Skip header and navigation

Refine By

46 records – page 1 of 3.

Quantity and diversity of environmental microbial exposure and development of asthma: a birth cohort study.

https://arctichealth.org/en/permalink/ahliterature264087
Source
Allergy. 2014 Aug;69(8):1092-101
Publication Type
Article
Date
Aug-2014
Author
A M Karvonen
A. Hyvärinen
H. Rintala
M. Korppi
M. Täubel
G. Doekes
U. Gehring
H. Renz
P I Pfefferle
J. Genuneit
L. Keski-Nisula
S. Remes
J. Lampi
E. von Mutius
J. Pekkanen
Source
Allergy. 2014 Aug;69(8):1092-101
Date
Aug-2014
Language
English
Publication Type
Article
Keywords
Allergens - immunology
Asthma - diagnosis - epidemiology - etiology
Child
Child, Preschool
Cohort Studies
Dust
Environmental Exposure
Environmental Microbiology
Finland - epidemiology
Follow-Up Studies
Humans
Incidence
Infant
Infant, Newborn
Odds Ratio
Population Surveillance
Questionnaires
Abstract
Early-life exposure to environmental microbial agents may be associated with the development of allergies. The aim of the study was to identify better ways to characterize microbial exposure as a predictor of respiratory symptoms and allergies.
A birth cohort of 410 children was followed up until 6 years of age. Bacterial endotoxin, 3-hydroxy fatty acids, N-acetyl-muramic acid, fungal extracellular polysaccharides (EPS) from Penicillium and Aspergillus spp., ß-D-glucan, ergosterol, and bacterial or fungal quantitative polymerase chain reactions (qPCRs) were analyzed from dust samples collected at 2 months of age. Asthma, wheezing, cough, and atopic dermatitis were assessed using repeated questionnaires. Specific IgEs were determined at the age of 1 and 6 years.
Only few associations were found between single microbial markers and the studied outcomes. In contrast, a score for the total quantity of microbial exposure, that is, sum of indicators for fungi (ergosterol), Gram-positive (muramic acid) bacteria, and Gram-negative (endotoxin) bacteria, was significantly (inverted-U shape) associated with asthma incidence (P 
Notes
Cites: J Allergy Clin Immunol. 2008 Jul;122(1):114-8, 118.e1-518602569
Cites: Pediatrics. 2009 Aug;124(2):e329-3819651571
Cites: Ann Allergy Asthma Immunol. 2010 Mar;104(3):269-7020377118
Cites: J Microbiol Methods. 2010 Jul;82(1):78-8420434494
Cites: Clin Exp Allergy. 2010 Jun;40(6):902-1020412140
Cites: N Engl J Med. 2011 Feb 24;364(8):701-921345099
Cites: J Asthma. 2011 Sep;48(7):685-9321732750
Cites: Clin Exp Allergy. 2012 Aug;42(8):1246-5622805472
Cites: Int Arch Allergy Immunol. 2012;159(2):194-20322678428
Cites: Immunol Rev. 2009 Jan;227(1):221-3319120487
Cites: Lancet. 2001 Mar 10;357(9258):752-611253969
Cites: J Allergy Clin Immunol. 2002 Mar;109(3):379-9211897980
Cites: Syst Appl Microbiol. 2004 Mar;27(2):198-21015046309
Cites: Environ Health Perspect. 2004 May;112(6):659-6515121507
Cites: J Allergy Clin Immunol. 2004 May;113(5):860-715131567
Cites: Clin Chem Lab Med. 2005;43(9):963-616176178
Cites: Clin Exp Allergy. 2005 Oct;35(10):1272-816238785
Cites: Allergy. 2006 Apr;61(4):407-1316512801
Cites: J Allergy Clin Immunol. 2006 May;117(5):1067-7316675334
Cites: J Environ Monit. 2006 Jul;8(7):745-916826287
Cites: Ann Agric Environ Med. 2006;13(2):361-517196015
Cites: Allergy. 2007 May;62(5):504-1317441791
Cites: Eur Respir J. 2007 Jun;29(6):1144-5317331967
Cites: Toxicology. 1997 Dec 26;124(2):105-149458000
Cites: Allergy. 2005 May;60(5):611-815813805
Cites: Proc Am Thorac Soc. 2007 Jul;4(3):212-617607001
Cites: Arch Environ Occup Health. 2006 Jul-Aug;61(4):149-5717867568
Cites: Nature. 2005 Sep 15;437(7057):376-8016056220
PubMed ID
24931137 View in PubMed
Less detail

Moisture damage and childhood asthma: a population-based incident case-control study.

https://arctichealth.org/en/permalink/ahliterature166519
Source
Eur Respir J. 2007 Mar;29(3):509-15
Publication Type
Article
Date
Mar-2007
Author
J. Pekkanen
A. Hyvärinen
U. Haverinen-Shaughnessy
M. Korppi
T. Putus
A. Nevalainen
Author Affiliation
Dept of Environmental Health, National Public Health Institute, P.O.Box 95, 70701 Kuopio, Finland. juha.pekkanen@ktl.fi
Source
Eur Respir J. 2007 Mar;29(3):509-15
Date
Mar-2007
Language
English
Publication Type
Article
Keywords
Air Pollution, Indoor - adverse effects
Asthma - epidemiology - etiology
Case-Control Studies
Child
Child, Preschool
Cross-Sectional Studies
Environmental Exposure - adverse effects
Finland
Fungi - growth & development
Housing
Humans
Humidity - adverse effects
Infant
Prospective Studies
Respiratory Hypersensitivity - epidemiology - etiology
Risk factors
Abstract
Most previous studies on the association between moisture damage and asthma have been cross-sectional and relied on self-reported exposure and health. The present authors studied the association by carrying out careful home inspections among new, clinically determined cases of asthma and controls. New cases of asthma aged 12-84 months (n = 121) were recruited prospectively and matched for year of birth, sex and living area with two randomly selected population controls (n = 241). Trained engineers visited all homes. Both cases and controls had lived >or=75% of their lifetime or the past 2 yrs in their current home. Risk of asthma increased with severity of moisture damage and presence of visible mould in the main living quarters but not in other areas of the house. Cases more often had damage in their bedroom. Associations were comparable for atopic and nonatopic asthma and for children aged >30 months or
PubMed ID
17107993 View in PubMed
Less detail

