved in the regulation of body weight, but the relative role of genetic and environmental influences on inter-individual variation in leptin levels is unknown.
To investigate the genetic and environmental contributions to the association of body mass index (BMI) with serum leptin levels, 58 monozygotic (MZ, 27M, 31F), and 74 like-sexed dizygotic (DZ, 32M, 42F) Finnish twin pairs aged 50--76 y were studied.
Serum leptin levels, weight, height, hip and waist measurements.
Women had higher mean leptin levels (16.8+/-9.5 ng/ml), and more overall variability in leptin levels than men (6.4+/-3.5 ng/ml; P
PubMed ID
11244469 View in PubMed
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Health related psychosocial correlates of neuroticism: a study of adult male twins in Finland.

https://arctichealth.org/en/permalink/ahliterature241105
Source
Acta Genet Med Gemellol (Roma). 1984;33(2):307-20
Publication Type
Article
Date
1984
Author
M. Koskenvuo
H. Langinvainio
J. Kaprio
S. Sarna
Source
Acta Genet Med Gemellol (Roma). 1984;33(2):307-20
Date
1984
Language
English
Publication Type
Article
Keywords
Adult
Diseases in Twins
Female
Finland
Genetics, Behavioral
Humans
Male
Neurotic Disorders - etiology - genetics - psychology
Pregnancy
Social Environment
Twins - psychology
Twins, Dizygotic - psychology
Twins, Monozygotic - psychology
Abstract
Some health related psychosocial correlates of the Eysenck neuroticism scale were examined in a questionnaire study of 1501 monozygotic (MZ) and 3455 dizygotic (DZ) male twin pairs representing the adult male twin population in Finland. In analyses of the individuals, 34% of the variance in neuroticism was associated to: psychological variables (stress of daily activities, life satisfaction, quality of sleep, and extroversion - the explanatory rate of this variable set was 30%), psychotropic drugs (5%), alcohol use (4%), and smoking (2%). Neuroticism was also associated to social, life change, and medical variables. In pairwise analyses, the heritability estimate (h2) was 0.54 for pairs living together and 0.39 for pairs living apart. It seems that heritability estimates are confounded by the closer intrapair relationship between members of MZ than DZ pairs. In pairwise analyses, 23% of the intrapair difference of neuroticism in MZ pairs was associated to intrapair differences in the aforementioned variables. The following explanatory rates were found: psychological variables, 21%; psychotropic drugs, 2%; alcohol use, 2%; and smoking, 1%. Neuroticism of pairs discordant for background variables showed similar intrapair differences as between individuals in the following variables: service vs farming work, use of alcohol, use of antacids, hypertension, heavy physical work, quality of sleep, changes of workplace for negative reasons, smoking, and use of tranquillizers. It appears that in Finland environmental factors explain at least 61% of the variability in neuroticism, and that factors determining neuroticism are also associated to health related behavior such as smoking, use of alcohol and psychotropic drugs.
PubMed ID
6540964 View in PubMed
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Familial and socioregional environmental effects on abstinence from alcohol at age sixteen.

