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13535 records – page 1 of 1354.

1H MRS studies in the Finnish boron neutron capture therapy project: detection of 10B-carrier, L-p-boronophenylalanine-fructose.

https://arctichealth.org/en/permalink/ahliterature172386
Source
Eur J Radiol. 2005 Nov;56(2):154-9
Publication Type
Article
Date
Nov-2005
Author
M. Timonen
L. Kankaanranta
N. Lundbom
J. Collan
A. Kangasmäki
M. Kortesniemi
A-M Häkkinen
A. Lönngren
S. Karjalainen
M. Rasilainen
J. Leinonen
T. Huitti
J. Jääskeläinen
M. Kouri
S. Savolainen
S. Heikkinen
Author Affiliation
Department of Physical Sciences, University of Helsinki, POB 64, FIN-00014, Helsinki, Finland.
Source
Eur J Radiol. 2005 Nov;56(2):154-9
Date
Nov-2005
Language
English
Publication Type
Article
Keywords
Adult
Aged
Boron - therapeutic use
Boron Compounds - analysis - blood
Boron Neutron Capture Therapy
Brain Neoplasms - pathology - radiotherapy
Carcinoma - pathology - radiotherapy
Female
Finland
Fructose - analogs & derivatives - analysis - blood
Glioblastoma - pathology - radiotherapy
Humans
Hydrogen
Isotopes - therapeutic use
Magnetic Resonance Spectroscopy - methods
Male
Neoplasm Recurrence, Local - pathology - radiotherapy
Paranasal Sinus Neoplasms - pathology - radiotherapy
Phantoms, Imaging
Plasma
Radiopharmaceuticals - therapeutic use
Abstract
This article summarizes the current status of 1H MRS in detecting and quantifying a boron neutron capture therapy (BNCT) boron carrier, L-p-boronophenylalanine-fructose (BPA-F) in vivo in the Finnish BNCT project. The applicability of 1H MRS to detect BPA-F is evaluated and discussed in a typical situation with a blood containing resection cavity within the gross tumour volume (GTV). 1H MRS is not an ideal method to study BPA concentration in GTV with blood in recent resection cavity. For an optimal identification of BPA signals in the in vivo 1H MR spectrum, both pre- and post-infusion 1H MRS should be performed. The post-infusion spectroscopy studies should be scheduled either prior to or, less optimally, immediately after the BNCT. The pre-BNCT MRS is necessary in order to utilise the MRS results in the actual dose planning.
PubMed ID
16233888 View in PubMed
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A 1-year follow-up of prescribing patterns of analgesics in primary health care.

https://arctichealth.org/en/permalink/ahliterature224422
Source
J Clin Pharm Ther. 1992 Feb;17(1):43-7
Publication Type
Article
Date
Feb-1992
Author
R. Ahonen
H. Enlund
V. Pakarinen
S. Riihimäki
Author Affiliation
Department of Social Pharmacy, University of Kuopio, Finland.
Source
J Clin Pharm Ther. 1992 Feb;17(1):43-7
Date
Feb-1992
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Analgesics
Drug Prescriptions - statistics & numerical data
Female
Finland
Humans
Male
Middle Aged
Primary Health Care - trends
Abstract
The prescription of analgesics and anti-inflammatory drugs (analgesics) was studied using computerized patient records from a Finnish health centre with a population base of some 27,000 inhabitants. A random sample of every fifth patient visiting the health centre in 1986 was chosen. This study sample consisted of 4,577 patients with 17,021 physician contacts and altogether 14,035 prescriptions during the 1-year follow-up: of these analgesics comprised 14.8%. The proportion of the study population who received at least one analgesic prescription was 23 +/- 1.2% (95% CI). The use of physician contacts as a base revealed 10.7 +/- 0.5% (95% CI) of the contacts with an analgesic prescription. The exposure to analgesics among males increased with age from 17% for those aged 15-34 years to 34% for those aged 75 years or more. Among women, exposure to analgesics increased from 17% (15-34 years) to 41% (75 years or more). Most of patients who received analgesic prescriptions were incidental users (one or two analgesic prescriptions per year). Only 4% of women and 3% of men were categorized as heavy users of analgesics (seven or more analgesic prescriptions per year). The proportion of heavy users increased with age and was highest in the oldest age-group (75 years or more). In order to make informed policy judgements about drug use in society, we need routine sales statistics and patient-specific drug-use data such as those presented in this paper.
PubMed ID
1548311 View in PubMed
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A 2-year self-help smoking cessation manual intervention among middle-aged Finnish men: an application of the transtheoretical model.

