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300254 records – page 1 of 30026.

Total mercury and methyl-mercury contents and accumulation in polar microbial mats.

https://arctichealth.org/en/permalink/ahliterature263558
Source
Sci Total Environ. 2015 Mar 15;509-510:145-53
Publication Type
Article
Date
Mar-15-2015
Author
Antonio Camacho
Carlos Rochera
Raphaëlle Hennebelle
Christophe Ferrari
Antonio Quesada
Source
Sci Total Environ. 2015 Mar 15;509-510:145-53
Date
Mar-15-2015
Language
English
Publication Type
Article
Keywords
Arctic Regions
Biofilms
Environmental monitoring
Mercury - analysis
Methylmercury compounds - analysis
Water Microbiology
Water Pollutants, Chemical - analysis
Abstract
Although polar regions are considered isolated and pristine areas, the organisms that inhabit these zones are exposed to global pollution. Heavy metals, such as mercury, are global pollutants and can reach almost any location on Earth. Mercury may come from natural, volcanic or geological sources, or result from anthropogenic sources, in particular industrial or mining activities. In this study, we have investigated one of the most prominent biological non-marine communities in both polar regions, microbial mats, in terms of their Hg and methyl-mercury (MeHg) concentrations and accumulation capacities. The main hypotheses posed argued on the importance of different factors, and to test them, we have measured Hg concentrations in microbial mats that were collected from 6 locations in different ecological situations. For this purpose, the direct anthropogenic impacts, volcanic influences, proximity to the seashore, latitudinal gradients and C contents were investigated. Our results show that, other than the direct anthropogenic influence, none of the other hypotheses alone satisfactorily explains the Hg content in microbial mats. In contrast, the MeHg contents were noticeably different between the investigated locations, with a higher proportion of MeHg on the McMurdo Ice Shelf (Antarctica) and a lower proportion on Ward Hunt Island (High Arctic). Furthermore, our results from in situ experiments indicated that the microbial mats from South Shetland Islands could quickly accumulate (48 h) Hg when Hg dissolved salts were supplied. Over short-term periods, these mats do not transform Hg into MeHg under field conditions.
PubMed ID
25240505 View in PubMed
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Povl Krogsgaard-Larsen: a giant in medicinal chemistry research.

https://arctichealth.org/en/permalink/ahliterature263559
Source
Neurochem Res. 2014 Oct;39(10):1847-9
Publication Type
Article
Date
Oct-2014
Author
Klaus P Bøgesø
Source
Neurochem Res. 2014 Oct;39(10):1847-9
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Chemistry, Pharmaceutical
Denmark
History, 20th Century
History, 21st Century
PubMed ID
25227749 View in PubMed
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Farmers without borders-genetic structuring in century old barley (Hordeum vulgare).

https://arctichealth.org/en/permalink/ahliterature263560
Source
Heredity (Edinb). 2015 Feb;114(2):195-206
Publication Type
Article
Date
Feb-2015
Author
N E G Forsberg
J. Russell
M. Macaulay
M W Leino
J. Hagenblad
Source
Heredity (Edinb). 2015 Feb;114(2):195-206
Date
Feb-2015
Language
English
Publication Type
Article
Keywords
Agriculture
Biological Evolution
DNA, Plant - genetics
Finland
Genetics, Population
Genotype
Hordeum - genetics
Linkage Disequilibrium
Norway
Phylogeography
Polymorphism, Single Nucleotide
Principal Component Analysis
Sweden
Abstract
The geographic distribution of genetic diversity can reveal the evolutionary history of a species. For crop plants, phylogeographic patterns also indicate how seed has been exchanged and spread in agrarian communities. Such patterns are, however, easily blurred by the intense seed trade, plant improvement and even genebank conservation during the twentieth century, and discerning fine-scale phylogeographic patterns is thus particularly challenging. Using historical crop specimens, these problems are circumvented and we show here how high-throughput genotyping of historical nineteenth century crop specimens can reveal detailed geographic population structure. Thirty-one historical and nine extant accessions of North European landrace barley (Hordeum vulgare L.), in total 231 individuals, were genotyped on a 384 single nucleotide polymorphism assay. The historical material shows constant high levels of within-accession diversity, whereas the extant accessions show more varying levels of diversity and a higher degree of total genotype sharing. Structure, discriminant analysis of principal components and principal component analysis cluster the accessions in latitudinal groups across country borders in Finland, Norway and Sweden. FST statistics indicate strong differentiation between accessions from southern Fennoscandia and accessions from central or northern Fennoscandia, and less differentiation between central and northern accessions. These findings are discussed in the context of contrasting historical records on intense within-country south to north seed movement. Our results suggest that although seeds were traded long distances, long-term cultivation has instead been of locally available, possibly better adapted, genotypes.
PubMed ID
25227257 View in PubMed
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Renal function is a determinant of subjective well-being in active seniors but not in patients with subjective memory complaints.