https://arctichealth.org/en/permalink/ahliterature202260
Source
J Stud Alcohol Suppl. 1999 Mar;13:63-74
Publication Type
Article
Date
Mar-1999
Author
R J Rose
J. Kaprio
T. Winter
M. Koskenvuo
R J Viken
Author Affiliation
Department of Psychology, Indiana University, Bloomington 47405-1301, USA.
Source
J Stud Alcohol Suppl. 1999 Mar;13:63-74
Date
Mar-1999
Language
English
Publication Type
Article
Keywords
Adolescent
Adolescent Behavior - ethnology - psychology
Alcohol Drinking - epidemiology - genetics - psychology
Cohort Studies
Female
Finland - epidemiology - ethnology
Humans
Male
Parent-Child Relations
Parents - psychology
Sibling Relations
Temperance - psychology
Abstract
This study identifies, in genetically informative data, familial and socioregional environmental influences on abstinence from alcohol at age 16.
Data are from FinnTwin 16, a population-based study of five consecutive birth cohorts of Finnish twins (N = 5,747 twin individuals), yielding 2,711 pairs of known zygosity. Measures of alcohol use, embedded into a health-habits questionnaire, were taken from earlier epidemiological research with nontwin Finnish adolescents. The questionnaire was administered sequentially to all twins as they reached age 16. Separate questionnaires, including measures of alcohol use and screening questions for alcohol problems, were received from 5,243 of the twins' parents.
Abstinence from alcohol to age 16 exhibits very significant familial aggregation, largely due to nongenetic influences. Abstinence rates are influenced by socioregional variation, sibling interaction effects and parental drinking patterns. Sibling and parental influences are greater in some regional environments than in others: the relative likelihood that a twin abstains, given that the co-twin does, or that both parents do, is shown to be modulated by socioregional variation.
Environmental contexts affect the likelihood of maintaining abstinence from alcohol to midadolescence, and socioregional variation modulates influences of siblings and parents. The results illustrate how genetically informative data can inform prevention research by identifying target variables for intervention efforts.
PubMed ID
10225489 View in PubMed
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Genetic and environmental determinants of use and abuse of alcohol: the Finnish Twin Cohort studies.

https://arctichealth.org/en/permalink/ahliterature227328
Source
Alcohol Alcohol Suppl. 1991;1:131-6
Publication Type
Article
Date
1991

Genetic susceptibility to multiple sclerosis. A co-twin study of a nationwide series.

https://arctichealth.org/en/permalink/ahliterature232372
Source
Arch Neurol. 1988 Oct;45(10):1108-11
Publication Type
Article
Date
Oct-1988
Author
E. Kinnunen
J. Juntunen
L. Ketonen
S. Koskimies
Y T Konttinen
T. Salmi
M. Koskenvuo
J. Kaprio
Author Affiliation
Clinical Neurosciences, Institute of Occupational Health, Helsinki, Finland.
Source
Arch Neurol. 1988 Oct;45(10):1108-11
Date
Oct-1988
Language
English
Publication Type
Article
Keywords
Adult
Cohort Studies
Disease Susceptibility
Diseases in Twins - epidemiology
Female
Finland
HLA-B Antigens - analysis
HLA-B7 Antigen
HLA-DR Antigens - analysis
HLA-DR2 Antigen
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis - diagnosis - genetics - physiopathology
Neurologic Examination
Twins, Dizygotic
Twins, Monozygotic
Abstract
The problems of differentiation between environmental and genetic influences on the development of multiple sclerosis are well known. Twin studies may provide valuable information on this question. However, most published twin series are selected and no through clinical twin studies based on epidemiologic series have been carried out. In this study, all available same-sex twin pairs with clinically definite multiple sclerosis derived from the Finnish Twin Cohort of 15815 pairs were studied by clinical evaluation, magnetic resonance imaging, and visual and auditory evoked responses. The mean length of follow-up of the pairs after the onset of symptoms of multiple sclerosis was 20 years. Two of the seven monozygotic pairs were concordant; one was definitely so, and in the other, the co-twin of the index case had, in addition to clinical findings, white matter changes suggestive of multiple sclerosis in magnetic resonance imaging and abnormal visual evoked responses. All six dizygotic pairs were discordant. The frequency of the HLA antigen DR2 in probands (69%) was significantly increased, but the distribution among the healthy subjects and patients showed nonsignificant differences. The results indicate a genetic influence on the susceptibility to multiple sclerosis, although still unknown genetic determinants are possible involved.
PubMed ID
3263109 View in PubMed
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Risk of cancer in Finnish children living close to power lines.