Gestational age and occurrence of atopy at age 31--a prospective birth cohort study in Finland.

https://arctichealth.org/en/permalink/ahliterature196036
Source
Clin Exp Allergy. 2001 Jan;31(1):95-102
Publication Type
Article
Date
Jan-2001
Author
J. Pekkanen
B. Xu
M R Järvelin
Author Affiliation
Unit of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland.
Source
Clin Exp Allergy. 2001 Jan;31(1):95-102
Date
Jan-2001
Language
English
Publication Type
Article
Keywords
Adult
Agriculture
Asthma - epidemiology
Birth weight
Cohort Studies
Female
Finland - epidemiology
Gestational Age
Humans
Hypersensitivity, Immediate - epidemiology
Infant, Newborn
Infant, Premature
Prevalence
Prospective Studies
Skin Tests
Abstract
It has been suggested that main risk factors for development of allergic diseases operate already during pregnancy and in early childhood.
To study the association between gestational age, birth weight, parity and parental farming with the risk of atopy and asthma in young adults.
In a prospective birth cohort study, 5192 subjects born in Northern Finland in 1966 were followed up at the age of 31. Skin prick tests were done to three of the most common allergens in Finland and to house dust mite. Data on doctor-diagnosed asthma was obtained from questionnaires. Perinatal data had already been collected during pregnancy.
The risk of atopy increased linearly with increasing length of pregnancy among babies born in the 35th weak of gestation or later. Gestational age equal to, or over 40 weeks compared with less than 36 weeks was associated with an increased risk of atopy (multivariate odds ratio 1.65, 95% CI 1.16, 2.34). The association was stronger among farmers' children (P for interaction 0.01). High parity and being a farmer's child (multivariate odds ratio 0.50, 95% CI 0.42-0.60) was associated with decreased risk of atopy. In contrast, no associations were observed for doctor-diagnosed asthma.
The results underline the importance of pregnancy and very early childhood in the development of atopy, and suggest that timing of the environmental exposure is of importance for the immune system. No association was observed for asthma, which may be due to the multifactorial origins of asthma.
PubMed ID
11167956 View in PubMed
Less detail

Prevalence of allergic rhinitis and atopic dermatitis among children in four regions of Finland.

https://arctichealth.org/en/permalink/ahliterature15717
Source
Allergy. 1998 Jul;53(7):682-9
Publication Type
Article
Date
Jul-1998
Author
S T Remes
M. Korppi
M. Kajosaari
A. Koivikko
L. Soininen
J. Pekkanen
Author Affiliation
Unit of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland.
Source
Allergy. 1998 Jul;53(7):682-9
Date
Jul-1998
Language
English
Publication Type
Article
Keywords
Adolescent
Dermatitis, Atopic - epidemiology
Female
Finland - epidemiology
Humans
Longitudinal Studies
Male
Prevalence
Rhinitis, Allergic, Seasonal - epidemiology
Smoking - adverse effects
Abstract
The primary aim of the study was to evaluate the prevalences of allergic rhinitis and atopic dermatitis and their regional differences among Finnish children. The secondary objective was to determine whether the responses to the questions used are affected by the pollen season if asked during such a season. In 1994-5, the self-reported prevalence of allergic symptoms in four regions of Finland was studied among 11,607 schoolchildren aged 13-14 years, as part of the International Study of Asthma and Allergies in Childhood (ISAAC). The prevalence of rhinoconjunctivitis during the preceding year was 16% in eastern Finland (Kuopio County, n=2821), 23% in southern Finland (Helsinki area, n=2771), 15% in southwestern Finland (Turku and Pori County, n=2983), and 16% in northern Finland (Lapland, n=3032). The respective prevalences of flexural dermatitis were 15%, 19%, 16%, and 18%. The surveys were performed in winter, except in the Helsinki area where the survey was carried out mainly in the spring pollen season. Among the children studied in autumn in Helsinki, the prevalence of rhinoconjunctivitis was 19% and that of flexural dermatitis 17%. In multivariate analysis, flexural dermatitis was slightly more common in Lapland than in all other areas. In contrast, no significant differences were found in rhinoconjunctivitis. The prevalences of both disorders were twice as high in girls as in boys. In conclusion, regional differences in the prevalence of allergic rhinitis and atopic dermatitis were small in our country, and the prevalence figures were rather similar to those reported from other European countries. Almost half of the children had suffered from at least one atopic disorder, and over one-third had had symptoms in the past year. A clear season-of-response effect was observed; the prevalence of rhinoconjunctivitis was 25% when studied during the pollen seasons in the Helsinki area.
PubMed ID
9700037 View in PubMed
Less detail

Prevalence of asthma symptoms in video and written questionnaires among children in four regions of Finland.

https://arctichealth.org/en/permalink/ahliterature15783
Source
Eur Respir J. 1997 Aug;10(8):1787-94
Publication Type
Article
Date
Aug-1997
Author
J. Pekkanen
S T Remes
T. Husman
M. Lindberg
M. Kajosaari
A. Koivikko
L. Soininen
Author Affiliation
Unit of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland.
Source
Eur Respir J. 1997 Aug;10(8):1787-94
Date
Aug-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Asthma - epidemiology - physiopathology
Demography
Female
Finland
Health Surveys
Humans
Hypersensitivity - epidemiology
Male
Multivariate Analysis
Pollen
Prevalence
Questionnaires
Respiratory Sounds
Seasons
Sex Distribution
Smoking
Television
Abstract
The aim of this study was to determine whether there are regional differences in the prevalence of childhood asthma in Finland. A secondary objective was to assess the concordance between a written and a video questionnaire on asthma symptoms. In 1994-1995, the self-reported prevalence of asthma symptoms in four regions of Finland was studied among 11,607 schoolchildren aged 13-14 yrs, as part of the International Study of Asthma and Allergies in Childhood (ISAAC). The ISAAC written and video (AVQ 3,0) questionnaires were administered in the school setting. The prevalences of any wheezing during the previous 12 months in the ISAAC video questionnaire were 10% in East Finland (Kuopio County, n=2,821), 12% in South Finland (Helsinki area, n=2,771), 12% in Southwest Finland (Turku and Pori County, n=2,983), and 11% in North Finland (Lapland, n=3,032). The prevalences in the ISAAC written questionnaire were 13, 20, 15, and 16%, respectively. The surveys were performed during winter, except in Helsinki where the survey was carried out mainly during the spring pollen season. During autumn, the prevalence in the written questionnaire in Helsinki was 16%. In multivariate analysis, boys had a lower prevalence than girls, and smokers a threefold higher prevalence than nonsmokers. In conclusion, the prevalence of childhood asthma is lower in Finland than in other European countries, and may be even lower in the eastern part of the country. In contrast to the results from some other European countries, prevalences were lower in the video than in the written questionnaire, which suggests that translating the word "wheezing" into other languages, including Finnish, may produce results that cannot be compared. The strong association of smoking with wheeze both in the video and written questionnaires should be considered in further analysis of the ISAAC study.
PubMed ID
9272920 View in PubMed
Less detail

