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1 H NMR study and multivariate data analysis of reindeer skin tanning methods.

https://arctichealth.org/en/permalink/ahliterature291047
Source
Magn Reson Chem. 2017 Apr; 55(4):312-317
Publication Type
Journal Article
Date
Apr-2017
Author
Lizheng Zhu
Andrew J Ilott
Eleonora Del Federico
Cindie Kehlet
Torunn Klokkernes
Alexej Jerschow
Author Affiliation
Department of Chemistry, New York University, New York, NY, USA.
Source
Magn Reson Chem. 2017 Apr; 55(4):312-317
Date
Apr-2017
Language
English
Publication Type
Journal Article
Keywords
Animals
Humans
Magnetic Resonance Spectroscopy
Multivariate Analysis
Plant Extracts - chemistry
Reindeer
Seasons
Skin - chemistry
Tanning - methods
Tannins - chemistry
Vegetables - chemistry
Abstract
Reindeer skin clothing has been an essential component in the lives of indigenous people of the arctic and sub-arctic regions, keeping them warm during harsh winters. However, the skin processing technology, which often conveys the history and tradition of the indigenous group, has not been well documented. In this study, NMR spectra and relaxation behaviors of reindeer skin samples treated with a variety of vegetable tannin extracts, oils and fatty substances are studied and compared. With the assistance of principal component analysis (PCA), one can recognize patterns and identify groupings of differently treated samples. These methods could be important aids in efforts to conserve museum leather artifacts with unknown treatment methods and in the analysis of reindeer skin tanning processes. Copyright © 2016 John Wiley & Sons, Ltd.
PubMed ID
27654838 View in PubMed
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6-Bromoindole Derivatives from the Icelandic Marine Sponge Geodia barretti: Isolation and Anti-Inflammatory Activity.

https://arctichealth.org/en/permalink/ahliterature295994
Source
Mar Drugs. 2018 Nov 08; 16(11):
Publication Type
Journal Article
Date
Nov-08-2018
Author
Xiaxia Di
Caroline Rouger
Ingibjorg Hardardottir
Jona Freysdottir
Tadeusz F Molinski
Deniz Tasdemir
Sesselja Omarsdottir
Author Affiliation
Faculty of Pharmaceutical Sciences, University of Iceland, Hagi, Hofsvallagata 53, IS-107 Reykjavik, Iceland. xid1@hi.is.
Source
Mar Drugs. 2018 Nov 08; 16(11):
Date
Nov-08-2018
Language
English
Publication Type
Journal Article
Abstract
An UPLC-qTOF-MS-based dereplication study led to the targeted isolation of seven bromoindole alkaloids from the sub-Arctic sponge Geodia barretti. This includes three new metabolites, namely geobarrettin A?C (1?3) and four known compounds, barettin (4), 8,9-dihydrobarettin (5), 6-bromoconicamin (6), and l-6-bromohypaphorine (7). The chemical structures of compounds 1?7 were elucidated by extensive analysis of the NMR and HRESIMS data. The absolute stereochemistry of geobarrettin A (1) was assigned by ECD analysis and Marfey's method employing the new reagent l-Na-(1-fluoro-2,4-dinitrophenyl)tryptophanamide (l-FDTA). The isolated compounds were screened for anti-inflammatory activity using human dendritic cells (DCs). Both 2 and 3 reduced DC secretion of IL-12p40, but 3 concomitantly increased IL-10 production. Maturing DCs treated with 2 or 3 before co-culturing with allogeneic CD4? T cells decreased T cell secretion of IFN-?, indicating a reduction in Th1 differentiation. Although barettin (4) reduced DC secretion of IL-12p40 and IL-10 (IC50 values 11.8 and 21.0 µM for IL-10 and IL-12p40, respectively), maturing DCs in the presence of 4 did not affect the ability of T cells to secrete IFN-? or IL-17, but reduced their secretion of IL-10. These results indicate that 2 and 3 may be useful for the treatment of inflammation, mainly of the Th1 type.
PubMed ID
30413031 View in PubMed
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6-Bromoindole Derivatives from the Icelandic Marine Sponge Geodia barretti: Isolation and Anti-Inflammatory Activity.