https://arctichealth.org/en/permalink/ahliterature263561
Source
BMC Res Notes. 2014;7:647
Publication Type
Article
Date
2014
Author
Lovisa A Olsson
Nils-Olof Hagnelius
Torbjörn K Nilsson
Source
BMC Res Notes. 2014;7:647
Date
2014
Language
English
Publication Type
Article
Keywords
Affect
Age Factors
Aged
Aged, 80 and over
Aging - psychology
Anxiety - diagnosis - psychology
Biological Markers - blood
Creatinine - blood
Cystatin C - blood
Depression - diagnosis - psychology
Female
Geriatric Assessment
Glomerular Filtration Rate
Humans
Kidney - physiopathology
Kidney Diseases - diagnosis - physiopathology - psychology
Male
Memory
Memory Disorders - diagnosis - physiopathology - psychology
Middle Aged
Quality of Life
Risk factors
Sex Factors
Sweden
Abstract
During our whole life span, factors influencing health and functioning are accumulated. In chronic kidney disease, quality of life is adversely affected. We hypothesized that biomarkers of renal function could also be determinants of subjective well-being (SWB) in Swedish elderly subjects. SWB was assessed by the Psychological General Well-Being index (PGWB index) in two study groups: Active seniors (AS) consisted of community-dwelling elderly Swedes leading an active life (n?=?389), and the DGM cohort (n?=?300) consisted of subjects referred to the Memory Unit at the Department of Geriatrics for memory problems, Serum creatinine, cystatin C, and eGFR (CKD-EPI) were used as biomarkers of renal function.
There were no significant differences in cystatin C and eGFR values between the two cohorts: cystatin C medians 0.88 vs 0.86 mg/L and eGFR 73 vs 80 mL/min/1.73 m2 (AS vs DGM). In the AS cohort cystatin C was negatively related to PGWB index in women (P?
Notes
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PubMed ID
25219531 View in PubMed
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Fatal intoxications associated with the designer opioid AH-7921.

https://arctichealth.org/en/permalink/ahliterature263562
Source
J Anal Toxicol. 2014 Oct;38(8):599-604
Publication Type
Article
Date
Oct-2014
Author
R. Kronstrand
G. Thelander
D. Lindstedt
M. Roman
F C Kugelberg
Source
J Anal Toxicol. 2014 Oct;38(8):599-604
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Adult
Analgesics, Opioid - toxicity
Antidepressive Agents - administration & dosage
Autopsy
Benzamides - toxicity
Benzodiazepines - administration & dosage
Chromatography, Liquid
Designer Drugs - toxicity
Humans
Male
Middle Aged
Narcotics - blood
Substance-Related Disorders - mortality
Sweden
Tandem Mass Spectrometry
Young Adult
Abstract
AH-7921 (3,4-dichloro-N-[(1-dimethylamino)cyclohexylmethyl]benzamide) is a designer opioid with ~80% of morphine's µ-agonist activity. Over a 6-month period, we encountered nine deaths where AH-7921 was involved and detected in blood from the deceased. Shortly after the last death, on August 1 2013, AH-7921 was scheduled as a narcotic and largely disappeared from the illicit market in Sweden. AH-7921 was measured by a selective liquid chromatography-MS-MS method and the concentrations of AH-7921 ranged from 0.03 to 0.99 µg/g blood. Six of our cases had other drugs of abuse on board and most had other medications such as benzodiazepines, antidepressants and analgesics. However, the other medicinal drugs encountered were present in postmortem therapeutic concentrations and unlikely to have contributed to death. In addition to the parent compound, we identified six possible metabolites where two N-demethylated dominated and four mono-hydroxylated were found in trace amounts in the blood. In conclusion, deaths with AH-7921 seem to occur both at low and high concentrations, probably a result of different tolerance to the drug. Hence, it is reasonable to assume that no sharp dividing line exists between lethal and non-lethal concentrations. Further, poly-drug use did not seem to be a major contributing factor for the fatal outcome.
PubMed ID
25217553 View in PubMed
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XLR-11 and UR-144 in Washington state and state of Alaska driving cases.