Childhood asthma in four regions in Scandinavia: risk factors and avoidance effects.

https://arctichealth.org/en/permalink/ahliterature15791
Source
Int J Epidemiol. 1997 Jun;26(3):610-9
Publication Type
Article
Date
Jun-1997
Author
B. Forsberg
J. Pekkanen
J. Clench-Aas
M B Mårtensson
N. Stjernberg
A. Bartonova
K L Timonen
S. Skerfving
Author Affiliation
Department of Environmental Health, Umeå University, Sweden.
Source
Int J Epidemiol. 1997 Jun;26(3):610-9
Date
Jun-1997
Language
English
Publication Type
Article
Keywords
Air Pollution - statistics & numerical data
Air Pollution, Indoor - statistics & numerical data
Asthma - epidemiology
Child
Confidence Intervals
Cough - epidemiology
Cross-Sectional Studies
Environmental Exposure - statistics & numerical data
Family Health
Female
Humans
Logistic Models
Male
Odds Ratio
Prevalence
Questionnaires
Research Support, Non-U.S. Gov't
Residence Characteristics - statistics & numerical data
Retrospective Studies
Risk factors
Scandinavia - epidemiology
Sex Factors
Urban Health - statistics & numerical data
Abstract
BACKGROUND: The high and increasing prevalence of childhood asthma is a major public health issue. Various risk factors have been proposed in local studies with different designs. METHODS: We have made a questionnaire study of the prevalence of childhood asthma, potential risk factors and their relations in four regions in Scandinavia (Umeå and Malmö in Sweden, Kuopio in eastern Finland and Oslo, Norway). One urban and one less urbanized area were selected in each region, and a study group of 15962 children aged 6-12 years was recruited. RESULTS: The prevalence of symptoms suggestive of asthma varied considerably between different areas (dry cough 8-19%, asthma attacks 4-8%, physician-diagnosed asthma 4-9%), as did the potential risk factors. Urban residency was generally not a risk factor. However, dry cough was common in the most traffic polluted area. Exposure to some of the risk factors. such as smoking indoors and moisture stains or moulds at home during the first 2 years of life, resulted in an increased risk. However, current exposure was associated with odds ratios less than one. CONCLUSIONS: Our findings were probably due to a combination of early impact and later avoidance of these risk factors. The effects of some risk factors were found to differ significantly between regions. No overall pattern between air pollution and asthma was seen, but air pollution differed less than expected between the areas.
PubMed ID
9222787 View in PubMed
Less detail

Obstetric complications and asthma in childhood.

https://arctichealth.org/en/permalink/ahliterature196769
Source
J Asthma. 2000;37(7):589-94
Publication Type
Article
Date
2000
Author
B. Xu
J. Pekkanen
M R Järvelin
Author Affiliation
Unit of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland. b.xu@ic.ac.uk
Source
J Asthma. 2000;37(7):589-94
Date
2000
Language
English
Publication Type
Article
Keywords
Adult
Apgar score
Asthma - epidemiology - etiology
Child
Cohort Studies
Delivery, Obstetric - adverse effects - methods
Female
Finland - epidemiology
Humans
Male
Pregnancy
Prevalence
Prospective Studies
Risk factors
Abstract
Studies have shown that perinatal factors are associated with childhood asthma. The current analyses examined the association between obstetric complications and risk of asthma at the age of 7 years using a prospectively population-based birth cohort in northern Finland. Results indicated that obstetric complications were associated with a higher risk of asthma among children. Those children who were administered special procedures at birth, i.e., cesarean section, vacuum extraction, and other procedures, including use of forceps, manual auxiliary, and extraction breech, had an adjusted odds ratio (OR) for asthma of 1.38 (95% confidence interval [CI] 1.00-1.92), 1.32 (95% CI 0.80-2.19), and 2.14 (95% CI 1.06-4.33), respectively, as compared to children who were delivered normally. Children who had a lower Apgar score at the first and the fifth minute after birth also had a higher risk as compared to those who had an Apgar score of 9-10. The results encourage further evaluation of the association between obstetric complications and risk of asthma among children in other populations, and further exploration of possible mechanisms underlying the association.
PubMed ID
11059526 View in PubMed
Less detail

Urban air pollution, and asthma and COPD hospital emergency room visits.

https://arctichealth.org/en/permalink/ahliterature158866
Source
Thorax. 2008 Jul;63(7):635-41
Publication Type
Article
Date
Jul-2008
Author
J I Halonen
T. Lanki
T. Yli-Tuomi
M. Kulmala
P. Tiittanen
J. Pekkanen
Author Affiliation
National Public Health Institute (KTL), Environmental Epidemiology Unit, PO Box 95, FIN-70701 Kuopio, Finland. jaana.halonen@ktl.fi
Source
Thorax. 2008 Jul;63(7):635-41
Date
Jul-2008
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Air Pollution - adverse effects
Asthma - chemically induced
Emergency Service, Hospital - utilization
Finland
Humans
Middle Aged
Particulate Matter - toxicity
Patient Acceptance of Health Care - statistics & numerical data
Pulmonary Disease, Chronic Obstructive - chemically induced
Urban health
Vehicle Emissions - toxicity
Abstract
There is little previous information of the effects of size fractioned particulate air pollution and source specific fine particles (PM(2.5); or=65 years).
Three to 5 day lagged increases in asthma visits were found among children in association with nucleation (
Notes
Comment In: Thorax. 2008 Jul;63(7):574-618587030
PubMed ID
18267984 View in PubMed
Less detail