https://arctichealth.org/en/permalink/ahliterature217852
Source
Prev Med. 1994 Jul;23(4):507-14
Publication Type
Article
Date
Jul-1994
Author
U E Pallonen
L. Leskinen
J O Prochaska
C J Willey
R. Kääriäinen
J T Salonen
Author Affiliation
Cancer Prevention Research Center, University of Rhode Island, Kingston 02881.
Source
Prev Med. 1994 Jul;23(4):507-14
Date
Jul-1994
Language
English
Publication Type
Article
Keywords
Adult
Analysis of Variance
Chi-Square Distribution
Confounding Factors (Epidemiology)
Finland
Humans
Longitudinal Studies
Male
Manuals as Topic
Middle Aged
Risk factors
Self Care
Smoking Cessation
Abstract
A 2-year self-help manual smoking cessation intervention was conducted among a panel of middle-aged Finnish men (n = 265) who were recruited proactively in a longitudinal cardiovascular risk factor surveillance study.
Intervention utilized the stages of change concept of the transtheoretical model. The stages were assessed in the treatment condition at baseline of the cessation study and after that by mail every sixth month. Assessments were followed by an immediate mailing of a stage-based self-help manual matching the stage of change at that time. A usual care group was assessed annually but received no treatment.
A significant time x intervention effect (P
PubMed ID
7971879 View in PubMed
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3'-UTR poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer with nearly perfect sensitivity.

https://arctichealth.org/en/permalink/ahliterature273744
Source
Fam Cancer. 2015 Sep;14(3):449-53
Publication Type
Article
Date
Sep-2015
Author
Johanna Kondelin
Sari Tuupanen
Alexandra E Gylfe
Mervi Aavikko
Laura Renkonen-Sinisalo
Heikki Järvinen
Jan Böhm
Jukka-Pekka Mecklin
Claus L Andersen
Pia Vahteristo
Esa Pitkänen
Lauri A Aaltonen
Source
Fam Cancer. 2015 Sep;14(3):449-53
Date
Sep-2015
Language
English
Publication Type
Article
Keywords
3' Untranslated Regions
Calmodulin-Binding Proteins - genetics
Colorectal Neoplasms - genetics
Denmark
Finland
Humans
Microsatellite Instability
Polyribonucleotides - genetics
RNA-Binding Proteins - genetics
Repetitive Sequences, Nucleic Acid
Abstract
Approximately 15% of colorectal cancers exhibit instability of short nucleotide repeat regions, microsatellites. These tumors display a unique clinicopathologic profile and the microsatellite instability status is increasingly used to guide clinical management as it is known to predict better prognosis as well as resistance to certain chemotherapeutics. A panel of five repeats determined by the National Cancer Institute, the Bethesda panel, is currently the standard for determining the microsatellite instability status in colorectal cancer. Recently, a quasimonomorphic mononucleotide repeat 16T/U at the 3' untranslated region of the Ewing sarcoma breakpoint region 1 gene was reported to show perfect sensitivity and specificity in detecting mismatch repair deficient colorectal, endometrial, and gastric cancers in two independent populations. To confirm this finding, we replicated the analysis in 213 microsatellite unstable colorectal cancers from two independent populations, 148 microsatellite stable colorectal cancers, and the respective normal samples by PCR and fragment analysis. The repeat showed nearly perfect sensitivity for microsatellite unstable colorectal cancer as it was altered in 212 of the 213 microsatellite unstable (99.5%) and none of the microsatellite stable colorectal tumors. This repeat thus represents the first potential single marker for detecting microsatellite instability.
PubMed ID
25930744 View in PubMed
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The 3-year follow-up study in a block of flats - experiences in the use of the Finnish indoor climate classification.