https://arctichealth.org/en/permalink/ahliterature263563
Source
J Anal Toxicol. 2014 Oct;38(8):563-8
Publication Type
Article
Date
Oct-2014
Author
Asa Louis
Brianna L Peterson
Fiona J Couper
Source
J Anal Toxicol. 2014 Oct;38(8):563-8
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alaska
Automobile Driving
Cannabinoids - blood - standards
Dose-Response Relationship, Drug
Female
Humans
Indoles - blood - standards
Male
Street Drugs - blood
Substance Abuse Detection - methods
Washington
Young Adult
Abstract
The case reports for 18 driving cases positive for the synthetic cannabinoid substances XLR-11 and/or UR-144 are discussed. Eleven of these cases had drug recognition expert evaluations performed. Slurred speech, lack of convergence and body and eyelid tremors were the most consistently noted interview characteristic. Pulse and blood pressure of the subjects were within the expected range. Most of the drivers contacted demonstrated poor driving; however, their performance on the standardized field sobriety tests yielded inconsistent diagnostic information. All cases were negative for other commonly detected drugs that affect the central nervous system, although one case was additionally positive for other synthetic cannabinoids. Of the studied cases, six were positive for only UR-144, whereas eight contained only XLR-11. Four cases were found to have both.
PubMed ID
25217547 View in PubMed
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Effect of body condition on tissue distribution of perfluoroalkyl substances (PFASs) in Arctic fox (Vulpes lagopus).

https://arctichealth.org/en/permalink/ahliterature263564
Source
Environ Sci Technol. 2014 Oct 7;48(19):11654-61
Publication Type
Article
Date
Oct-7-2014
Author
Camilla Bakken Aas
Eva Fuglei
Dorte Herzke
Nigel G Yoccoz
Heli Routti
Source
Environ Sci Technol. 2014 Oct 7;48(19):11654-61
Date
Oct-7-2014
Language
English
Publication Type
Article
Keywords
Adipose Tissue - drug effects
Alkanesulfonic Acids - pharmacokinetics
Animals
Arctic Regions
Body Composition
Carbon Isotopes - analysis
Environmental Pollutants - pharmacokinetics
Fluorocarbons - pharmacokinetics
Foxes
Kidney - drug effects
Limit of Detection
Liver - drug effects
Muscles - drug effects
Nitrogen Isotopes - analysis
Svalbard
Tissue Distribution
Abstract
Arctic animals undergo large seasonal fluctuations in body weight. The effect of body condition on the distribution and composition of 16 perfluoroalkyl substances (PFASs) was investigated in liver, blood, kidney, adipose tissue, and muscle of Arctic foxes (Vulpes lagopus) from Svalbard (n = 18, age 1-3 years). PFAS concentrations were generally highest in liver, followed by blood and kidney, while lowest concentrations were found in adipose tissue and muscle. Concentrations of summed perfluorocarboxylic acids and perfluoroalkyl sulfonates were five and seven times higher, respectively, in adipose tissue of lean compared to fat foxes. In addition, perfluorodecanoate (PFDA) and perfluoroheptanesulfonate (PFHpS) concentrations in liver, kidney, and blood, and, perfluorononanoate (PFNA) in liver and blood, were twice as high in the lean compared to the fat foxes. The ratio between perfluorooctane sulfonamide (FOSA) and its metabolite perfluorooctanesulfonate (PFOS) was lowest in liver, muscle, and kidney, while significantly higher proportions of FOSA were found in adipose tissue and blood. The results of the present study suggest that toxic potential of exposure to PFAS among other pollutants in Arctic mammals may increase during seasonal emaciation. The results also suggest that body condition should be taken into account when assessing temporal trends of PFASs.
Notes
Erratum In: Environ Sci Technol. 2014 Nov 18;48(22):13558
PubMed ID
25215880 View in PubMed
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The impact of non-responders on health and lifestyle outcomes in an intervention study.

https://arctichealth.org/en/permalink/ahliterature263565
Source
BMC Res Notes. 2014;7:632
Publication Type
Article
Date
2014
Author
Elsebeth Hansen
Kirsten Fonager
Kirsten S Freund
Jørgen Lous
Source
BMC Res Notes. 2014;7:632
Date
2014
Language
English
Publication Type
Article
Keywords
Adult
Denmark
Female
General practice
Health Knowledge, Attitudes, Practice
Humans
Logistic Models
Male
Patient compliance
Preventive Health Services - methods
Questionnaires
Referral and Consultation
Reminder Systems
Risk Reduction Behavior
Selection Bias
Sex Factors
Telephone
Time Factors
Treatment Outcome
Vulnerable Populations - psychology
Young Adult
Abstract
A randomized intervention study, "Preventive consultations for 20- to 40-year-old young adults", investigated whether preventive consultations with a general practitioner could help young adults with multiple psychosocial and lifestyle problems to change health behavior. To optimize the response rate of questionnaires at 1 year post-intervention, the non-responders were reminded by telephone. The aim of this study was to examine potential selection bias induced by non-response by comparing responder and non-responder populations at baseline, and to examine the impact on outcomes by comparing initial respondents to respondents after telephone reminding.
Non-responders were compared with primary responders using logistic regression models that included socio-demographic factors, health-related factors, and variables related to the intervention study. In order to describe the impact of including responders after telephone reminding on the intervention's effect on different health, resource, and lifestyle outcomes, we compared results in models including and excluding responders after telephone reminding.
Telephone contact raised the response by 10% from 316 (64%) to 364 (74%) among young adults with multiple problems. Being male was the only factor that significantly predicted non-response in the model after adjustment for other variables. The responders after telephone reminding tended to improve health and lifestyle more than the primary responders, but not significantly so. Although the additional responses did not change the estimates of the 1-year effect on health and lifestyle changes, it contributed to increased precision of the results.
Even though the population of primary non-responders had to some degree a different composition than the primary responders, inclusion of responders after telephone reminding did not significantly change the estimates for effect at the 1-year follow-up; however, the additional responses increased the precision of the estimates.
ClinicalTrials.gov: NCT01231256.
Notes
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PubMed ID
25213806 View in PubMed
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Evolution and origin of sympatric shallow-water morphotypes of Lake Trout, Salvelinus namaycush, in Canada's Great Bear Lake.