https://arctichealth.org/en/permalink/ahliterature220094
Source
BMJ. 1993 Oct 9;307(6909):895-9
Publication Type
Article
Date
Oct-9-1993
Author
P K Verkasalo
E. Pukkala
M Y Hongisto
J E Valjus
P J Järvinen
K V Heikkilä
M. Koskenvuo
Author Affiliation
Department of Public Health, University of Helsinki, Finland.
Source
BMJ. 1993 Oct 9;307(6909):895-9
Date
Oct-9-1993
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Child
Child, Preschool
Cohort Studies
Electromagnetic fields - adverse effects
Environmental Exposure
Female
Finland - epidemiology
Housing
Humans
Incidence
Infant
Infant, Newborn
Male
Neoplasms - epidemiology - etiology
Residence Characteristics
Risk factors
Abstract
To investigate the risk of cancer in children living close to overhead power lines with magnetic fields of > or = 0.01 microteslas (microT).
Cohort study.
The whole of Finland.
68,300 boys and 66,500 girls aged 0-19 years living during 1970-89 within 500 m of overhead power lines of 110-400 kV in magnetic fields calculated to be > or = 0.01 microT. Subjects were identified by record linkages of nationwide registers.
Numbers of observed cases in follow up for cancer and standardised incidence ratios for all cancers and particularly for nervous system tumours, leukaemia, and lymphoma.
In the whole cohort 140 cases of cancer were observed (145 expected; standardised incidence ratio 0.97, 95% confidence interval 0.81 to 1.1). No statistically significant increases in all cancers and in leukaemia and lymphoma were found in children at any exposure level. A statistically significant excess of nervous system tumours was found in boys (but not in girls) who were exposed to magnetic fields of > or = 0.20 microT or cumulative exposure of > or = 0.40 microT years.
Residentia magnetic fields of transmission power lines do not constitute a major public health problem regarding childhood cancer. The small numbers do not allow further conclusions about the risk of cancer in stronger magnetic fields.
Notes
Cites: Am J Epidemiol. 1988 Jul;128(1):21-383164167
Cites: BMJ. 1993 Oct 9;307(6909):891-58241850
Cites: Am J Epidemiol. 1979 Mar;109(3):273-84453167
Cites: Am J Epidemiol. 1980 Mar;111(3):292-67361752
Cites: Am J Epidemiol. 1980 Apr;111(4):461-27377191
Cites: Bioelectromagnetics. 1986;7(2):191-2073741493
Cites: Int Arch Occup Environ Health. 1990;62(4):289-932379958
Cites: Br J Cancer. 1990 Dec;62(6):1008-142257204
Cites: Am J Epidemiol. 1991 Nov 1;134(9):923-371843457
Comment In: BMJ. 1994 Apr 30;308(6937):1162-38031373
Comment In: BMJ. 1993 Oct 9;307(6909):884-58241847
PubMed ID
8241851 View in PubMed
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Role of environment in the development of chronic bronchitis.

https://arctichealth.org/en/permalink/ahliterature235908
Source
Eur J Respir Dis Suppl. 1987;152:57-63
Publication Type
Article
Date
1987
Author
K. Husman
M. Koskenvuo
J. Kaprio
E O Terho
I. Vohlonen
Author Affiliation
Kuopio Regional Institute of Occupational Health, Finland.
Source
Eur J Respir Dis Suppl. 1987;152:57-63
Date
1987
Language
English
Publication Type
Article
Keywords
Adult
Agricultural Workers' Diseases - epidemiology
Bronchitis - epidemiology
Cereals
Cross-Sectional Studies
Dust - adverse effects
Environmental Exposure
Female
Finland
Humans
Male
Middle Aged
Registries
Twins
Abstract
Based on data in the Finnish Twin Registry, which was obtained by postal questionnaire, the prevalence of chronic bronchitis among non-smoking farmers was 3.6% and among a corresponding group of non-farmers (reference subjects) 3.4%. The six-year incidences of chronic bronchitis for these 2 groups were 2.7% and 0.7%, respectively. The difference in incidence between these groups was significant (p less than 0.001). The fact that the incidence among farming subjects was three times the incidence among non-farming subjects indicates that chronic bronchitis is a work-related disease among farmers. This is analogous to previous findings that symptoms compatible with chronic bronchitis occur more often among grain elevator workers than among urban dwellers. The occurrence of chronic bronchitis among both farmers and grain elevator workers probably is associated with exposure to grain dusts.
PubMed ID
3499347 View in PubMed
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Cardiovascular reflexes in monozygotic twins discordant for exposure to organic solvents.