https://arctichealth.org/en/permalink/ahliterature185305
Source
Indoor Air. 2003 Jun;13(2):136-47
Publication Type
Article
Date
Jun-2003
Author
M. Tuomainen
A. Tuomainen
J. Liesivuori
A-L Pasanen
Author Affiliation
Department of Environmental Sciences, University of Kuopio, Finland. marja.tuomainen@hengitysliitto.fi
Source
Indoor Air. 2003 Jun;13(2):136-47
Date
Jun-2003
Language
English
Publication Type
Article
Keywords
Air pollution, indoor
Allergens - analysis
Ammonia - analysis
Asthma - prevention & control
Bacteria
Carbon Dioxide - analysis
Carbon Monoxide - analysis
Construction Materials - standards
Finland
Follow-Up Studies
Housing - standards
Humans
Humidity
Questionnaires
Spores, Fungal
Temperature
Abstract
Indoor climate of two new blocks of flats was investigated. The case building was built for people with respiratory diseases by following the instructions of the Finnish Classification of Indoor Climate, Construction and Finishing Materials, while the control building was built using conventional building technology. The main indoor air parameters (temperature, relative humidity and levels of CO, CO2, ammonia, total volatile organic compounds, total suspended particles, fungal spores, bacteria and cat, dog and house dust mite allergens) were measured in six apartments of both the buildings on five occasions during the 3-year occupancy. In addition, a questionnaire to evaluate symptoms of the occupants and their satisfaction with their home environment was conducted in connection with indoor air quality (IAQ) measurements. The levels of indoor air pollutants in the case building were, in general, lower than those in the control building. In addition, the asthmatic occupants informed that their symptoms had decreased during the occupancy in the case building. This case study showed that high IAQ is possible to reach by careful design, proper materials and equipment and on high-quality construction with reasonable additional costs. In addition, the study indicated that good IAQ can also be maintained during the occupancy, if sufficient information on factors affecting IAQ and guidance on proper use and care of equipment are available for occupants.
PubMed ID
12756007 View in PubMed
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A 3 year follow-up study of health care students' sense of coherence and related smoking, drinking and physical exercise factors.

https://arctichealth.org/en/permalink/ahliterature186071
Source
Int J Nurs Stud. 2003 May;40(4):383-8
Publication Type
Article
Date
May-2003
Author
Merja Kuuppelomäki
Pekka Utriainen
Author Affiliation
Research and Development Centre for Social Welfare and Health, Seinäjoki Polytechnic, Koskenalantie 16 Seinäjoki Fin-60220, Finland. merja.kuuppelomaki@seamk.fi
Source
Int J Nurs Stud. 2003 May;40(4):383-8
Date
May-2003
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alcohol Drinking - psychology
Attitude of Health Personnel
Attitude to Health
Educational Status
Exercise - psychology
Female
Finland
Follow-Up Studies
Health Behavior
Health Knowledge, Attitudes, Practice
Humans
Internal-External Control
Male
Pilot Projects
Questionnaires
Self Efficacy
Smoking - psychology
Students, Health Occupations - psychology
Abstract
The purpose of the study was to describe the sense of coherence (SOC) of three groups of Finnish polytechnic students (n=287) at the beginning of their studies and to follow it during a period of 3 year amongst the health care students (n=63) of this group. The associations between SOC and smoking, drinking and physical exercise were also studied. The data were collected with a questionnaire which included Antonovsky's (Adv. Nurs. Sci. 1(1983)37) SOC scale. Data analysis was with SPSS statistical software. The students showed a strong sense of coherence at the beginning of their studies. Physical activity was related to the strength of SOC, but no association was found with smoking and drinking. Health care students showed a stronger SOC at the beginning of their studies than the two other groups. During the follow-up focused on the health care students, SOC weakened in 6%, remained unchanged in 65% and strengthened in 32% of the participants. Smoking, drinking and physical exercise showed no association with these changes. Future research should be focused on identifying factors that are related to SOC during education.
PubMed ID
12667515 View in PubMed
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A 3-year longitudinal caries study of permanent tooth surfaces at risk in Finnish school children.

https://arctichealth.org/en/permalink/ahliterature239564
Source
Caries Res. 1985;19(3):271-7
Publication Type
Article
Date
1985

5- and 10-year mortality in a rural middle-aged population at Haapavesi, Northern Finland, with special reference to ischaemic heart disease.

