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Beliefs about medications: measurement and relationship to adherence in patients with severe mental disorders.

https://arctichealth.org/en/permalink/ahliterature154404
Source
Acta Psychiatr Scand. 2009 Jan;119(1):78-84
Publication Type
Article
Date
Jan-2009
Author
H. Jónsdóttir
S. Friis
R. Horne
K I Pettersen
A. Reikvam
O A Andreassen
Author Affiliation
Division of Psychiatry, Ulleval University Hospital & Institute of Psychiatry, University of Oslo, Oslo, Norway. halldora.jonsdottir@medisin.uio.no
Source
Acta Psychiatr Scand. 2009 Jan;119(1):78-84
Date
Jan-2009
Language
English
Publication Type
Article
Keywords
Adult
Anticonvulsants - adverse effects - therapeutic use
Antidepressive Agents - adverse effects - therapeutic use
Antipsychotic Agents - adverse effects - therapeutic use
Bipolar Disorder - drug therapy - psychology
Cross-Sectional Studies
Culture
Female
Humans
Lithium Carbonate - adverse effects - therapeutic use
Male
Norway
Patient Compliance - psychology
Psychometrics
Psychotic Disorders - drug therapy - psychology
Psychotropic Drugs - adverse effects - therapeutic use
Questionnaires
Schizophrenia - drug therapy
Schizophrenic Psychology
Abstract
To determine if the Beliefs about Medicines Questionnaire (BMQ) has satisfactory psychometric properties in patients with severe mental disorders and if their scores differ from those of patients with severe medical disorders. To investigate if the scores are related to medication adherence.
Two hundred and eighty psychiatric patients completed the BMQ and reported how much of their medication they had taken the past week. Serum concentrations of medications were analyzed. BMQ scores were compared with those of patients with chronic medical disorders.
Cronbach's alpha was satisfactory for all subscales. The psychiatric group scored lower on the necessity of taking medication than the medical group. Non-adherent patients felt medication to be less necessary and were more concerned about it than adherent patients. The necessity subscale predicted adherence fairly well.
The BMQ has satisfactory psychometric properties for use in patients with severe mental disorders. The constructs measured by the BMQ are related to adherence in these patients.
PubMed ID
18983630 View in PubMed
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Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.

https://arctichealth.org/en/permalink/ahliterature154634
Source
Mol Psychiatry. 2010 May;15(5):463-72
Publication Type
Article
Date
May-2010
Author
S. Le Hellard
T W Mühleisen
S. Djurovic
J. Fernø
Z. Ouriaghi
M. Mattheisen
C. Vasilescu
M B Raeder
T. Hansen
J. Strohmaier
A. Georgi
F F Brockschmidt
I. Melle
I. Nenadic
H. Sauer
M. Rietschel
M M Nöthen
T. Werge
O A Andreassen
S. Cichon
V M Steen
Author Affiliation
Department of Clinical Medicine, Bergen Mental Health Research Center, University of Bergen, Bergen, Norway. stephanie.le.hellard@helse-bergen.no
Source
Mol Psychiatry. 2010 May;15(5):463-72
Date
May-2010
Language
English
Publication Type
Article
Keywords
Adult
Antipsychotic Agents - therapeutic use
Case-Control Studies
Chromosomes, Human, Pair 17 - genetics
Chromosomes, Human, Pair 22 - genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Germany
Humans
Lipogenesis - drug effects - genetics
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide - genetics
Scandinavia
Schizophrenia - drug therapy - genetics
Sterol Regulatory Element Binding Protein 1 - genetics
Sterol Regulatory Element Binding Protein 2 - genetics
Abstract
Several studies have reported structural brain abnormalities, decreased myelination and oligodendrocyte dysfunction in schizophrenia. In the central nervous system, glia-derived de novo synthesized cholesterol is essential for both myelination and synaptogenesis. Previously, we demonstrated in glial cell lines that antipsychotic drugs induce the expression of genes involved in cholesterol and fatty acids biosynthesis through activation of the sterol regulatory element binding protein (SREBP) transcription factors, encoded by the sterol regulatory element binding transcription factor 1 (SREBF1) and sterol regulatory element binding transcription factor 2 (SREBF2) genes. Considering the importance of these factors in the lipid biosynthesis and their possible involvement in antipsychotic drug effects, we hypothesized that genetic variants of SREBF1 and/or SREBF2 could affect schizophrenia susceptibility. We therefore conducted a HapMap-based association study in a large German sample, and identified association between schizophrenia and five markers in SREBF1 and five markers in SREBF2. Follow-up studies in two independent samples of Danish and Norwegian origin (part of the Scandinavian collaboration of psychiatric etiology study, SCOPE) replicated the association for the five SREBF1 markers and for two markers in SREBF2. A combined analysis of all samples resulted in highly significant genotypic P-values of 9 x 10(-4) for SREBF1 (rs11868035, odd ration (OR)=1.26, 95% confidence interval (CI) (1.09-1.45)) and 4 x 10(-5) for SREBF2 (rs1057217, OR=1.39, 95% CI (1.19-1.63)). This finding strengthens the hypothesis that SREBP-controlled cholesterol biosynthesis is involved in the etiology of schizophrenia.
PubMed ID
18936756 View in PubMed
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Childhood trauma mediates the association between ethnic minority status and more severe hallucinations in psychotic disorder.