https://arctichealth.org/en/permalink/ahliterature235974
Source
Acta Genet Med Gemellol (Roma). 1987;36(4):503-7
Publication Type
Article
Date
1987
Author
E. Matikainen
J. Juntunen
M. Koskenvuo
M. Antti-Poika
J. Kaprio
Author Affiliation
Institute of Occupation Health, Helsinki, Finland.
Source
Acta Genet Med Gemellol (Roma). 1987;36(4):503-7
Date
1987
Language
English
Publication Type
Article
Keywords
Adult
Aged
Autonomic Nervous System - physiology
Blood pressure
Environmental Exposure
Female
Finland
Heart - physiology
Heart rate
Humans
Male
Middle Aged
Pulse
Solvents - adverse effects
Twins
Twins, Monozygotic
Valsalva Maneuver
Abstract
Eighteen pairs of monozygotic twins discordant for long-term occupational exposure to organic solvents were examined for disturbances of cardiovascular reflexes. All of the subjects were asymptomatic, and considered themselves healthy. No significant differences were observed between the exposed and the nonexposed twins. The finding suggests that occupational solvent exposure at these particular levels is unlikely to cause disturbances of the autonomic nervous function.
PubMed ID
3454512 View in PubMed
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Childhood farm environment and asthma and sensitization in young adulthood.

https://arctichealth.org/en/permalink/ahliterature187520
Source
Allergy. 2002 Dec;57(12):1130-5
Publication Type
Article
Date
Dec-2002
Author
M. Kilpeläinen
E O Terho
H. Helenius
M. Koskenvuo
Author Affiliation
Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Finland.
Source
Allergy. 2002 Dec;57(12):1130-5
Date
Dec-2002
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Animals
Animals, Domestic - immunology
Antibody Specificity - immunology
Asthma - etiology - physiopathology
Bronchial Hyperreactivity - immunology - physiopathology
Bronchial Provocation Tests
Bronchoconstrictor Agents - adverse effects - diagnostic use
Environmental Exposure - adverse effects
Female
Finland
Forced Expiratory Volume - drug effects - physiology
Humans
Immunization
Immunoglobulin E - blood - immunology
Male
Methacholine Chloride - adverse effects - diagnostic use
Questionnaires
Radioallergosorbent Test
Respiratory Function Tests
School Health Services
Severity of Illness Index
Skin Tests
Abstract
Farm environment in childhood may protect against sensitization, allergic rhinitis, and asthma.
Subjects were obtained from 10 667 Finnish first-year university students who responded to a questionnaire survey on IgE-mediated diseases. Two random samples were selected from 1631 respondents in Turku: subjects with asthma or wheezing, and subjects without asthmatic symptoms. A total of 296 subjects (72%) participated. Skin prick tests (SPT), measurements of IgE-antibodies, methacholine challenge, and bronchodilation tests were performed. Weighted occurrence of current asthma and sensitization among students from "childhood farm" and "childhood nonfarm" environments were analyzed.
Current asthma was found in 3.1% of subjects with childhood farm environment, and in 12.4% with nonfarm environment (odds ratio (OR) 0.22; 95% confidence interval (CI) 0.07-0.70). There were fewer positive SPT to birch (8.3 vs. 24.2%, OR 0.28, 95% CI 0.07-1.15) and timothy pollen (12.6 vs. 30.3%, OR 0.33, 95% CI 0.09-1.20) among subjects with childhood farm environment, but more sensitization to house-dust mite (22.0 vs. 4.9%, OR 5.43, 95% CI 1.60-18.46). Sensitization to cat (RAST class >/= 3) was less common in subjects with farm compared to nonfarm environments in childhood (1.5 vs. 13.1%; OR 0.10, 95% CI 0.02-0.47).
Farm environment in childhood protects against adult asthma and sensitization-especially to cat-the most important asthma related allergen. In contrast, sensitization to house-dust mite was more common in farming subjects.
PubMed ID
12464040 View in PubMed
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Consistency and change of body mass index and weight. A study on 5967 adult Finnish twin pairs.