Short- and long-term association of serum cholesterol with mortality. The 25-year follow-up of the Finnish cohorts of the seven countries study.

https://arctichealth.org/en/permalink/ahliterature223654
Source
Am J Epidemiol. 1992 Jun 1;135(11):1251-8
Publication Type
Article
Date
Jun-1-1992
Author
J. Pekkanen
A. Nissinen
S. Punsar
M J Karvonen
Author Affiliation
Department of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland.
Source
Am J Epidemiol. 1992 Jun 1;135(11):1251-8
Date
Jun-1-1992
Language
English
Publication Type
Article
Keywords
Adult
Cerebrovascular Disorders - blood - mortality
Chi-Square Distribution
Cholesterol - blood
Cohort Studies
Coronary Disease - blood - mortality
Finland - epidemiology
Follow-Up Studies
Humans
Male
Middle Aged
Mortality
Neoplasms - blood - mortality
Proportional Hazards Models
Risk factors
Abstract
The association of serum cholesterol with cause-specific and all-cause mortality was assessed in a cohort of 1,426 men aged 40-59 years who were free of clinically evident heart disease at baseline (1959). A total of 748 deaths (53 percent of the participants) occurred during the 25-year follow-up period. Men with high serum cholesterol levels at baseline had high mortality due to coronary heart disease during both the early and later parts of the follow-up period. In contrast, the association of serum cholesterol with mortality due to causes other than coronary heart disease changed during follow-up (interaction of cholesterol with follow-up period: p = 0.004). During the first 10 years of follow-up, despite their high coronary mortality, men with high cholesterol levels had lower all-cause mortality (age-adjusted relative risk = 0.71 for serum cholesterol above 5.79 mmol/liter vs. below 5.80 mmol/liter; p = 0.03) because of their low cancer mortality (relative risk = 0.55, p = 0.03) and residual mortality (relative risk = 0.49, p less than 0.01). During the last 15 years of follow-up, cholesterol at baseline was no longer associated with mortality due to causes other than coronary heart disease, and consequently, because of their high coronary mortality, men with high cholesterol levels also had higher all-cause mortality (relative risk = 1.22, p = 0.05). The results suggest that to fully analyze the association of serum cholesterol with all-cause mortality, the follow-up period should be sufficiently long--possibly more than 10 years--and the possibility of a change in the direction of the association studied should always be considered.
PubMed ID
1626541 View in PubMed
Less detail

Does the predictive value of baseline coronary risk factors change over a 30-year follow-up?

https://arctichealth.org/en/permalink/ahliterature222201
Source
Cardiology. 1993;82(2-3):181-90
Publication Type
Article
Date
1993
Author
J. Pekkanen
M. Tervahauta
A. Nissinen
M J Karvonen
Author Affiliation
Department of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland.
Source
Cardiology. 1993;82(2-3):181-90
Date
1993
Language
English
Publication Type
Article
Keywords
Adult
Aged
Blood Pressure - physiology
Body mass index
Cause of Death
Cholesterol - blood
Cohort Studies
Coronary Disease - etiology - mortality
Finland - epidemiology
Follow-Up Studies
Humans
Male
Middle Aged
Risk factors
Rural Population - statistics & numerical data
Smoking - adverse effects
Survival Analysis
Survival Rate
Abstract
The association of baseline serum total cholesterol, systolic blood pressure, smoking and body mass index with coronary heart disease (CHD) mortality was analyzed among 1,619 men aged 40-59 at baseline. Analyses were made separately for the first, second and third decade of follow-up. Serum cholesterol and smoking more than 9 cigarettes daily were strong predictors of risk of CHD death (n = 450) occurring early and late during the 30-year follow-up. After 20 years of follow-up, systolic blood pressure was no longer associated with CHD risk. In contrast, highest tertile of body mass index (over 24.7 kg/m2) was only then associated with increased CHD risk. The correlations between the baseline and the 30-year risk factor values were 0.42 for serum cholesterol (n = 444), 0.28 for systolic blood pressure (n = 444) and 0.57 for body mass index (n = 429). Our results showed large differences in the long-term predictive power of the classical coronary risk factors. The reasons for these differences are discussed.
PubMed ID
8324779 View in PubMed
Less detail

Exposure to natural fluoride in well water and hip fracture: a cohort analysis in Finland.

https://arctichealth.org/en/permalink/ahliterature200558
Source
Am J Epidemiol. 1999 Oct 15;150(8):817-24
Publication Type
Article
Date
Oct-15-1999
Author
P. Kurttio
N. Gustavsson
T. Vartiainen
J. Pekkanen
Author Affiliation
National Public Health Institute, Unit of Environmental Epidemiology, Kuopio, Finland.
Source
Am J Epidemiol. 1999 Oct 15;150(8):817-24
Date
Oct-15-1999
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Cohort Studies
Environmental Exposure - adverse effects
Female
Finland - epidemiology
Fluorides - adverse effects - analysis
Hip Fractures - epidemiology - etiology
Humans
Incidence
Male
Middle Aged
Population Surveillance
Regression Analysis
Retrospective Studies
Risk factors
Rural Population
Water supply
Abstract
In the retrospective cohort study based on record linkage, the authors studied a cohort of persons born in 1900-1930 (n = 144,627), who had lived in the same rural location at least from 1967 to 1980. Estimates for fluoride concentrations (median, 0.1 mg/liter; maximum, 2.4 mg/liter) in well water in each member of the cohort were obtained by a weighted median smoothing method based on ground water measurements. Information on hip fractures was obtained from the Hospital Discharge Registry for 1981-1994. No association was observed between hip fractures and estimated fluoride concentration in the well water in either men or women when all age groups were analyzed together. However, the association was modified by age and sex so that among younger women, those aged 50-64 years, higher fluoride levels increased the risk of hip fractures. Among older men and women and younger men, no consistent association was seen. The adjusted rate ratio was 2.09 (95% confidence interval: 1.16, 3.76) for younger women who were the most exposed (>1.5 mg/liter) when compared with those who were the least exposed (
PubMed ID
10522652 View in PubMed
Less detail