https://arctichealth.org/en/permalink/ahliterature298348
Source
Mar Drugs. 2018 Nov 08; 16(11):
Publication Type
Journal Article
Date
Nov-08-2018
Author
Xiaxia Di
Caroline Rouger
Ingibjorg Hardardottir
Jona Freysdottir
Tadeusz F Molinski
Deniz Tasdemir
Sesselja Omarsdottir
Author Affiliation
Faculty of Pharmaceutical Sciences, University of Iceland, Hagi, Hofsvallagata 53, IS-107 Reykjavik, Iceland. xid1@hi.is.
Source
Mar Drugs. 2018 Nov 08; 16(11):
Date
Nov-08-2018
Language
English
Publication Type
Journal Article
Keywords
Alkaloids - chemistry - isolation & purification - pharmacology
Animals
Anti-Inflammatory Agents - chemistry - isolation & purification - pharmacology
Aquatic Organisms
CD4-Positive T-Lymphocytes - drug effects - metabolism
Cell Differentiation - drug effects
Cells, Cultured
Coculture Techniques
Dendritic Cells
Geodia
Humans
Iceland
Indoles - chemistry
Inhibitory Concentration 50
Interleukin-10 - metabolism
Interleukin-12 Subunit p40 - metabolism
Peptides, Cyclic - chemistry - isolation & purification - pharmacology
Stereoisomerism
Abstract
An UPLC-qTOF-MS-based dereplication study led to the targeted isolation of seven bromoindole alkaloids from the sub-Arctic sponge Geodia barretti. This includes three new metabolites, namely geobarrettin A?C (1?3) and four known compounds, barettin (4), 8,9-dihydrobarettin (5), 6-bromoconicamin (6), and l-6-bromohypaphorine (7). The chemical structures of compounds 1?7 were elucidated by extensive analysis of the NMR and HRESIMS data. The absolute stereochemistry of geobarrettin A (1) was assigned by ECD analysis and Marfey's method employing the new reagent l-Na-(1-fluoro-2,4-dinitrophenyl)tryptophanamide (l-FDTA). The isolated compounds were screened for anti-inflammatory activity using human dendritic cells (DCs). Both 2 and 3 reduced DC secretion of IL-12p40, but 3 concomitantly increased IL-10 production. Maturing DCs treated with 2 or 3 before co-culturing with allogeneic CD4? T cells decreased T cell secretion of IFN-?, indicating a reduction in Th1 differentiation. Although barettin (4) reduced DC secretion of IL-12p40 and IL-10 (IC50 values 11.8 and 21.0 µM for IL-10 and IL-12p40, respectively), maturing DCs in the presence of 4 did not affect the ability of T cells to secrete IFN-? or IL-17, but reduced their secretion of IL-10. These results indicate that 2 and 3 may be useful for the treatment of inflammation, mainly of the Th1 type.
PubMed ID
30413031 View in PubMed
Less detail

6-Locus HLA allele and haplotype frequencies in a population of 1075 Russians from Karelia.

https://arctichealth.org/en/permalink/ahliterature295799
Source
Hum Immunol. 2018 Nov 02; :
Publication Type
Journal Article
Date
Nov-02-2018
Author
Yvonne Hagenlocher
Beatrix Willburger
Geoffrey A Behrens
Alexander H Schmidt
Yuri Ioffe
Jürgen Sauter
Author Affiliation
DKMS German Bone Marrow Donor Center, Tübingen, Germany.
Source
Hum Immunol. 2018 Nov 02; :
Date
Nov-02-2018
Language
English
Publication Type
Journal Article
Abstract
A total of 1075 Russians from the Russian part of Karelia were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 using next generation sequencing methods. The haplotypic and allelic profiles as well as Hardy-Weinberg proportions of this population sample were evaluated. As the most frequent 6-locus haplotype, A*03:01?g?~?B*07:02?g?~?C*07:02?g?~?DRB1*15:01?g?~?DQB1*06:02?g?~?DPB1*04:01?g was identified with an estimated frequency of 3.5%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Russia Karelia" and the identifier AFN3430.
PubMed ID
30391501 View in PubMed
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6-Locus HLA allele and haplotype frequencies in a population of 1075 Russians from Karelia.

https://arctichealth.org/en/permalink/ahliterature301335
Source
Hum Immunol. 2019 Feb; 80(2):95-96
Publication Type
Journal Article
Date
Feb-2019
Author
Yvonne Hagenlocher
Beatrix Willburger
Geoffrey A Behrens
Alexander H Schmidt
Yuri Ioffe
Jürgen Sauter
Author Affiliation
DKMS German Bone Marrow Donor Center, Tübingen, Germany.
Source
Hum Immunol. 2019 Feb; 80(2):95-96
Date
Feb-2019
Language
English
Publication Type
Journal Article
Keywords
Alleles
Gene Frequency
Genetic Loci
Genetics, Population
Genotype
HLA Antigens - genetics
Haplotypes
Humans
Population Groups
Russia - ethnology
Abstract
A total of 1075 Russians from the Russian part of Karelia were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 using next generation sequencing methods. The haplotypic and allelic profiles as well as Hardy-Weinberg proportions of this population sample were evaluated. As the most frequent 6-locus haplotype, A*03:01?g?~?B*07:02?g?~?C*07:02?g?~?DRB1*15:01?g?~?DQB1*06:02?g?~?DPB1*04:01?g was identified with an estimated frequency of 3.5%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Russia Karelia" and the identifier AFN3430.
PubMed ID
30391501 View in PubMed
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8.2 ka event North Sea hydrography determined by bivalve shell stable isotope geochemistry.