https://arctichealth.org/en/permalink/ahliterature265239
Source
Psychol Med. 2015 Jan;45(1):133-42
Publication Type
Article
Date
Jan-2015
Author
A O Berg
M. Aas
S. Larsson
M. Nerhus
E. Hauff
O A Andreassen
I. Melle
Source
Psychol Med. 2015 Jan;45(1):133-42
Date
Jan-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Adult Survivors of Child Abuse - psychology
Africa - ethnology
Aged
Asia - ethnology
Cross-Sectional Studies
Ethnic groups - psychology - statistics & numerical data
Female
Hallucinations - diagnosis - epidemiology - etiology
Humans
Male
Middle Aged
Minority Groups - psychology - statistics & numerical data
Multivariate Analysis
Norway - epidemiology
Psychiatric Status Rating Scales
Psychotic Disorders - diagnosis - epidemiology - etiology
Risk factors
Self Report
Young Adult
Abstract
Ethnic minority status and childhood trauma are established risk factors for psychotic disorders. Both are found to be associated with increased level of positive symptoms, in particular auditory hallucinations. Our main aim was to investigate the experience and effect of childhood trauma in patients with psychosis from ethnic minorities, hypothesizing that they would report more childhood trauma than the majority and that this would be associated with more current and lifetime hallucinations.
In this cross-sectional study we included 454 patients with a SCID-I DSM-IV diagnosis of non-affective or affective psychotic disorder. Current hallucinations were measured with the Positive and Negative Syndrome Scale (P3; Hallucinatory Behaviour). Lifetime hallucinations were assessed with the SCID-I items: auditory hallucinations, voices commenting and two or more voices conversing. Childhood trauma was assessed with the Childhood Trauma Questionnaire, self-report version.
Patients from ethnic minority groups (n = 69) reported significantly more childhood trauma, specifically physical abuse/neglect, and sexual abuse. They had significantly more current hallucinatory behaviour and lifetime symptoms of hearing two or more voices conversing. Regression analyses revealed that the presence of childhood trauma mediated the association between ethnic minorities and hallucinations.
More childhood trauma in ethnic minorities with psychosis may partially explain findings of more positive symptoms, especially hallucinations, in this group. The association between childhood trauma and these first-rank symptoms may in part explain this group's higher risk of being diagnosed with a schizophrenia-spectrum diagnosis. The findings show the importance of childhood trauma in symptom development in psychosis.
PubMed ID
25065296 View in PubMed
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Sleep problems in bipolar disorders: more than just insomnia.