Prenatal factors and occurrence of rhinitis and eczema among offspring.

https://arctichealth.org/en/permalink/ahliterature200863
Source
Allergy. 1999 Aug;54(8):829-36
Publication Type
Article
Date
Aug-1999
Author
B. Xu
M R Järvelin
J. Pekkanen
Author Affiliation
Unit of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland.
Source
Allergy. 1999 Aug;54(8):829-36
Date
Aug-1999
Language
English
Publication Type
Article
Keywords
Adult
Child
Cohort Studies
Contraception
Dermatitis, Atopic - epidemiology - etiology
Female
Finland - epidemiology
Humans
Parity
Pregnancy
Pregnancy Complications, Infectious
Prenatal Care
Prenatal Exposure Delayed Effects
Prevalence
Prospective Studies
Rhinitis, Allergic, Perennial - epidemiology - etiology
Rhinitis, Allergic, Seasonal - epidemiology - etiology
Risk factors
Socioeconomic Factors
Weight Gain
Abstract
It has recently been suggested that an atopic phenotype may already be programmed in utero. We examine here the association between prenatal factors and the subsequent development of allergic rhinitis and eczema among offspring.
The analyses were based on 8088 children in a population-based prospective birth cohort started in northern Finland in 1985-6.
The prevalences of allergic rhinitis and allergic eczema by the age of 7 years among 8088 children were 3.3% and 6.7%, respectively. The results indicate that low parity, febrile infections in pregnancy, and the use of contraceptives before pregnancy increased the risk of allergic disorders among children. Bleeding in the first trimester and a greater weight gain during pregnancy appeared to be risk factors for rhinitis only. Children whose mothers experienced infections in the first trimester had ORs of 2.65 (95% CI 1.50-4.69) for rhinitis and 1.63 (95% CI 1.00-2.69) for eczema after adjustment for potential confounders.
Obstetric complications and infection in pregnancy may increase the risk of allergic disorders among the offspring.
PubMed ID
10485386 View in PubMed
Less detail

Maternal infections in pregnancy and the development of asthma among offspring.

https://arctichealth.org/en/permalink/ahliterature200908
Source
Int J Epidemiol. 1999 Aug;28(4):723-7
Publication Type
Article
Date
Aug-1999
Author
B. Xu
J. Pekkanen
M R Järvelin
P. Olsen
A L Hartikainen
Author Affiliation
Unit of Environmental Epidemiology, National Public Health Institute, Kuopio, Finland. bxua@ktl.fi
Source
Int J Epidemiol. 1999 Aug;28(4):723-7
Date
Aug-1999
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age of Onset
Asthma - epidemiology - etiology
Child
Female
Finland - epidemiology
Follow-Up Studies
Humans
Incidence
Male
Maternal Age
Maternal Exposure - adverse effects
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Prevalence
Questionnaires
Retrospective Studies
Sex Factors
Vaginitis - complications - epidemiology
Abstract
Previous studies have suggested that asthma phenotype could probably be programmed before birth. The current study examined the impact of maternal vaginitis and febrile infections during pregnancy on the subsequent development of asthma among children.
The analyses were based on 8088 children from the northern Finland birth cohort, 1985-1986.
The prevalence of asthma at age 7 was 3.5%. Children had a higher risk of asthma if their mothers experienced vaginitis and febrile infections during pregnancy, odds ratio (OR) = 1.41, (95% CI: 1.08-1.84) and 1.65 (95% CI: 1.25-2.18), respectively, after adjusting for other covariates. There was a clear time trend in risk of childhood asthma corresponding to the timing of maternal febrile infections in pregnancy. The adjusted OR for the first, second and third trimesters were 2.08 (95% CI: 1.13-3.82), 1.73 (95% CI: 1.09-2.75) and 1.44 (95% CI: 0.97-2.15), respectively. Maternal history of allergic diseases, birthweight
PubMed ID
10480702 View in PubMed
Less detail

Arsenic concentrations in well water and risk of bladder and kidney cancer in Finland.

