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Body composition and body fat distribution in relation to later risk of acute myocardial infarction: a Danish follow-up study.

https://arctichealth.org/en/permalink/ahliterature137399
Source
Int J Obes (Lond). 2011 Nov;35(11):1433-41
Publication Type
Article
Date
Nov-2011
Author
J G Stegger
E B Schmidt
T. Obel
T L Berentzen
A. Tjønneland
T I A Sørensen
K. Overvad
Author Affiliation
Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. Jakob.Stegger@rn.dk
Source
Int J Obes (Lond). 2011 Nov;35(11):1433-41
Date
Nov-2011
Language
English
Publication Type
Article
Keywords
Body Composition
Body Fat Distribution
Body mass index
Denmark - epidemiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction - epidemiology - etiology - physiopathology
Obesity - complications - epidemiology - physiopathology
Predictive value of tests
Proportional Hazards Models
Prospective Studies
Questionnaires
Risk factors
Abstract
Obesity is a modifiable risk factor for acute myocardial infarction (MI), but lean body mass (LBM) may also be an important factor. Low LBM may increase the risk of MI and LBM may modify the effect of obesity on MI. Thus, the inability of the classical anthropometric measures to evaluate LBM may lead to misclassification of MI risk in both lean and obese persons. We investigated the associations between incident MI and bioelectrical impedance analyses (BIA) derived measures of body composition in combination with body mass index (BMI) and anthropometric measures of body fat distribution.
From 1993 to 1997, 27?148 men and 29?863 women, aged 50 to 64 year, were recruited into the Danish prospective study Diet, Cancer and Health. During 11.9 years of follow-up we identified 2028 cases of incident MI (1487 men and 541 women). BMI, waist circumference (WC), hip circumference and BIA of body composition including body fat mass (BFM), body fat percentage and LBM were measured at baseline. We used Cox proportional hazard models with age as time axis and performed extensive control for confounding. Weight, BMI, classical estimates of abdominal obesity and BIA estimates of obesity showed significant positive associations with incident MI. However, BFM adjusted for WC showed no association. Low LBM was associated with a higher risk of incident MI in both genders, and high LBM was associated with a higher risk in men.
Obesity was positively associated with MI. Estimates of obesity achieved by BIA seemed not to add additional information to classical anthropometric measures regarding MI risk. Both high and low LBM may be positively associated with MI.
PubMed ID
21285940 View in PubMed
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Long-term weight changes in obese young adult men and subsequent all-cause mortality.

https://arctichealth.org/en/permalink/ahliterature119552
Source
Int J Obes (Lond). 2013 Jul;37(7):1020-5
Publication Type
Article
Date
Jul-2013
Author
E. Zimmermann
T L Berentzen
L. Angquist
C. Holst
T I A Sørensen
Author Affiliation
Institute of Preventive Medicine, Copenhagen University Hospitals, Frederiksberg Hospital, Frederiksberg, Denmark.
Source
Int J Obes (Lond). 2013 Jul;37(7):1020-5
Date
Jul-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age of Onset
Aged
Body mass index
Body Weight
Denmark - epidemiology
Follow-Up Studies
Humans
Life Style
Male
Middle Aged
Obesity - complications - mortality
Prevalence
Proportional Hazards Models
Risk factors
Time Factors
Weight Gain
Weight Loss
Young Adult
Abstract
Although the expectation is that weight gain increases mortality and weight loss among those overweight reduces mortality, results on weight gain and mortality in young adults are conflicting, and weight loss is less explored. We investigated the association between long-term weight change and all-cause mortality in a broad range of body mass index (BMI) in young men.
Among 362200 Danish draftees, examined between 1943 and 1977, all obese (BMI ?31.0?kg?m(-2); n=1930), and a random 1% sample of the others (n=3601) were identified at a mean age of 20 years (range: 18-25 years). All the obese and half the controls were re-examined between 4 and 40 years later (mean age 35 years). Weight changes were defined as: weight loss 0.1?kg?m(-2) per year. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox regression.
Among the 908 obese and 1073 controls followed for 30 years after re-examination 220 and 232 died. HR of the weight stable obese was 2.32 (CI: 1.56-3.44) compared with the weight stable controls. In the obese cohort there was no association between weight loss, adjusted for initial BMI, and mortality (HR: 0.99; CI: 0.68-1.45) compared with weight stable obese. Too few controls lost weight to allow assessment of weight loss. Weight gain was associated with increased mortality in the obese (HR: 1.50; CI: 1.07-2.10) and controls (HR: 1.54; CI: 1.14-2.09) compared with weight stable obese and controls, respectively. Neither the time between the two examinations, life-style factors nor exclusion of diseased individuals influenced the results.
Although there were increased mortality of the weight-stable obese compared with controls, there was no association between weight loss and mortality in the obese. Weight gain increased mortality regardless of the initial weight.
PubMed ID
23090576 View in PubMed
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