https://arctichealth.org/en/permalink/ahliterature299687
Source
Sci Rep. 2019 May 01; 9(1):6753
Publication Type
Journal Article
Date
May-01-2019
Author
Juan Estrella-Martínez
Philippa L Ascough
Bernd R Schöne
James D Scourse
Paul G Butler
Author Affiliation
School of Ocean Sciences, Bangor University, Askew St., Menai Bridge, LL59 5AB, UK. juan@es-mar.com.
Source
Sci Rep. 2019 May 01; 9(1):6753
Date
May-01-2019
Language
English
Publication Type
Journal Article
Abstract
The abrupt 8.2 ka cold event has been widely described from Greenland and North Atlantic records. However, its expression in shelf seas is poorly documented, and the temporal resolution of most marine records is inadequate to precisely determine the chronology of major events. A robust hydrographical reconstruction can provide an insight on climatic reaction times to perturbations to the Atlantic Meridional Overturning Circulation. Here we present an annually-resolved temperature and water column stratification reconstruction based on stable isotope geochemistry of Arctica islandica shells from the Fladen Ground (northern North Sea) temporally coherent with Greenland ice core records. Our age model is based on a growth increment chronology obtained from four radiometrically-dated shells covering the 8290-8100?cal BP interval. Our results indicate that a sudden sea level rise (SSLR) event-driven column stratification occurred between ages 8320-8220?cal BP. Thirty years later, cold conditions inhibited water column stratification but an eventual incursion of sub-Arctic waters into the North Sea re-established density-driven stratification. The water temperatures reached their minimum of ~3.7?°C 55 years after the SSLR. Intermittently-mixed conditions were later established when the sub-Arctic waters receded.
PubMed ID
31043648 View in PubMed
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A 10-Year Follow-Up of Adiposity and Dementia in Swedish Adults Aged 70 Years and Older.

https://arctichealth.org/en/permalink/ahliterature300956
Source
J Alzheimers Dis. 2018; 63(4):1325-1335
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
2018
Author
Ilse A C Arnoldussen
Valter Sundh
Kristoffer Bäckman
Silke Kern
Svante Östling
Kaj Blennow
Henrik Zetterberg
Ingmar Skoog
Amanda J Kiliaan
Deborah R Gustafson
Author Affiliation
Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
Source
J Alzheimers Dis. 2018; 63(4):1325-1335
Date
2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adiponectin - blood
Adiposity
Aged
Aged, 80 and over
Anthropometry
Body mass index
Dementia - blood - epidemiology - pathology
Fasting
Female
Humans
Independent living
Leptin - blood
Longitudinal Studies
Male
Psychiatric Status Rating Scales
Sex Factors
Sweden - epidemiology
Waist-Hip Ratio
Abstract
Adiposity measured in mid- or late-life and estimated using anthropometric measures such as body mass index (BMI) and waist-to-hip ratio (WHR), or metabolic markers such as blood leptin and adiponectin levels, is associated with late-onset dementia risk. However, during later life, this association may reverse and aging- and dementia-related processes may differentially affect adiposity measures.
We explored associations of concurrent BMI, WHR, and blood leptin and high molecular weight adiponectin levels with dementia occurrence.
924 Swedish community-dwelling elderly without dementia, aged 70 years and older, systematically-sampled by birth day and birth year population-based in the Gothenburg city region of Sweden. The Gothenburg Birth Cohort Studies are designed for evaluating risk and protective factors for dementia. All dementias diagnosed after age 70 for 10 years were identified. Multivariable logistic regression models were used to predict dementia occurrence between 2000-2005, 2005-2010, and 2000-2010 after excluding prevalent baseline (year 2000) dementias. Baseline levels of BMI, WHR, leptin, and adiponectin were used.
Within 5 years of baseline, low BMI (
PubMed ID
29758945 View in PubMed
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A 10-year review found increasing incidence trends of emergency egg allergy reactions and food-induced anaphylaxis in children.