https://arctichealth.org/en/permalink/ahliterature215253
Source
Int J Obes Relat Metab Disord. 1995 May;19(5):310-7
Publication Type
Article
Date
May-1995
Author
M. Korkeila
J. Kaprio
A. Rissanen
M. Koskenvuo
Author Affiliation
Department of Public Health, University of Helsinki, Finland.
Source
Int J Obes Relat Metab Disord. 1995 May;19(5):310-7
Date
May-1995
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Animals
Body mass index
Body Weight - genetics
Cohort Studies
Female
Finland
Follow-Up Studies
Humans
Longitudinal Studies
Male
Middle Aged
Questionnaires
Twins, Dizygotic
Twins, Monozygotic
Abstract
To study twin resemblance for weight change (delta wt) and to assess the consistency of body mass index (BMI) over 6 years.
6 year follow-up based on identical mailed questionnaires in 1975 (baseline) and in 1981 (follow-up).
5967 same-sexed non-pregnant Finnish twin pairs aged 18-54 in 1975 (1106 male and 862 female monozygotic (MZ) and 2430 male and 1569 female dizygotic (DZ) pairs).
Intra-pair correlations of delta wt and BMI, estimates of genetic and environmental components of variance of delta wt and BMI.
Unadjusted mean delta wt was +2.0 (s.d. = 4.6) kg among MZ and 2.1 (4.9) kg among DZ male individuals. Corresponding values among MZ and DZ female individuals were +1.5 (4.4) kg and +1.7 (4.4) kg, respectively. Age and initial BMI together explained 8.0% of the male and 2.3% of the female phenotypic variance of delta wt. The intraclass correlations for delta wt (adjusted for age and initial BMI) for all pairs were 0.29 and 0.07 for MZ and DZ men and 0.25 and 0.05 for MZ and DZ women, respectively. The BMI of the twins increased slightly during the follow-up compared to the baseline values (23.9 (2.7) for MZ and 24.1 for DZ men and 23.0 (3.3) for MZ and 23.2 (3.42) for DZ women). The intra-class correlations for BMI at baseline (0.69 for MZ and 0.34 for DZ men and 0.67 for MZ and 0.29 for DZ women) were almost identical with the correlations at follow-up (0.67 for MZ and 0.32 for DZ men and 0.69 for MZ and 0.29 for DZ women). The intra-class correlations for both BMI and delta wt were consistently higher among pairs living together than among pairs living apart at baseline and at follow-up in both zygosity groups (MZ and DZ). Among pairs living apart at baseline, the longitudinal model for BMI showed that the correlation between genetic effects at baseline and at follow-up was very high (> 0.9 in all age groups among both genders). The correlations for environmental effects ranged from 0.50 to 0.67 during the follow-up period.
Weight changes in adults over a 6-year period appear to be determined by environmental effects rather than genetic factors. However, the genetic component in BMI is considerable and stable over time. Shared environment is likely to contribute to the resemblance of both delta wt and BMI among adult twin pairs, especially among MZ pairs.
PubMed ID
7647822 View in PubMed
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Malignant skin cancers in the Finnish Twin Cohort: a population-based study, 1976-97.

