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Blood serum concentrations of perfluorinated compounds in men from Greenlandic Inuit and European populations.

https://arctichealth.org/en/permalink/ahliterature302403
Source
Chemosphere. 2012 Sep;88(11):1269-75. doi: 10.1016/j.chemosphere.2012.03.049. Epub 2012 Apr 10.
Publication Type
Article
Date
2012
Author
Lindh CH
Rylander L
Toft G
Axmon A
Rignell-Hydbom A
Giwercman A
Pedersen HS
Góalczyk K
Ludwicki JK
Zvyezday V
Vermeulen R
Lenters V
Heederik D
Bonde JP
Jönsson BA
Source
Chemosphere. 2012 Sep;88(11):1269-75. doi: 10.1016/j.chemosphere.2012.03.049. Epub 2012 Apr 10.
Date
2012
Language
English
Geographic Location
Greenland
Publication Type
Article
Keywords
Adult
Alkanesulfonic Acids/blood
Caprylates/blood
European Continental Ancestry Group
Fluorocarbons/blood
Greenland
Humans
Inuits
Male
Seafood
Tandem Mass Spectrometry
Abstract
Perfluorinated compounds (PFCs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), are used in large quantities. They are persistent and found in measurable levels in human serum around the world. They have been associated with developmental, hepatic, and carcinogenic effects in animal studies. The aim of the present study was to describe levels of PFCs in serum among Inuits from Greenland and inhabitants from Warsaw, Poland and Kharkiv, Ukraine. Furthermore, the aim was to define social- and lifestyle related determinants of exposure for these compounds. Serum levels of seven PFCs were analyzed by liquid chromatography/tandem mass spectrometry (LC/MS/MS). The concentrations of PFOS and PFOA were the highest of all PFCs in all three populations with a total amount of almost 90% of the PFCs. The mean levels of PFOS and PFOA were in the Greenlandic Inuits 52 and 4.8 ng mL(-1), in Poland 19 and 5.2 ng mL(-1), and in Ukraine 8.1 and 1.9 ng mL(-1), respectively. Thus, levels of PFCs in the serum of Inuits on Greenland were among the highest described in a general population whereas the levels in Poland were similar to other industrialized countries. The exposure in Ukraine was rather low. In the Greenlandic Inuit population, intake of seafood, tea, age and area of living were significant determinants of PFOS concentrations and explained about 22% of the variation. For the other populations no strong determinants were found.
PubMed ID
22494529 View in PubMed
Less detail

Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances.

https://arctichealth.org/en/permalink/ahliterature302402
Source
Environ Health Perspect. 2015 Aug;123(8):841-6. doi: 10.1289/ehp.1408881. Epub 2015 Mar 26.
Publication Type
Article
Date
2015
Author
Høyer BB
Ramlau-Hansen CH
Vrijheid M
Valvi D
Pedersen HS
Zviezdai V
Jönsson BA
Lindh CH
Bonde JP
Toft G
Source
Environ Health Perspect. 2015 Aug;123(8):841-6. doi: 10.1289/ehp.1408881. Epub 2015 Mar 26.
Date
2015
Language
English
Geographic Location
Greenland
Russia
Publication Type
Article
Keywords
Alkanesulfonic Acids/toxicity
Anthropometry
Caprylates/toxicity
Child
Child, Preschool
Environmental Exposure
Environmental Pollutants/toxicity
Female
Fluorocarbons/toxicity
Greenland/epidemiology
Humans
Male
Pregnancy
Prenatal Exposure
Delayed Effects/chemically induced
Prenatal Exposure Delayed Effects/epidemiology
Ukraine/epidemiology
Abstract
BACKGROUND: In some animal studies, perfluorinated alkyl substances are suggested to induce weight gain. Human epidemiological studies investigating these associations are sparse.
OBJECTIVE: We examined pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and the prevalence of offspring overweight (> 1 SD) and waist-to-height ratio (WHtR) > 0.5 at 5-9 years of age.
METHODS: Sera from 1,022 pregnant women enrolled in the INUENDO cohort (2002-2004) from Greenland and Kharkiv (Ukraine) were analyzed for PFOA and PFOS using liquid chromatography-tandem mass spectrometry. Relative risks (RR) of being overweight and having WHtR > 0.5 in relation to continuous and categorized (tertiles) PFOA and PFOS were calculated at follow-up (2010-2012) using generalized linear models.
RESULTS: Pooled PFOA median (range) was 1.3 (0.2-5.1) and PFOS median (range) was 10.8 (0.8-73.0) ng/mL. For each natural logarithm-unit (ln-unit) increase of pregnancy PFOA, the adjusted RR of offspring overweight was 1.11 [95% confidence interval (CI): 0.82, 1.53] in Greenlandic children. In Ukrainian children, the adjusted RR of offspring overweight was 1.02 (95% CI: 0.72, 1.44) for each ln-unit increase of pregnancy PFOA. Prenatal exposure to PFOS was not associated with overweight in country-specific or pooled analysis. The adjusted RR of having WHtR > 0.5 for each ln-unit increase of prenatal exposure to PFOA was 1.30 (95% CI: 0.97, 1.74) in the pooled analysis. For 1-ln-unit increase of prenatal exposure to PFOS, the adjusted RR of having a WHtR > 0.5 was 1.38 (95% CI: 1.05, 1.82) in the pooled analysis.
CONCLUSIONS: The results indicate that prenatal PFOA and PFOS exposures may be associated with child waist-to-height ratio > 0.5. Prenatal PFOA and PFOS exposures were not associated with overweight.
PubMed ID
25809098 View in PubMed
Less detail