https://arctichealth.org/en/permalink/ahliterature279446
Source
Acta Psychiatr Scand. 2016 May;133(5):368-77
Publication Type
Article
Date
May-2016
Author
M K Steinan
J. Scott
T V Lagerberg
I. Melle
O A Andreassen
A E Vaaler
G. Morken
Source
Acta Psychiatr Scand. 2016 May;133(5):368-77
Date
May-2016
Language
English
Publication Type
Article
Keywords
Adult
Bipolar Disorder - epidemiology
Comorbidity
Cross-Sectional Studies
Disorders of Excessive Somnolence - epidemiology
Female
Humans
Male
Middle Aged
Norway - epidemiology
Sleep Initiation and Maintenance Disorders - epidemiology
Abstract
Sleep problems in bipolar disorder (BD) are common, but reported rates vary from 10% to 80%, depending on definitions, methodologies and management of potential confounding factors. This multicenter study seeks to address these issues and also compares BD cases with Hypersomnia as well as the more commonly investigated Insomnia and No Sleep Problem groups.
A cross-sectional comparison of sleep profiles in 563 BD I and II individuals who participated in a structured assessment of demographic, clinical, illness history and treatment variables.
Over 40% cases met criteria for Insomnia and 29% for Hypersomnia. In univariate analysis, Insomnia was associated with BD II depression whilst Hypersomnia was associated with BD I depression or euthymia. After controlling for confounders and covariates, it was demonstrated that Hypersomnia cases were significantly more likely to be younger, have BD I and be prescribed antidepressants whilst Insomnia cases had longer illness durations and were more likely to be prescribed benzodiazepines and hypnotics.
Whilst Insomnia symptoms are common in BD, Hypersomnia is a significant, frequently underexplored problem. Detailed analyses of large representative clinical samples are critical to extending our knowledge of differences between subgroups defined by sleep profile.
PubMed ID
26590799 View in PubMed
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General psychopathology is more important for executive functioning than diagnosis.

https://arctichealth.org/en/permalink/ahliterature45737
Source
Acta Psychiatr Scand. 2005 Jan;111(1):22-8
Publication Type
Article
Date
Jan-2005
Author
K I Stordal
A. Mykletun
A. Asbjørnsen
J. Egeland
N I Landrø
A. Roness
B R Rund
K S Sundet
A J Lundervold
A. Lund
Author Affiliation
Department of Psychiatry, University of Bergen, Bergen, Norway. kristen.irene.stordal@helse-bergen.no
Source
Acta Psychiatr Scand. 2005 Jan;111(1):22-8
Date
Jan-2005
Language
English
Publication Type
Article
Keywords
Adult
Comparative Study
Depressive Disorder, Major - diagnosis - psychology
Female
Humans
Male
Middle Aged
Neuropsychological Tests - statistics & numerical data
Norway
Problem Solving
Psychiatric Status Rating Scales - statistics & numerical data
Psychometrics - statistics & numerical data
Psychopathology
Reference Values
Reproducibility of Results
Research Support, Non-U.S. Gov't
Schizophrenia - diagnosis
Schizophrenic Psychology
Statistics
Abstract
OBJECTIVE: Impaired executive functioning (EF) has often been reported in patients with major depression or schizophrenia. We hypothesize that the variance in EF is more affected by level of general psychopathology than by diagnosis. METHOD: Forty-three patients with major depression and 47 with schizophrenia were included. EF was measured with Wisconsin Card Sorting Test, Stroop Colour Word Test, Paced Auditory Serial Addition Test, Digits Backwards and Controlled Oral Word Association Test. The level of general psychopathology was measured with Brief Psychiatric Rating Scale - Expanded and Positive and Negative Syndrome Scale, the General psychopathology subscale. RESULTS: The level of general psychopathology predicted more of the variance in EF than diagnosis. In multivariate analyses, the effect of general psychopathology on EF was more robust for adjustment for diagnosis than vice versa. CONCLUSION: Future research on cognitive functioning in psychiatric patients should include level of general psychopathology to avoid overemphasising effects of diagnoses.
PubMed ID
15636590 View in PubMed
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Early identification of non-remission in first-episode psychosis in a two-year outcome study.

https://arctichealth.org/en/permalink/ahliterature141450
Source
Acta Psychiatr Scand. 2010 Nov;122(5):375-83
Publication Type
Article
Date
Nov-2010
Author
Erik Simonsen
S. Friis
S. Opjordsmoen
E L Mortensen
U. Haahr
I. Melle
I. Joa
J O Johannessen
T K Larsen
J I Røssberg
B R Rund
P. Vaglum
T H McGlashan
Author Affiliation
Psychiatric Research Unit, Zealand Region Psychiatry Roskilde, Roskilde University and University of Copenhagen, Copenhagen, Denmark. es@regionsjaelland.dk
Source
Acta Psychiatr Scand. 2010 Nov;122(5):375-83
Date
Nov-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Aged
Chi-Square Distribution
Denmark - epidemiology
Female
Humans
Logistic Models
Male
Marital status
Middle Aged
Norway - epidemiology
Psychotherapy
Psychotic Disorders - diagnosis - epidemiology - psychology - therapy
Remission Induction
Sex Factors
Social Adjustment
Statistics, nonparametric
Substance-Related Disorders - psychology
Treatment Outcome
Young Adult
Abstract
To identify predictors of non-remission in first-episode, non-affective psychosis.
During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years.
One hundred and twenty-nine patients (43%) remained psychotic at 3 months and 48 patients (16.4%) remained psychotic over 2 years. When we compared premorbid and baseline data for the three groups, the non-remitted (n = 48), remitted for
Notes
Comment In: Acta Psychiatr Scand. 2011 Jun;123(6):49421219270
PubMed ID
20722632 View in PubMed
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Costs of services for schizophrenic patients in Norway.