https://arctichealth.org/en/permalink/ahliterature188734
Source
Br J Dermatol. 2002 Sep;147(3):509-12
Publication Type
Article
Date
Sep-2002
Author
T. Milán
P K Verkasalo
J. Kaprio
M. Koskenvuo
E. Pukkala
Author Affiliation
Department of Public Health, University of Turku, Lemminkäisenkatu 1, FIN-20520 Turku, Finland. tiimil@dlc.fi
Source
Br J Dermatol. 2002 Sep;147(3):509-12
Date
Sep-2002
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - epidemiology - etiology - genetics
Diseases in Twins - epidemiology - etiology - genetics
Female
Finland - epidemiology
Follow-Up Studies
Genetic Predisposition to Disease
Humans
Incidence
Male
Melanoma - epidemiology - etiology - genetics
Middle Aged
Prospective Studies
Registries
Skin Neoplasms - epidemiology - etiology - genetics
Twins, Dizygotic
Twins, Monozygotic
Abstract
Both hereditary and environmental factors are implicated in the aetiology of cutaneous neoplasms. Studies of twins make it possible to estimate the contribution of inherited genes to the development of disease.
To assess the importance of hereditary and environmental factors (including physical environment and lifestyles) in malignant melanoma and malignant nonmelanoma of the skin.
The Finnish Twin Cohort, comprising 25 882 adult like-sexed twins with established zygosity, was linked with the Finnish Cancer Registry to identify malignant skin cancers in a prospective follow-up from 1976 to 1997. Standardized incidence ratios were computed based on national rates.
Sixty twins were diagnosed with melanoma and 49 twins with nonmelanoma during the follow-up. The risks of these cancers did not differ from the risk in the population at large. There was only one pair where both twins had a malignant skin cancer (dizygotic male twins both with squamous cell carcinoma).
The near-total lack of concordance for skin cancer in twin pairs suggests that environmental and not hereditary effects are most important in the causation of malignant skin cancers in a white population with low levels of sun exposure.
PubMed ID
12207592 View in PubMed
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Migration and mortality: a 20 year follow up of Finnish twin pairs with migrant co-twins in Sweden.

https://arctichealth.org/en/permalink/ahliterature190512
Source
J Epidemiol Community Health. 2002 May;56(5):362-6
Publication Type
Article
Date
May-2002
Author
N. Hammar
J. Kaprio
U. Hagström
L. Alfredsson
M. Koskenvuo
T. Hammar
Author Affiliation
Division of Epidemiology, Institute of Environmental Medicine, Karolinska institutet, Stockholm, Sweden. niklas.hammar@imm.ki.se
Source
J Epidemiol Community Health. 2002 May;56(5):362-6
Date
May-2002
Language
English
Publication Type
Article
Keywords
Adult
Confidence Intervals
Female
Finland - epidemiology
Humans
Longitudinal Studies
Male
Middle Aged
Mortality
Sex Distribution
Sweden - epidemiology
Transients and Migrants - statistics & numerical data
Abstract
Finland has a higher mortality overall and for major causes of death than Sweden, primarily in men. The objective of this study was to analyse mortality in migrants from Finland to Sweden.
A longitudinal study based on the Finnish Twin Cohort Study. Information about migration from Finland to Sweden, duration of stay in Sweden for the migrants, and deaths 1976-1995 was obtained from national registers. Observed numbers of deaths in migrants were compared with expected numbers based on the age standardised mortality experience of the Finnish Twin Cohort. First deaths in migrants and non-migrants of migrant discordant pairs were compared controlling for genetic and early childhood factors.
Twin pairs of the Finnish Twin Cohort Study where at least one twin had migrated to Sweden (1542 twin pairs).
Among men, migrants from Finland to Sweden showed an overall similar mortality compared with all subjects of the Finnish Twin Cohort (SMR 1.1; 95% CI 0.9 to 1.4). Mortality from non-violent causes was increased for migrants with at most 20 years in Sweden (SMR 1.9; 95% CI 1.2 to 2.6) and decreased in those with a longer stay (SMR 0.7; 95% CI 0.4 to 0.9). Similar results were obtained concerning first deaths in twin pairs discordant for migration. Among women, migrants had an increased mortality overall (SMR 1.4; 95% CI 1.0 to 1.8), from cardiovascular disease (SMR 1.7; 95% CI 1.0 to 2.7), and from violent causes (SMR 2.5; 95% CI 1.2 to 4.6) compared with all women of the Finnish Twin Cohort. In analyses of migrant discordant pairs only first deaths from cardiovascular disease tended to be more common in the migrants than in non-migrant co-twins.
Migrants from Finland to Sweden seem to have an overall mortality comparable to that prevailing in Finland suggesting no strong influence on mortality by the migration. Duration of stay seems to be associated with mortality in the migrants, at least in men, with a lower mortality after several years in Sweden.
Notes
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Cites: Am J Epidemiol. 1978 Sep;108(3):181-91707486
PubMed ID
11964433 View in PubMed
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