https://arctichealth.org/en/permalink/ahliterature292434
Source
Acta Paediatr. 2018 Jun 19; :
Publication Type
Journal Article
Date
Jun-19-2018
Author
J Österlund
A Winberg
C E West
Author Affiliation
Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Source
Acta Paediatr. 2018 Jun 19; :
Date
Jun-19-2018
Language
English
Publication Type
Journal Article
Abstract
International reports have suggested that food allergies and food-induced anaphylaxis have increased in children. We investigated the incidence of emergency food reactions over a 10-year period.
This study retrospectively reviewed the medical records of children presenting to Umeå University hospital, Sweden, with an emergency food reaction from January 1, 2006 to December 31, 2015. Cases were identified using discharge codes for allergies and anaphylaxis. Anaphylaxis cases were included if they fulfilled the international criteria.
We found emergency food allergy reactions in 519 children (58% boys) from 2006-2015 at a median age of 1.3 years. One-third were hospitalised (32%) including 71/99 cases of anaphylaxis. Milk and eggs were the most commonly identified triggers. Emergency reactions to eggs increased during the study period with a Spearman rank correlation coefficient of 0.770 (p 
PubMed ID
29920760 View in PubMed
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A 12-year National Study of Suicide by Jumping From Bridges in Norway.

https://arctichealth.org/en/permalink/ahliterature293093
Source
Arch Suicide Res. 2017 Oct-Dec; 21(4):568-576
Publication Type
Journal Article
Author
Aleksandra Sæheim
Ingebjørg Hestetun
Erlend Mork
Latha Nrugham
Lars Mehlum
Source
Arch Suicide Res. 2017 Oct-Dec; 21(4):568-576
Language
English
Publication Type
Journal Article
Keywords
Adolescent
Adult
Aged
Environment Design - statistics & numerical data
Female
Humans
Male
Middle Aged
Norway
Registries
Suicide - prevention & control - statistics & numerical data
Young Adult
Abstract
Studies from several countries suggest that erecting fences on bridges more commonly used for suicide by jumping may be an effective way of reducing the risk of suicide by jumping from these bridges. Distribution of suicides by jumping off bridges has not yet been studied on a national level in any country. This study included all suicides by jumping from high places registered in the Norwegian Cause of Death Registry (COD) in the period 1999-2010 (n = 319). Combining data from the COD registry and information from police records, 71 cases of suicide by jumping off a bridge were identified involving 36 bridges. This form of suicide constituted approximately 1% of all suicides in Norway in the period 1999-2010. Almost half of these suicides were registered at only 6 bridges. Three Norwegian bridges were secured during the observation period of this study. Two bridges had barriers installed on the full length of the bridge with 11 suicides registered before barriers were installed, and none after. On the 1 bridge that was only partially secured, no change in numbers of suicides was observed after barriers were installed. One-third of jumps from bridges occurred over land. We found that although suicide by jumping off bridges was a relatively rare event, there is a potential for saving lives by installing physical barriers on bridges that are more commonly used for suicide by jumping.
PubMed ID
27309998 View in PubMed
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15-year-old tobacco and alcohol abstainers in a drier generation: Characteristics and lifestyle factors in a Norwegian cross-sectional sample.

https://arctichealth.org/en/permalink/ahliterature300210
Source
Scand J Public Health. 2019 Jun; 47(4):439-445
Publication Type
Journal Article
Date
Jun-2019
Author
Ingeborg Lund
Janne Scheffels
Author Affiliation
Department of Alcohol, Norwegian Institute of Public Health, Tobacco and Drugs, Norway.
Source
Scand J Public Health. 2019 Jun; 47(4):439-445
Date
Jun-2019
Language
English
Publication Type
Journal Article
Keywords
Adolescent
Adolescent Behavior - psychology
Alcohol Abstinence - statistics & numerical data
Alcohol Drinking - epidemiology - psychology
Cross-Sectional Studies
Female
Humans
Leisure Activities
Life Style
Male
Norway - epidemiology
Parent-Child Relations
Parenting - psychology
Risk factors
Surveys and Questionnaires
Tobacco Use - epidemiology - psychology
Abstract
Norwegian adolescents currently drink and smoke less on average than previous cohorts. Based on cross-sectional survey data, the individual and familial characteristics of 15-year-old non-users and users of alcohol and tobacco were compared to identify correlates to abstinence.
The survey was approved by the Norwegian Social Science Service. The sample consisted of 3107 adolescents from a 2011 school-based survey, of which 848 (27.3%) did not drink alcohol nor use tobacco. Associations with leisure time activities, risk perceptions, parenting style and social factors were analysed by logistic regression.
Most of the non-drinkers were also non-users of tobacco. Abstainers (neither alcohol nor tobacco use) tended to have less unorganized and more hobby-related leisure time activities, higher risk perceptions for smoking, and monitoring or emotionally supportive parents. They more rarely reported close relationships with their best friend and were more likely to report lower occurrences of drinking and smoking among friends or siblings.
Differences in perceived parenting styles and a lower degree of unorganized leisure in the abstainer group points to monitoring and closer emotional ties between parents and children as important factors in adolescent abstinence. An implication of these results is that promoting hobby-based activities might be a useful strategy for preventing alcohol and tobacco use in young people.
PubMed ID
29671371 View in PubMed
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9690 records – page 1 of 969.