https://arctichealth.org/en/permalink/ahliterature72405
Source
Acta Psychiatr Scand. 1999 Feb;99(2):120-5
Publication Type
Article
Date
Feb-1999
Author
B R Rund
T. Ruud
Author Affiliation
Institute of Psychology, University of Oslo, Norway.
Source
Acta Psychiatr Scand. 1999 Feb;99(2):120-5
Date
Feb-1999
Language
English
Publication Type
Article
Keywords
Acute Disease
Adult
Female
Health Care Costs
Humans
Male
Norway
Research Support, Non-U.S. Gov't
Schizophrenia - economics - therapy
Schizophrenic Psychology
Abstract
Estimates of the direct costs of mental health services for patients with schizophrenia are made from a registration of all patients seen during a period of 4 weeks in all treatment units serving 6 catchment areas. The estimates were based on unit costs. The total direct costs of mental health services for schizophrenic patients in Norway were estimated to be NOK 1158 million (US$ 164 million). In total, 74.3% of the costs are for long-term in-patient care, 19.7% are for acute and intermediate length in-patient care, and 6.0% are for out-patient and day care. The average costs of schizophrenic patients with a GAF score of 1-20 are almost twice those of patients with a GAF score of 21-40, and more than three times those of patients with a GAF score of 41-60.
PubMed ID
10082187 View in PubMed
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The effect of gender on emotion perception in schizophrenia and bipolar disorder.

https://arctichealth.org/en/permalink/ahliterature161536
Source
Acta Psychiatr Scand. 2007 Oct;116(4):263-70
Publication Type
Article
Date
Oct-2007
Author
A. Vaskinn
K. Sundet
S. Friis
C. Simonsen
A B Birkenaes
J A Engh
H. Jónsdóttir
P A Ringen
S. Opjordsmoen
O A Andreassen
Author Affiliation
Institute of Psychiatry, University of Oslo, Norway. anja.vaskin@medisin.uio.no
Source
Acta Psychiatr Scand. 2007 Oct;116(4):263-70
Date
Oct-2007
Language
English
Publication Type
Article
Keywords
Adult
Auditory Perceptual Disorders - diagnosis - psychology
Bipolar Disorder - diagnosis - psychology
Concept Formation
Emotions
Facial Expression
Female
Humans
Male
Norway
Pattern Recognition, Visual
Personal Construct Theory
Schizophrenia - diagnosis
Schizophrenic Language
Schizophrenic Psychology
Sex Factors
Speech Acoustics
Speech Perception
Abstract
Impaired emotion perception is documented for schizophrenia, but findings have been mixed for bipolar disorder. In healthy samples females perform better than males. This study compared emotion perception in schizophrenia and bipolar disorder and investigated the effects of gender.
Visual (facial pictures) and auditory (sentences) emotional stimuli were presented for identification and discrimination in groups of participants with schizophrenia, bipolar disorder and healthy controls.
Visual emotion perception was unimpaired in both clinical groups, but the schizophrenia sample showed reduced auditory emotion perception. Healthy males and male schizophrenia subjects performed worse than their female counterparts, whereas there were no gender differences within the bipolar group.
A disease-specific auditory emotion processing deficit was confirmed in schizophrenia, especially for males. Participants with bipolar disorder performed unimpaired.
PubMed ID
17803756 View in PubMed
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No progressive brain changes during a 1-year follow-up of patients with first-episode psychosis.