Exposure to perfluorinated compounds and human semen quality in Arctic and European populations.

https://arctichealth.org/en/permalink/ahliterature302401
Source
Hum Reprod. 2012 Aug;27(8):2532-40. doi: 10.1093/humrep/des185. Epub 2012 May 30.
Publication Type
Article
Date
2012
Author
Toft G
Jönsson BA
Lindh CH
Giwercman A
Spano M
Heederik D
Lenters V
Vermeulen R
Rylander L
Pedersen HS
Ludwicki JK
Zviezdai V
Bonde JP
Source
Hum Reprod. 2012 Aug;27(8):2532-40. doi: 10.1093/humrep/des185. Epub 2012 May 30.
Date
2012
Language
English
Geographic Location
Greenland
Russia
Publication Type
Article
Keywords
Adult Fluorocarbons/toxicity* Greenland Humans Male Mass Spectrometry/methods Poland Pregnancy Semen/drug effects* Semen Analysis* Sperm Count Sulfonic Acids/toxicity* Ukraine
Alkanesulfonic
Acids/toxicity
Arctic Regions
Caprylates/toxicity
Chromatography, Liquid/methods
Environmental Pollutants/toxicity
Europe
Female
Abstract
BACKGROUND: Perfluorinated compounds (PFCs) have been suspected to adversely affect human reproductive health. The aim of this study was to investigate the associations between PFC exposure and male semen quality.
METHODS: PFCs were measured in serum from 588 partners of pregnant women from Greenland, Poland and Ukraine who provided a semen sample, using liquid chromatography tandem mass spectrometry. Perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) could be detected in >97% of the samples. The associations between levels of these compounds and semen volume, sperm concentration, total sperm count, motility and morphology were assessed.
RESULTS: Across countries, sperm concentration, total sperm count and semen volume were not consistently associated with PFOS, PFOA, PFHxS or PFNA levels. The proportion of morphologically normal cells was 35% lower [95% confidence interval (CI): 4-66%) for the third tertile of PFOS exposure as compared with the first. A similar reduction was found in relation to increasing PFHxS levels. At the third PFOA exposure tertile, the percentage of motile spermatozoa was 19% (95% CI: 1 to 39%) higher than in the first.
CONCLUSIONS: The most robust finding in the present study was the negative associations between PFOS exposure and sperm morphology suggesting adverse effects of PFOS on semen quality, possibly due to interference with the endocrine activity or sperm membrane function. It cannot be excluded that this association and the positive association between PFOA and semen motility, which was not consistent across countries, might represent a chance finding due to the multiple statistical tests being performed.
PubMed ID
22647447 View in PubMed
Less detail

Cadmium may impair prostate function as measured by prostate specific antigen in semen: A cross-sectional study among European and Inuit men.

https://arctichealth.org/en/permalink/ahliterature302405
Source
Reprod Toxicol. 2015 Jun;53:33-8. doi: 10.1016/j.reprotox.2015.01.010. Epub 2015 Feb 3.
Publication Type
Article
Date
2015

Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study.

