Skip header and navigation

Refine By

4 records – page 1 of 1.

Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism--the Finnish Diabetes Prevention Study.

https://arctichealth.org/en/permalink/ahliterature144157
Source
Nutr Metab Cardiovasc Dis. 2011 Sep;21(9):691-8
Publication Type
Article
Date
Sep-2011
Author
Lappalainen T
Kolehmainen M
Schwab US
Tolppanen AM
Stancáková A
Lindström J
Eriksson JG
Keinänen-Kiukaanniemi S
Aunola S
Ilanne-Parikka P
Herder C
Koenig W
Gylling H
Kolb H
Tuomilehto J
Kuusisto J
Uusitupa M
Author Affiliation
School of Public Health and Clinical Nutrition, Department of Clinical Nutrition and Food and Health Research Centre, University of Kuopio, Kuopio, Finland. tiina.lappalainen@uef.fi
Source
Nutr Metab Cardiovasc Dis. 2011 Sep;21(9):691-8
Date
Sep-2011
Language
English
Publication Type
Article
Keywords
Aged
Blood Glucose - analysis - metabolism
C-Reactive Protein - analysis
Cardiovascular Diseases - epidemiology - genetics - pathology
Cross-Sectional Studies
Female
Finland - epidemiology
Follow-Up Studies
Genotype
Glucose Intolerance - genetics
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Proteins - genetics - metabolism
Risk factors
Abstract
The common single nucleotide polymorphism (SNP) in the FTO (fat mass and obesity associated) gene has been consistently associated with an increased risk of obesity. We investigated whether the SNP rs9939609 (T/A) of the FTO is associated with risk factors of cardiovascular diseases (CVD), including serum levels of C - reactive protein (CRP), the chemokine RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted; CCL5), and serum and lipoprotein lipids in the Finnish Diabetes Prevention Study (DPS). Furthermore, we examined whether the rs9939609 increased the CVD risk in the DPS and if these results could be replicated in a larger cross-sectional population-based random sample of Finnish men (the METSIM).
In the DPS, altogether 490 (BMI=25kg/m(2)) subjects with impaired glucose tolerance were genotyped for rs9939609. Cardiovascular morbidity and mortality data were collected during the median follow-up of 10.2 years. The replication study was a population-based cross-sectional study of 6214 men. In the DPS, the AA genotype of rs9939609 was associated, independently of BMI, with increased RANTES (p=0.002) and decreased HDL cholesterol concentrations (p=0.007) in men. During the follow-up, the AA genotype was associated with an adjusted 2.09-fold risk (95% CI 1.17-3.73, p=0.013) of CVD in men. In the METSIM Study, the association with a history of myocardial infarction was replicated in the subgroup of men with type 2 diabetes.
We suggest that the variation in the FTO gene may contribute to the development of CVD in men with an abnormal glucose metabolism.
PubMed ID
20400278 View in PubMed
Less detail

Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study.

https://arctichealth.org/en/permalink/ahliterature174146
Source
Diabetes. 2005 Jul;54(7):2256-60
Publication Type
Article
Date
Jul-2005
Author
Laukkanen O
Lindström J
Eriksson J
Valle TT
Hämäläinen H
Ilanne-Parikka P
Keinänen-Kiukaanniemi S
Tuomilehto J
Uusitupa M
Laakso M
Author Affiliation
Department of Medicine, University of Kuopio, 70210 Kuopio, Finland.
Source
Diabetes. 2005 Jul;54(7):2256-60
Date
Jul-2005
Language
English
Publication Type
Article
Keywords
Analysis of Variance
Diabetes Mellitus, Type 2 - genetics - prevention & control
Disease Progression
Finland
Genotype
Glucose Intolerance - genetics
Glucose Transporter Type 2
Humans
Monosaccharide Transport Proteins - genetics
Multivariate Analysis
Obesity - genetics
Polymorphism, Single Nucleotide
Risk factors
Abstract
Impaired insulin secretion is a fundamental defect in type 2 diabetes. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1alpha], HNF4A, GIP, and GLP1R) are associated with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in participants of the Finnish Diabetes Prevention Study. With the exception of SLC2A2, other genes were not associated with the risk of type 2 diabetes. All four SNPs of SLC2A2 predicted the conversion to diabetes, and rs5393 (AA genotype) increased the risk of type 2 diabetes in the entire study population by threefold (odds ratio 3.04, 95% CI 1.34-6.88, P = 0.008). The risk for type 2 diabetes in the AA genotype carriers was increased in the control group (5.56 [1.78-17.39], P = 0.003) but not in the intervention group. We conclude that the SNPs of SLC2A2 predict the conversion to diabetes in obese subjects with IGT.
PubMed ID
15983230 View in PubMed
Less detail

Diabetes and impaired glucose metabolism is associated with more cold-related cardiorespiratory symptoms.