https://arctichealth.org/en/permalink/ahliterature55583
Source
Cor Vasa. 1987;29(4):261-8
Publication Type
Article
Date
1987
Author
H J Juustila
J T Takkunen
M. Lilja
A J Jounela
M. Linnaluoto
M. Raudaskoski
Author Affiliation
Department of Medicine, University of Oulu, Finland.
Source
Cor Vasa. 1987;29(4):261-8
Date
1987
Language
English
Publication Type
Article
Keywords
Adult
Cerebral Infarction - mortality
Coronary Disease - mortality
Female
Finland
Humans
Male
Middle Aged
Risk factors
Rural Population
Sex Factors
Abstract
As a part of a larger prospective population study of ischaemic heart disease (IHD) the causes of 5- and 10-year mortality were analysed in 1554 rural inhabitants aged 40 to 59 years (90.0% of the population of this age group) in Northern Finland. The total mortality in 5 years was 2.3% among women and 6.3% among men. The respective 10-year mortality figures were 6.2% and 13.4%. The proportion of IHD as a cause of these deaths among women was 35% and 34% in 5 and 10 years, respectively; among men 46% and 46% of the deaths were due to IHD in 5 and 10 years, respectively. Among women the proportion of strokes was 22% and 19% in 5 and 10 years, respectively; the other causes of death among women amounted to 43% and 47% in 5 and 10 years, respectively. Among men, strokes resulted in the death of 14% and 7% in 5 and 10 years, respectively, the other causes of death amounted to 40% and 47% in 5 and 10 years, respectively. The incidence of IHD as a cause of death among women was higher than previously reported.
PubMed ID
3677715 View in PubMed
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A 5-year follow-up of occlusal status and radiographic findings in mandibular condyles of the elderly.

https://arctichealth.org/en/permalink/ahliterature187416
Source
Int J Prosthodont. 2002 Nov-Dec;15(6):539-43
Publication Type
Article
Author
Kaija Hiltunen
Miira M Vehkalahti
Jaakko S Peltola
Anja Ainamo
Author Affiliation
Department of Prosthodontics, Institute of Dentistry, University of Helsinki, Finland. kaija.hiltunen@helsinki.fi
Source
Int J Prosthodont. 2002 Nov-Dec;15(6):539-43
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
Aged, 80 and over
Chi-Square Distribution
Confidence Intervals
Dentition
Denture, Partial, Fixed
Dentures
Dislocations - classification - radiography
Female
Finland
Follow-Up Studies
Humans
Jaw, Edentulous, Partially - classification - rehabilitation
Logistic Models
Male
Mandibular Condyle - radiography
Odds Ratio
Osteoarthritis - classification - radiography
Osteosclerosis - classification - radiography
Radiography, Panoramic
Risk factors
Sex Factors
Temporomandibular Joint Disorders - classification - radiography
Abstract
The aim of the present 5-year follow-up was to clarify the nature of occlusal support status and radiographic changes in condyles of the elderly, and the association between these two variables.
The present study is part of a comprehensive medical survey of a random sample born in 1904, 1909, and 1914. A total of 364 subjects living in Helsinki participated in the dental part of the examination during 1990 to 1991, and after 5 years a total of 103 were reexamined. Comprehensive data on occlusal support status were available for 94 subjects, and radiographic data were available for 88 subjects. Occlusal support status was assessed on the basis of the Eichner index, radiographic changes were assessed from panoramic radiographs, and symptoms of temporomandibular disorders were assessed using Helkimo's anamnestic index.
The most frequent radiographic finding in the mandibular joint was flattening of the articular surface of the condyle associated with osteoarthrosis, found at baseline in 17% and during follow-up in 13% of the subjects. During the 5-year follow-up, Eichner index for natural dentition remained unaltered in 94% of the subjects and in 85% of the subjects when removable dentures were included. There were no radiographic changes in 92% of the cases. No differences based on age or gender were found. A logistic regression model revealed associations between the selected baseline factors. The odds ratio for baseline Helkimo's anamnestic index was 4.1, 5.7 for Eichner index with the support of removable dentures, and 356 for radiographic findings.
Radiographic changes in condyles of elderly people were small during the 5-year follow-up, but baseline radiographic findings, Helkimo's anamnestic index, and Eichner index with removable dentures were risk factors for radiographic findings at the end of the follow-up.
PubMed ID
12475158 View in PubMed
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13535 records – page 1 of 1354.