https://arctichealth.org/en/permalink/ahliterature302404
Source
Int J Obes (Lond). 2014 Jul;38(7):919-25. doi: 10.1038/ijo.2014.58. Epub 2014 Apr 10.
Publication Type
Article
Date
2014
Author
Høyer BB
Ramlau-Hansen CH
Henriksen TB
Pedersen HS
Góralczyk K
Zviezdai V
Jönsson BA
Heederik D
Lenters V
Vermeulen R
Bonde JP
Toft G
Source
Int J Obes (Lond). 2014 Jul;38(7):919-25. doi: 10.1038/ijo.2014.58. Epub 2014 Apr 10.
Date
2014
Language
English
Geographic Location
Greenland
Russia
Publication Type
Article
Keywords
Adult
Body mass index
Child
Child, Preschool
DDT/adverse effects
Environmental Exposure/adverse effects
Environmental Pollutants/adverse effects
European Continental Ancestry Group
Female
Follow-Up Studies
Greenland/epidemiology
Humans
Hydrocarbons, Chlorinated/adverse effects
Male
Mothers
Poland/epidemiology
Polychlorinated Biphenyls/adverse effects
Pregnancy
Prenatal Exposure Delayed Effects
Prospective Studies
Ukraine/epidemiology
Abstract
OBJECTIVE: To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) and body mass index (BMI) z-scores in 5- to 9-year-old children.
METHODS: Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N=1109) from Greenland, Warsaw (Poland), and Kharkiv (Ukraine) were analysed for CB-153 and p,p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age- and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis.
RESULTS: No clear associations between pregnancy CB-153 and p,p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10)??kg?m(-2), respectively). For postnatal CB-153 and p,p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27)?kg?m(-2), respectively.
CONCLUSIONS: This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p,p'-DDE and CB-153 and BMI at the age of 5-9 years.
PubMed ID
24718355 View in PubMed
Less detail

[Health care for North Sea naval personnel].

https://arctichealth.org/en/permalink/ahliterature302393
Source
Voen Med Zh. 1969 Jul;7:3-5.
Publication Type
Article
Date
1969
Author
Kozlov VF
Volchek BM
Source
Voen Med Zh. 1969 Jul;7:3-5.
Date
1969
Language
Russian
Geographic Location
Russia
Publication Type
Article
Keywords
Arctic Regions
Naval Medicine
USSR
PubMed ID
5343673 View in PubMed
Less detail

[Public health organization in the IAmalo-Nenetsk. national region].

https://arctichealth.org/en/permalink/ahliterature302392
Source
Sov Zdravookhr. 1950 Nov-Dec;6:20-5.
Publication Type
Article
Date
1950
Author
Moskovkin PT
Source
Sov Zdravookhr. 1950 Nov-Dec;6:20-5.
Date
1950
Language
Russian
Geographic Location
Russia
Publication Type
Article
Keywords
Humans
Organizations
Public Health
Siberia
PubMed ID
14787721 View in PubMed
Less detail

[Work experience of the Medical Council of the Iamalo-Nenets District Department of Public Health].

https://arctichealth.org/en/permalink/ahliterature302391
Source
Zdravookhr Ross Fed. 1969 Oct;13(10):15-7.
Publication Type
Article
Date
1969
Author
Moskovkin PT
Source
Zdravookhr Ross Fed. 1969 Oct;13(10):15-7.
Date
1969
Language
Russian
Geographic Location
Russia
Publication Type
Article
Keywords
Public Health Administration
Siberia
PubMed ID
5201523 View in PubMed
Less detail

[Lenin's national politics and organization of medical service for the peoples of the Far North].

https://arctichealth.org/en/permalink/ahliterature302390
Source
Zdravookhr Ross Fed. 1973 Jan;17(1):3-7.
Publication Type
Article
Date
1973

[Preparation of medical specialists from the indigenous population of the far north in medical institutes of the RSFSR].

https://arctichealth.org/en/permalink/ahliterature302389
Source
Zdravookhr Ross Fed. 1971 May;15(5):10-5.
Publication Type
Article
Date
1971
Author
Chikin SI
Cheknev BM
Source
Zdravookhr Ross Fed. 1971 May;15(5):10-5.
Date
1971
Language
Russian
Geographic Location
Russia
Publication Type
Article
Keywords
Cold Climate
Minority Groups/education
Education, Medical
Schools, Medical
Siberia
State Medicine
Students, Medical
PubMed ID
5211548 View in PubMed
Less detail

[Training of physicians from the Native population of the Arctic Region].

https://arctichealth.org/en/permalink/ahliterature302388
Source
Sov Zdravookhr. 1964;23:56-9.
Publication Type
Article
Date
1964
Author
Chikin SIa
Cheknev BM
Source
Sov Zdravookhr. 1964;23:56-9.
Date
1964
Language
Russian
Geographic Location
Russia
Publication Type
Article
Keywords
Arctic Regions
Cold Climate
Education, Medical
Education, Medical, Graduate
Humans
Physicians
USSR
PubMed ID
14185341 View in PubMed
Less detail