https://arctichealth.org/en/permalink/ahliterature201045
Source
Environ Health Perspect. 1999 Sep;107(9):705-10
Publication Type
Article
Date
Sep-1999
Author
P. Kurttio
E. Pukkala
H. Kahelin
A. Auvinen
J. Pekkanen
Author Affiliation
National Public Health Institute, Unit of Environmental Epidemiology, Kuopio, Finland. paivi.kurttio@ktl.fi
Source
Environ Health Perspect. 1999 Sep;107(9):705-10
Date
Sep-1999
Language
English
Publication Type
Article
Keywords
Arsenic - analysis
Arsenic Poisoning - complications
Female
Finland
Fresh Water - analysis
Humans
Kidney Neoplasms - chemically induced
Male
Risk
Smoking - adverse effects
Urinary Bladder Neoplasms - chemically induced
Water Pollutants, Chemical - toxicity
Water Supply - analysis
Abstract
We assessed the levels of arsenic in drilled wells in Finland and studied the association of arsenic exposure with the risk of bladder and kidney cancers. The study persons were selected from a register-based cohort of all Finns who had lived at an address outside the municipal drinking-water system during 1967-1980 (n = 144,627). The final study population consisted of 61 bladder cancer cases and 49 kidney cancer cases diagnosed between 1981 and 1995, as well as an age- and sex-balanced random sample of 275 subjects (reference cohort). Water samples were obtained from the wells used by the study population at least during 1967-1980. The total arsenic concentrations in the wells of the reference cohort were low (median = 0.1 microg/L; maximum = 64 microg/L), and 1% exceeded 10 microg/L. Arsenic exposure was estimated as arsenic concentration in the well, daily dose, and cumulative dose of arsenic. None of the exposure indicators was statistically significantly associated with the risk of kidney cancer. Bladder cancer tended to be associated with arsenic concentration and daily dose during the third to ninth years prior to the cancer diagnosis; the risk ratios for arsenic concentration categories 0.1-0.5 and [Greater/equal to] 0.5 microg/L relative to the category with
Notes
Cites: J Natl Cancer Inst. 1968 Mar;40(3):453-635644201
Cites: Mutat Res. 1997 Jun;386(3):263-779219564
Cites: Lancet. 1988 Feb 20;1(8582):414-52893213
Cites: Am J Epidemiol. 1989 Dec;130(6):1123-322589305
Cites: Ind Health. 1990;28(2):53-622376527
Cites: Cancer Res. 1990 Sep 1;50(17):5470-42386951
Cites: Biol Trace Elem Res. 1989 Jul-Sep;21:373-812484616
Cites: Epidemiology. 1992 May;3(3):223-311591321
Cites: Biol Trace Elem Res. 1992 Apr-Jun;33:51-621379460
Cites: Environ Health Perspect. 1992 Jul;97:259-671396465
Cites: Am J Epidemiol. 1992 Aug 15;136(4):417-211415161
Cites: Br J Cancer. 1992 Nov;66(5):888-921419632
Cites: Am J Epidemiol. 1992 Sep 15;136(6):712-211442737
Cites: Epidemiology. 1994 Mar;5(2):204-178172996
Cites: J Submicrosc Cytol Pathol. 1994 Apr;26(2):203-108019944
Cites: Int J Radiat Biol. 1994 Oct;66(4):367-727930838
Cites: Am J Epidemiol. 1995 Feb 1;141(3):198-2097840093
Cites: Cancer Res. 1995 Mar 15;55(6):1296-3007882325
Cites: Am J Epidemiol. 1995 Mar 15;141(6):523-307900719
Cites: Cancer. 1995 May 15;75(10):2552-77736400
Cites: Biometrics. 1994 Dec;50(4):1064-727786988
Cites: Cancer Lett. 1996 Jan 2;98(2):227-318556713
Cites: Epidemiology. 1997 Sep;8(5):545-509270957
Cites: Regul Toxicol Pharmacol. 1997 Oct;26(2):219-299356285
Cites: APMIS Suppl. 1997;76:9-479462818
Cites: Arch Environ Contam Toxicol. 1998 Apr;34(3):297-3059504979
Cites: Am J Epidemiol. 1998 Apr 1;147(7):660-99554605
Cites: J Environ Pathol Toxicol Oncol. 1998;17(3-4):205-169726792
Cites: Int J Epidemiol. 1998 Aug;27(4):561-99758107
Cites: Chem Biol Interact. 1996 Jan 5;99(1-3):147-648620564
Cites: Epidemiology. 1996 Mar;7(2):117-248834549
Cites: Cent Eur J Public Health. 1996 Dec;4(4):246-98997533
Cites: Environ Health Perspect. 1977 Aug;19:109-19908285
PubMed ID
10464069 View in PubMed
Less detail

Personally measured weekly exposure to NO2 and respiratory health among preschool children.

https://arctichealth.org/en/permalink/ahliterature201161
Source
Eur Respir J. 1999 Jun;13(6):1411-7
Publication Type
Article
Date
Jun-1999
Author
K. Mukala
J. Pekkanen
P. Tiittanen
S. Alm
R O Salonen
J. Tuomisto
Author Affiliation
Dept. of Environmental Medicine, National Public Health Institute, Kuopio, Finland.
Source
Eur Respir J. 1999 Jun;13(6):1411-7
Date
Jun-1999
Language
English
Publication Type
Article
Keywords
Child
Child, Preschool
Environmental Exposure
Female
Finland
Humans
Male
Nitrogen Dioxide - adverse effects
Oxidants, Photochemical - adverse effects
Peak Expiratory Flow Rate
Prospective Studies
Respiratory Tract Diseases - chemically induced - diagnosis
Seasons
Abstract
Nitrogen dioxide is known as a deep lung irritant. The aim of this study was to find out whether the relatively low ambient air NO2 concentrations in the northern city of Helsinki had an impact on the respiratory health of children. The association between personal exposure to ambient air NO2 and respiratory health was investigated in a 13-week follow-up study among 163 preschool children aged 3-6 yrs. Personal weekly average exposure to NO2 was measured by passive diffusion samplers attached to the outer garments. Symptoms were recorded daily in a diary by the parents. Among 53 children, peak expiratory flow (PEF) was measured at home in the mornings and evenings. The association between NO2 exposure and respiratory symptoms was examined with Poisson regression. The median personal NO2 exposure was 21.1 microg x m(-3) (range 4-99 microg x m(-3)). An increased risk of cough was associated with increasing NO2 exposure (risk ratio = 1.52; 95% confidence interval 1.00-2.31). There was no such association between personal weekly NO2 exposure and nasal symptoms, but a nonsignificant negative association was found between the exposure and the weekly average deviation in PEF. In conclusion, even low ambient air NO2 concentrations can increase the risk of respiratory symptoms among preschool children.
PubMed ID
10445621 View in PubMed
Less detail

Green areas around homes reduce atopic sensitization in children.