https://arctichealth.org/en/permalink/ahliterature276617
Source
Psychol Med. 2016 Feb;46(3):589-98
Publication Type
Article
Date
Feb-2016
Author
U K Haukvik
C B Hartberg
S. Nerland
K N Jørgensen
E H Lange
C. Simonsen
R. Nesvåg
A M Dale
O A Andreassen
I. Melle
I. Agartz
Source
Psychol Med. 2016 Feb;46(3):589-98
Date
Feb-2016
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Antipsychotic Agents - therapeutic use
Bipolar Disorder - drug therapy - pathology
Case-Control Studies
Cerebral Cortex - pathology
Disease Progression
Female
Follow-Up Studies
Humans
Linear Models
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Norway
Psychotic Disorders - drug therapy - pathology
Schizophrenia - drug therapy - pathology
Young Adult
Abstract
First-episode psychosis (FEP) patients show structural brain abnormalities. Whether the changes are progressive or not remain under debate, and the results from longitudinal magnetic resonance imaging (MRI) studies are mixed. We investigated if FEP patients showed a different pattern of regional brain structural change over a 1-year period compared with healthy controls, and if putative changes correlated with clinical characteristics and outcome.
MRIs of 79 FEP patients [SCID-I-verified diagnoses: schizophrenia, psychotic bipolar disorder, or other psychoses, mean age 27.6 (s.d. = 7.7) years, 66% male] and 82 healthy controls [age 29.3 (s.d. = 7.2) years, 66% male] were acquired from the same 1.5 T scanner at baseline and 1-year follow-up as part of the Thematically Organized Psychosis (TOP) study, Oslo, Norway. Scans were automatically processed with the longitudinal stream in FreeSurfer that creates an unbiased within-subject template image. General linear models were used to analyse longitudinal change in a wide range of subcortical volumes and detailed thickness and surface area estimates across the entire cortex, and associations with clinical characteristics.
FEP patients and controls did not differ significantly in annual percentage change in cortical thickness or area in any cortical region, or in any of the subcortical structures after adjustment for multiple comparisons. Within the FEP group, duration of untreated psychosis, age at illness onset, antipsychotic medication use and remission at follow-up were not related to longitudinal brain change.
We found no significant longitudinal brain changes over a 1-year period in FEP patients. Our results do not support early progressive brain changes in psychotic disorders.
PubMed ID
26526001 View in PubMed
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Assessment of social anxiety in first episode psychosis using the Liebowitz Social Anxiety scale as a self-report measure.

https://arctichealth.org/en/permalink/ahliterature139685
Source
Eur Psychiatry. 2011 Mar;26(2):115-21
Publication Type
Article
Date
Mar-2011
Author
K L Romm
J I Rossberg
A O Berg
C F Hansen
O A Andreassen
I. Melle
Author Affiliation
Psychosis Research Unit, Division of Mental Health and Addiction, Oslo University Hospital, 0407 Oslo, Norway. k.l.romm@medisin.uio.no
Source
Eur Psychiatry. 2011 Mar;26(2):115-21
Date
Mar-2011
Language
English
Publication Type
Article
Keywords
Adult
Aged
Anxiety Disorders - classification - diagnosis - psychology
Factor Analysis, Statistical
Humans
Middle Aged
Norway
Phobic Disorders - classification - diagnosis - psychology
Psychometrics
Reproducibility of Results
Self Concept
Self Report - standards
Social Environment
Social Isolation
Young Adult
Abstract
Social anxiety is a common problem in psychotic disorders. The Liebowitz Social Anxiety Scale, Self-Rating version (LSAS-SR) is a widely used instrument to capture different aspects of social anxiety, but its psychometric properties have not been tested in this patient group. The aims of the present study were to evaluate the psychometric properties of the LSAS-SR in patients with first episode psychosis, to investigate whether it differentiated between active and passive social withdrawal and to test which clinical factors contributed to current level of social anxiety.
A total of 144 first episode psychosis patients from the ongoing Thematically Organized Psychosis (TOP) study were included at the time of first treatment. Diagnoses were set according to the Structured Clinical Interview (SCID-1) for DSM-IV. A factor analysis was carried out and the relationship of social anxiety to psychotic and general symptomatology measured by the Positive and Negative Syndrome Scale (PANSS) was evaluated. Possible contributors to social anxiety were analyzed using multiple hierarchic regression analysis.
The factor analysis identified three subscales: public performance, social interaction and observation. All three subscales showed satisfactory psychometric properties, acceptable convergent and discriminate properties, and confirmed previous findings in social anxiety samples. Self-esteem explained a significant amount of the variance in social anxiety, even after adjusting for the effects of delusions, suspiciousness and depression.
The study shows that the LSAS-SR can be used in this patient group, that social anxiety is strongly related to both behavioral social avoidance and to self-esteem. The results support the use of this measure in assessment of social anxiety in both clinical settings and in research.
PubMed ID
21036553 View in PubMed
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15 records – page 1 of 2.