https://arctichealth.org/en/permalink/ahliterature263566
Source
Heredity (Edinb). 2015 Jan;114(1):94-106
Publication Type
Article
Date
Jan-2015
Author
L N Harris
L. Chavarie
R. Bajno
K L Howland
S H Wiley
W M Tonn
E B Taylor
Source
Heredity (Edinb). 2015 Jan;114(1):94-106
Date
Jan-2015
Language
English
Publication Type
Article
Keywords
Animals
Biological Evolution
DNA, Mitochondrial - genetics
Ecotype
Fresh Water
Genetic Variation
Genetics, Population
Lakes
Linkage Disequilibrium
Microsatellite Repeats
Models, Genetic
Northwest Territories
Phenotype
Sequence Analysis, DNA
Sympatry
Trout - anatomy & histology - genetics
Abstract
Range expansion in north-temperate fishes subsequent to the retreat of the Wisconsinan glaciers has resulted in the rapid colonization of previously unexploited, heterogeneous habitats and, in many situations, secondary contact among conspecific lineages that were once previously isolated. Such ecological opportunity coupled with reduced competition likely promoted morphological and genetic differentiation within and among post-glacial fish populations. Discrete morphological forms existing in sympatry, for example, have now been described in many species, yet few studies have directly assessed the association between morphological and genetic variation. Morphotypes of Lake Trout, Salvelinus namaycush, are found in several large-lake systems including Great Bear Lake (GBL), Northwest Territories, Canada, where several shallow-water forms are known. Here, we assess microsatellite and mitochondrial DNA variation among four morphotypes of Lake Trout from the five distinct arms of GBL, and also from locations outside of this system to evaluate several hypotheses concerning the evolution of morphological variation in this species. Our data indicate that morphotypes of Lake Trout from GBL are genetically differentiated from one another, yet the morphotypes are still genetically more similar to one another compared with populations from outside of this system. Furthermore, our data suggest that Lake Trout colonized GBL following dispersal from a single glacial refugium (the Mississippian) and support an intra-lake model of divergence. Overall, our study provides insights into the origins of morphological and genetic variation in post-glacial populations of fishes and provides benchmarks important for monitoring Lake Trout biodiversity in a region thought to be disproportionately susceptible to impacts from climate change.
PubMed ID
25204304 View in PubMed
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Co-digestion of cultivated microalgae and sewage sludge from municipal waste water treatment.

https://arctichealth.org/en/permalink/ahliterature263567
Source
Bioresour Technol. 2014 Nov;171:203-10
Publication Type
Article
Date
Nov-2014
Author
Jesper Olsson
Xin Mei Feng
Johnny Ascue
Francesco G Gentili
M A Shabiimam
Emma Nehrenheim
Eva Thorin
Source
Bioresour Technol. 2014 Nov;171:203-10
Date
Nov-2014
Language
English
Publication Type
Article
Keywords
Anaerobiosis
Biofuels
Lakes - microbiology
Methane - biosynthesis
Microalgae - metabolism
Sewage - microbiology
Sweden
Temperature
Waste Disposal, Fluid - methods
Waste Water - microbiology
Abstract
In this study two wet microalgae cultures and one dried microalgae culture were co-digested in different proportions with sewage sludge in mesophilic and thermophilic conditions. The aim was to evaluate if the co-digestion could lead to an increased efficiency of methane production compared to digestion of sewage sludge alone. The results showed that co-digestion with both wet and dried microalgae, in certain proportions, increased the biochemical methane potential (BMP) compared with digestion of sewage sludge alone in mesophilic conditions. The BMP was significantly higher than the calculated BMP in many of the mixtures. This synergetic effect was statistically significant in a mixture containing 63% (w/w VS based) undigested sewage sludge and 37% (w/w VS based) wet algae slurry, which produced 23% more methane than observed with undigested sewage sludge alone. The trend was that thermophilic co-digestion of microalgae and undigested sewage sludge did not give the same synergy.
PubMed ID
25203227 View in PubMed
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300254 records – page 1 of 30026.