https://arctichealth.org/en/permalink/ahliterature266308
Source
Allergy. 2015 Feb;70(2):195-202
Publication Type
Article
Date
Feb-2015
Author
L. Ruokolainen
L. von Hertzen
N. Fyhrquist
T. Laatikainen
J. Lehtomäki
P. Auvinen
A M Karvonen
A. Hyvärinen
V. Tillmann
O. Niemelä
M. Knip
T. Haahtela
J. Pekkanen
I. Hanski
Source
Allergy. 2015 Feb;70(2):195-202
Date
Feb-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Agriculture
Allergens - immunology
Child
Child, Preschool
Environment
Environmental Exposure
Estonia - epidemiology
Female
Finland - epidemiology
Forests
Housing
Humans
Hypersensitivity, Immediate - epidemiology - etiology
Immunoglobulin E - blood - immunology
Infant
Male
Microbiota
Odds Ratio
Prevalence
Skin - immunology - microbiology
Young Adult
Abstract
Western lifestyle is associated with high prevalence of allergy, asthma and other chronic inflammatory disorders. To explain this association, we tested the 'biodiversity hypothesis', which posits that reduced contact of children with environmental biodiversity, including environmental microbiota in natural habitats, has adverse consequences on the assembly of human commensal microbiota and its contribution to immune tolerance.
We analysed four study cohorts from Finland and Estonia (n = 1044) comprising children and adolescents aged 0.5-20 years. The prevalence of atopic sensitization was assessed by measuring serum IgE specific to inhalant allergens. We calculated the proportion of five land-use types--forest, agricultural land, built areas, wetlands and water bodies--in the landscape around the homes using the CORINE2006 classification.
The cover of forest and agricultural land within 2-5 km from the home was inversely and significantly associated with atopic sensitization. This relationship was observed for children 6 years of age and older. Land-use pattern explained 20% of the variation in the relative abundance of Proteobacteria on the skin of healthy individuals, supporting the hypothesis of a strong environmental effect on the commensal microbiota.
The amount of green environment (forest and agricultural land) around homes was inversely associated with the risk of atopic sensitization in children. The results indicate that early-life exposure to green environments is especially important. The environmental effect may be mediated via the effect of environmental microbiota on the commensal microbiota influencing immunotolerance.
Notes
Cites: Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14691-620679230
Cites: Proc Natl Acad Sci U S A. 2012 May 22;109(21):8334-922566627
Cites: Nature. 2012 Sep 13;489(7415):231-4122972296
Cites: Br J Dermatol. 2013 Nov;169(5):983-9123782060
Cites: Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18360-724154724
Cites: Semin Immunol. 2013 Nov 30;25(5):378-8724209708
Cites: Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):805-1024344318
Cites: J Allergy Clin Immunol. 2014 Dec;134(6):1301-1309.e1125262465
Cites: Clin Exp Allergy. 2000 Sep;30(9):1230-410971468
Cites: Lancet. 2001 Oct 6;358(9288):1129-3311597666
Cites: Science. 2002 Apr 19;296(5567):490-411964470
Cites: JAMA. 2002 Aug 28;288(8):963-7212190366
Cites: BMJ. 1989 Nov 18;299(6710):1259-602513902
Cites: Clin Exp Allergy. 1999 May;29(5):611-710231320
Cites: Allergy. 2005 Nov;60(11):1357-6016197466
Cites: J Allergy Clin Immunol. 2006 Feb;117(2):334-4416461134
Cites: Int Arch Allergy Immunol. 2006;140(2):89-9516554659
Cites: Lancet. 2006 Aug 26;368(9537):733-4316935684
Cites: Nat Rev Immunol. 2006 Nov;6(11):869-7417063187
Cites: N Engl J Med. 2006 Nov 23;355(21):2226-3517124020
Cites: Environ Health Perspect. 2009 Jan;117(1):140-719165401
Cites: Sci Transl Med. 2009 Nov 11;1(6):6ra1420368178
Cites: Clin Exp Immunol. 2010 Apr;160(1):1-920415844
Cites: Clin Exp Immunol. 2010 Apr;160(1):70-920415854
Cites: Br J Dermatol. 2010 May;162(5):964-7320331459
Cites: FEMS Microbiol Lett. 2010 Jun;307(1):80-620412303
Cites: Nat Rev Immunol. 2010 Dec;10(12):861-821060319
Cites: EMBO Rep. 2011 Nov;12(11):1089-9321979814
PubMed ID
25388016 View in PubMed
Less detail

Vacuum-assisted delivery is associated with late-onset asthma.

https://arctichealth.org/en/permalink/ahliterature151385
Source
Allergy. 2009 Oct;64(10):1530-8
Publication Type
Article
Date
Oct-2009
Author
L. Keski-Nisula
M. Harju
M-R Järvelin
J. Pekkanen
Author Affiliation
Environmental Health Department, National Institute for Health and Welfare, Kuopio, Finland.
Source
Allergy. 2009 Oct;64(10):1530-8
Date
Oct-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Age of Onset
Allergens - diagnostic use - immunology
Asthma - diagnosis - epidemiology - etiology - immunology
Child
Cohort Studies
Delivery, Obstetric - adverse effects
Female
Finland - epidemiology
Humans
Hypersensitivity, Immediate - epidemiology - etiology - immunology
Pregnancy
Prevalence
Rhinitis, Allergic, Seasonal - epidemiology - etiology - immunology
Skin Tests
Vacuum Extraction, Obstetrical - adverse effects
Abstract
Perinatal factors during delivery might modulate fetal immunological development and thereby be associated with the development of allergic diseases and asthma later.
Perinatal data was recorded during pregnancy and at the time of delivery in regard to 5823 children who were born in Northern Finland in 1985-1986. Data from self-administered questionnaires were available at the ages of 7 and 15-16 years and skin prick tests for four main allergens were carried out at the age of 15-16 years. Only singletons delivered by the vaginal route were analyzed.
There was a higher prevalence of doctor-diagnosed asthma at any time of life among children who were delivered by vacuum extraction (RR 1.80, 95% CI 1.27-2.56; P
PubMed ID
19385949 View in PubMed
Less detail

Scientific rationale for the Finnish Allergy Programme 2008-2018: emphasis on prevention and endorsing tolerance.