[Health service of the Soviet Union for the population of the Arctic Regions].

https://arctichealth.org/en/permalink/ahliterature302387
Source
Sov Med. 1965 Jan;28:137-41.
Publication Type
Article
Date
1965
Author
Chikin SIa
Cheknev BM
Source
Sov Med. 1965 Jan;28:137-41.
Date
1965
Language
Russian
Geographic Location
Russia
Publication Type
Article
Keywords
Arctic Regions
Cold Climate
Health services
Humans
Public Health Administration
USSR
PubMed ID
14312189 View in PubMed
Less detail

[The importance of cold and moisture in the development of obliterating diseases of vessels of the extremities].

https://arctichealth.org/en/permalink/ahliterature302386
Source
Sov Med. 1965 Nov;28(11):91-5.
Publication Type
Article
Date
1965

[Neurovascular diseases of the extremities caused by cold and moisture in workers of several northern regions].

https://arctichealth.org/en/permalink/ahliterature302385
Source
Klin Med (Mosk). 1970 Sep;48(9):128-31.
Publication Type
Article
Date
1970

[Neurovascular diseases of the extremities in workers in "water" shops of timber factories in the north].

https://arctichealth.org/en/permalink/ahliterature302384
Source
Gig Tr Prof Zabol. 1963 Jul;7:9-13.
Publication Type
Article
Date
1963

[From the history of medicine and public health of Archangel].

https://arctichealth.org/en/permalink/ahliterature302383
Source
Sov Zdravookhr. 1965;24(8):63-6.
Publication Type
Article
Date
1965

[40-year experiment in organization and improvement of teaching at the Archangel Medical Institute].

https://arctichealth.org/en/permalink/ahliterature302381
Source
Zdravookhr Ross Fed. 1974 Sep;0(9):26-9.
Publication Type
Article
Date
1974
Author
Tiukina, AP
Source
Zdravookhr Ross Fed. 1974 Sep;0(9):26-9.
Date
1974
Language
Russian
Geographic Location
Russia
Publication Type
Article
Keywords
Arkhangelsk
Education, Medical/history
Russia Schools, Medical/history
Teaching/methods
PubMed ID
4279090 View in PubMed
Less detail

[Organization of medical and health support for construction workers in the western portion of the Baikal-Amur mainline during the period of the expansion of operations].

https://arctichealth.org/en/permalink/ahliterature302400
Source
Sov Zdravookhr. 1975;(7):21-5.
Publication Type
Article
Date
1975
Author
Sedov KR
Potapov AI
Source
Sov Zdravookhr. 1975;(7):21-5.
Date
1975
Language
Russian
Geographic Location
Russia
Publication Type
Article
Keywords
Occupational Health Services
Occupational Medicine
Organization and Administration
Railroads
Sanitation
Siberia
PubMed ID
1209302 View in PubMed
Less detail

[Changes in blood lipids in humans during long-term ski crossing in the Extreme North].

https://arctichealth.org/en/permalink/ahliterature302399
Source
Kosm Biol Aviakosm Med. 1991 May-Jun;25(3):20-3.
Publication Type
Article
Date
1991
Author
Panin LE
Ostanina LS
Source
Kosm Biol Aviakosm Med. 1991 May-Jun;25(3):20-3.
Date
1991
Language
Russian
Publication Type
Article
Keywords
Adult
Arctic Regions
Humans
Lipoproteins/blood
Lipoproteins, HDL/blood
Lipoproteins, LDL/blood
Lipoproteins, VLDL/blood
Male
Physical Education and Training
Skiing
Sports Medicine
Time Factors
Abstract
Serum lipids were measured in the men who made two ski crosses in the Far North during polar night. The first trip, which was to train the athletes, took 17 days and the second took 38 days. In both studies, lipid mobilization and utilization increased, which led to changes in the lipid spectrum: decrease of the concentration of LDL and, in the second trip, of VLDL and HDL3, and increase of the concentration of HDL2 and cholesterol HDL. In the second trip, lipids were most intensively utilized: lipolysis enhanced and free fatty acids declined. This was also indicated by an increase of the capillary-venous difference in terms of the total fraction of LDL and VLDL as well as free fatty acids. At the end of the second trip, the positive capillary-venous difference in terms of LDL and VLDL and, accordingly, the negative capillary-venous difference in terms of HDL2 and HDL3 increased. At the end of both trips the synthesis of transport lipids grew; in the most strenuous second trip, their active utilization in the working organs was stronger.
PubMed ID
1770759 View in PubMed
Less detail

300292 records – page 1 of 15015.