https://arctichealth.org/en/permalink/ahliterature302314
Source
Diabetes Research and Clinical Practice. 2017 Jul;129:116-125. doi: 10.1016/j.diabres.2017.04.022. Epub 2017 May 4.
Publication Type
Article
Date
2017
Author
Ikäheimo TM
Jokelainen J
Hassi J
Hiltunen L
Keinänen-Kiukaanniemi S
Laatikainen T
Jousilahti P
Peltonen M
Moilanen L
Saltevo J
Näyhä S
Source
Diabetes Research and Clinical Practice. 2017 Jul;129:116-125. doi: 10.1016/j.diabres.2017.04.022. Epub 2017 May 4.
Date
2017
Language
English
Geographic Location
Finland
Publication Type
Article
Keywords
Aged
Blood glucose
Cardiovascular diseases
Epidemiology
Cold Temperature
Metabolism
Adverse effects
Diabetes Mellitus, Type 2
Complications
Female
Glucose Intolerance
Glucose Tolerance Test
Humans
Male
Middle Aged
Risk factors
Abstract
AIMS: Diabetes and impaired glucose metabolism cause metabolic, neural and circulatory disturbances that may predispose to adverse cooling and related symptoms during the cold season. This study assessed the prevalence of cold-related cardiorespiratory symptoms in the general population according to glycaemic status.
METHODS: The study population consisted of 2436 men and 2708 women aged 45-74years who participated in the National FINRISK cold sub-studies in 2002 and 2007. A questionnaire assessed cold-related symptoms (respiratory, cardiac, peripheral circulation). Glycaemic status was determined based on fasting blood glucose, oral glucose tolerance tests or reported diagnosis of diabetes and categorized into normal glucose metabolism, impaired fasting blood glucose, impaired glucose tolerance, screening-detected type 2 diabetes and type 2 diabetes.
RESULTS: Type 2 diabetes was associated with increased odds for cold-related dyspnoea [Adjusted OR 1.72 (95% CI, 1.28-2.30)], chest pain [2.10 (1.32-3.34)] and respiratory symptoms [1.85 (1.44-2.38)] compared with normal glucose metabolism. Screened type 2 diabetes showed increased OR for cold-related dyspnoea [1.36 (1.04-1.77)], cough [1.41 (1.06-1.87)] and cardiac symptoms [1.51 (1.04-2.20)]. Worsening of glycaemic status was associated with increased odds for cold-related dyspnoea (from 1.16 in impaired fasting glucose to 1.72 in type 2 diabetes, P=0.000), cough (1.02-1.27, P=0.032), chest pain (1.28-2.10, P=0.006), arrhythmias (0.87-1.74, P=0.020), cardiac (1.11-1.99, P=0.000), respiratory (1.14-1.84, P=0.000) and all symptoms (1.05-1.66, P=0.003).
CONCLUSIONS: Subjects with diabetes and pre-diabetes experience more cold-related cardiorespiratory symptoms and need instructions for proper protection from cold weather to reduce adverse health effects.
PubMed ID
28521195 View in PubMed
Less detail

Cold-related cardiorespiratory symptoms among subjects with and without hypertension: the National FINRISK Study 2002.

https://arctichealth.org/en/permalink/ahliterature301017
Source
European Journal of Public Health. 2014 Apr;24(2):237-43. doi: 10.1093/eurpub/ckt078. Epub 2013 Jun 22.
Publication Type
Article
Date
2014
Author
Ikäheimo TM
Lehtinen T
Antikainen R
Jokelainen J
Näyhä S
Hassi J
Keinänen-Kiukaanniemi S
Laatikainen T
Jousilahti P
Jaakkola JJ
Source
European Journal of Public Health. 2014 Apr;24(2):237-43. doi: 10.1093/eurpub/ckt078. Epub 2013 Jun 22.
Date
2014
Language
English
Geographic Location
Finland
Publication Type
Article
Keywords
Adult
Aged
Cardiovascular diseases
Complications
Epidemiology
Cold Temperature
Female
Finland
Humans
Hypertension
Male
Middle Aged
Prevalence
Risk factors
Surveys and Questionnaires
Abstract
BACKGROUND: Exposure to cold weather increases blood pressure (BP) and may aggravate the symptoms and influence the prognosis of subjects with a diagnosis of hypertension. We tested the hypothesis that subjects with hypertension alone or in combination with another cardiovascular disease (CVD) experience cold-related cardiorespiratory symptoms more commonly than persons without hypertension. This information is relevant for proper treatment and could serve as an indicator for predicting wintertime morbidity and mortality.
METHODS: A self-administered questionnaire inquiring of cold-related symptoms was obtained from 6591 men and women aged 25-74 yrs of the FINRISK Study 2002 population. BP was measured in association with clinical examinations. Symptom prevalence was compared between subjects with diagnosed hypertensive disease with (n = 395) or without (n = 764) another CVD, untreated diagnosed hypertension (n = 1308), measured high BP (n = 1070) and a reference group (n = 2728) with normal BP.
RESULTS: Hypertension in combination with another CVD was associated with increased cold-related dyspnoea (men: adjusted odds ratio 3.94, 95% confidence interval 2.57-6.02)/women: 4.41, 2.84-6.86), cough (2.64, 1.62-4.32/4.26, 2.60-6.99), wheezing (2.51, 1.42-4.43/;3.73, 2.08-6.69), mucus excretion (1.90, 1.24-2.91/2.53, 1.54-4.16), chest pain (22.5, 9.81-51.7/17.7, 8.37-37.5) and arrhythmias (43.4, 8.91-211/8.99, 3.99-20.2), compared with the reference group. Both diagnosed treated hypertension and untreated hypertension and measured high BP resulted in increased cardiorespiratory symptoms during the cold season.
CONCLUSION: Hypertension alone and together with another CVD is strongly associated with cold-related cardiorespiratory symptoms. As these symptoms may predict adverse health events, hypertensive patients need customized care and advice on how to cope with cold weather.
PubMed ID
23794677 View in PubMed
Less detail