https://arctichealth.org/en/permalink/ahliterature151405
Source
Allergy. 2009 May;64(5):678-701
Publication Type
Article
Date
May-2009
Author
L C von Hertzen
J. Savolainen
M. Hannuksela
T. Klaukka
A. Lauerma
M J Mäkelä
J. Pekkanen
A. Pietinalho
O. Vaarala
E. Valovirta
E. Vartiainen
T. Haahtela
Author Affiliation
Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland.
Source
Allergy. 2009 May;64(5):678-701
Date
May-2009
Language
English
Publication Type
Article
Keywords
Allergens - immunology
Clinical Trials as Topic
Cytokines - immunology - metabolism
Finland
Gastrointestinal Tract - immunology - metabolism
Humans
Hypersensitivity - economics - immunology - prevention & control
Immune Tolerance - immunology
Immunity, Innate
Immunity, Mucosal
Immunotherapy
National Health Programs - trends
Probiotics - therapeutic use
T-Lymphocyte Subsets - immunology - metabolism
T-Lymphocytes, Regulatory - immunology - metabolism
Toll-Like Receptors - immunology - metabolism
Abstract
In similarity to many other western countries, the burden of allergic diseases in Finland is high. Studies worldwide have shown that an environment rich in microbes in early life reduces the subsequent risk of developing allergic diseases. Along with urbanization, such exposure has dramatically reduced, both in terms of diversity and quantity. Continuous stimulation of the immune system by environmental saprophytes via the skin, respiratory tract and gut appears to be necessary for activation of the regulatory network including regulatory T-cells and dendritic cells. Substantial evidence now shows that the balance between allergy and tolerance is dependent on regulatory T-cells. Tolerance induced by allergen-specific regulatory T-cells appears to be the normal immunological response to allergens in non atopic healthy individuals. Healthy subjects have an intact functional allergen-specific regulatory T-cell response, which in allergic subjects is impaired. Evidence on this exists with respect to atopic dermatitis, contact dermatitis, allergic rhinitis and asthma. Restoration of impaired allergen-specific regulatory T-cell response and tolerance induction has furthermore been demonstrated during allergen-specific subcutaneous and sublingual immunotherapy and is crucial for good therapeutic outcome. However, tolerance can also be strengthened unspecifically by simple means, e.g. by consuming farm milk and spending time in nature. Results so far obtained from animal models indicate that it is possible to restore tolerance by administering the allergen in certain circumstances both locally and systemically. It has become increasingly clear that continuous exposure to microbial antigens as well as allergens in foodstuffs and the environment is decisive, and excessive antigen avoidance can be harmful and weaken or even prevent the development of regulatory mechanisms. Success in the Finnish Asthma Programme was an encouraging example of how it is possible to reduce both the costs and morbidity of asthma. The time, in the wake of the Asthma Programme, is now opportune for a national allergy programme, particularly as in the past few years, fundamentally more essential data on tolerance and its mechanisms have been published. In this review, the scientific rationale for the Finnish Allergy Programme 2008-2018 is outlined. The focus is on tolerance and how to endorse tolerance at the population level.
PubMed ID
19383025 View in PubMed
Less detail

Comparison of two-level and three-level classifications of moisture-damaged dwellings in relation to health effects.

https://arctichealth.org/en/permalink/ahliterature193503
Source
Indoor Air. 2001 Sep;11(3):192-9
Publication Type
Article
Date
Sep-2001
Author
U. Haverinen
T. Husman
M. Vahteristo
O. Koskinen
D. Moschandreas
A. Nevalainen
J. Pekkanen
Author Affiliation
National Public Health Institute, Laboratory of Environmental Microbiology and Unit of Environmental Epidemiology, POB 95, FIN-70701 Kuopio, Finland. ulla.haverinen@ktl.fi
Source
Indoor Air. 2001 Sep;11(3):192-9
Date
Sep-2001
Language
English
Publication Type
Article
Keywords
Adult
Air Pollution, Indoor - analysis
Dose-Response Relationship, Drug
Female
Finland
Humans
Humidity - adverse effects
Male
Public Health
Respiratory Tract Diseases - etiology
Risk assessment
Time Factors
Abstract
A total of 630 randomly selected dwellings were surveyed for visible signs of moisture damage by civil engineers, and questionnaire responses were collected from the occupants (a total of 1,017 adults) to analyse the association between moisture damage and occupant health. A three-level grading system was developed, which took into account the number of damage sites in buildings and estimated the severity of the damage. In the present study, this grading system was tested as an improved model of moisture damage-related exposure in comparison to a conventional two-category system: based on independent, technical criteria it also allowed dose-response to be estimated. The questionnaire probed 28 individual health symptoms, based on earlier reported associations with building moisture and mould-related exposure. Criteria in evaluating the goodness of the selected exposure model were (1) dose-responsiveness and (2) higher risk compared to a two-level classification. Dose-responsiveness was observed with the three-level classification in 7, higher risk in 10, and both criteria in 5 out of 28 health symptoms. Two-level classification had higher risk in 4 health symptoms. Dose-dependent risk increases for respiratory infections and lower respiratory symptoms, and recurrent irritative and skin symptoms were observed with the three-level classification using symptom score variables. Although the results did not unambiguously support the three-level model, they underline the importance of developing more accurate exposure models in assessing the severity of moisture damage.
PubMed ID
11521504 View in PubMed
Less detail

Children's homes--determinants of moisture damage and asthma in Finnish residences.

https://arctichealth.org/en/permalink/ahliterature169352
Source
Indoor Air. 2006 Jun;16(3):248-55
Publication Type
Article
Date
Jun-2006
Author
U. Haverinen-Shaughnessy
J. Pekkanen
A. Hyvärinen
A. Nevalainen
T. Putus
M. Korppi
D. Moschandreas
Author Affiliation
National Public Health Institute, Department of Environmental Health, Kuopio, Finland. haverinen@fulbrightweb.org
Source
Indoor Air. 2006 Jun;16(3):248-55
Date
Jun-2006
Language
English
Publication Type
Article
Keywords
Air Pollution, Indoor - adverse effects
Asthma - etiology - pathology
Child
Child Welfare
Child, Preschool
Family Health
Finland
Housing
Humans
Infant
Logistic Models
Ventilation
Water
Abstract
Certain housing characteristics increase the risk for moisture damage, which has been associated with increased risk for asthma in children. Modeling moisture damage as a function of these characteristics could therefore provide a simple tool to estimate building-related risk for asthma. This study aimed to find out specific associations between asthma case-control status of children and moisture damage and housing characteristics. The data consisted of information on 121 asthmatic children and predominately two age-, gender- and place of residence-matched control children for every case, and information on moisture damage and housing characteristics in the homes of the children. In a previous study, we found a statistically significant association between moisture damage observations in main living areas and asthma in children. Using logistic regression, five models were formulated to predict moisture damage status of the homes and moisture damage status of living areas. The models were able to classify the damage status correctly in 65.0-87.7% of the homes (kappa values 0.10-0.47) as functions of housing characteristics. None of the models qualified as a significant determinant of the case-control status of the children.
It can be hypothesized that building-related risk for asthma could be roughly estimated using models predicting moisture damage status of buildings as a function of easily obtainable housing characteristics. The results of this study indicated that, with a moderate certainty, it is possible to model moisture damage status of buildings using housing characteristics. However, the models developed did not associate with asthma in children. In conclusion, it was not possible to estimate the risk for asthma by studying housing characteristics only, but detailed information on moisture damage (e.g. location of damage) was crucial for such estimation.
PubMed ID
16683943 View in PubMed
Less detail

46 records – page 1 of 3.