Sweden has been a pioneer in the treatment of haemophilia, with the first concentrate available in the 1950s. Treatment has improved over the years to its current state-of-the art. The aim of the current study was to evaluate the long-term outcome of haemophilia in terms of incidence, morbidity and mortality. Patients diagnosed with haemophilia A or B registered at the national haemophilia centres and/or the Patient Registry and born before 2009 and alive in 1968 were enrolled and linked to the Cause of Death-, Migration- and Medical Birth registries. Five age- and sex-matched controls were selected for each patient. A total of 1431 patients with haemophilia A or B were compared with 7150 controls. The 3-year moving average incidence rate per 100,000 population varied between 21 and 36. The hazard ratio for all-cause mortality compared with controls was 2.2, 95% CI: [1.8; 2.7], P
Infants born preterm account for a substantial part of neonatal morbidity, with acute respiratory disorders being a dominating clinical problem. Whereas focus in recent studies has been on extremely and very preterm infants, less is known about contemporary rates and risk factors for acute respiratory morbidity in moderately and late preterm infants. The objective of this population-based Swedish study was to establish rates for different acute respiratory diseases in moderately preterm infants, and to identify maternal, obstetric and neonatal risk factors for the two most common diagnoses, transient tachypnoea of the newborn (TTN) and respiratory distress syndrome (RDS).
The study included 4679 moderately preterm [gestational age (GA): 30 to 34 weeks], 15?036 late preterm infants (GA 35 to 36 weeks) and 451?479 term infants (GA: 37 to 41 weeks). All infants were born in 2004-2008.
In moderately preterm infants, risk factors for TTN in multivariable analyses were multiparity, caesarean section before and after onset of labour, male sex, Apgar score 4-6 at 5 min and lower GA. Risk factors for RDS were multiparity, caesarean section before and after onset of labour, male sex, Apgar score
Newborn weight may vary between ethnic groups, but it is not known if birthweight differences exist between term babies born to immigrant mothers compared with those born in their corresponding native countries.
We completed a systematic review of all birthweight curves published between 1980 and 2012, based on at least 100 singleton deliveries. We compared the 10th, 50th and 90th percentile birthweight values at 40 weeks gestation for male and female infants born in their native country vs. those infants born to mothers who had emigrated from their native country to Ontario, Canada. For the 50th percentile values, we also calculated a standardised pooled weighted difference and 95% confidence interval [CI] for both sexes. We also assessed whether birthweight differed over time, or if the differences varied by the Human Development Index (HDI) value for the native country.
A total of 31 studies from 21 different countries met the inclusion criteria, comprising 13?317?578 males and 12?859?119 females born at 40 weeks gestation. There was a small non-significant rise in reported birthweight percentile values between 1983 and 2006. Nearly all infants born to women in their native country had lower birthweights than those born to mothers who had emigrated from the same country to Canada at the 10th, 50th and 90th percentiles. Overall, the 50th percentile weights differed by 115 g [95% CI 74, 156] for males and 122 g [95% CI 95, 150] for females. As HDI or median birthweight increased, birthweight differences were less pronounced, but not significantly so.
Term birthweight percentiles are typically higher among term infants born to mother who immigrate to Canada than those of infants born in their respective native country.
The study was implemented in 2008-2010. The research base consisted of three rural areas of the Republic of Dagestan. The quality of dispensarization of children studied according the expertise of 912 records of child development. The expertise established a number of deficiencies. The three-year old children were observed irregularly in 46.9% of cases by district pediatricians and in 40.1% of cases by medical nurses. The examination was carried out untimely in 55.5% of cases and in incomplete scope in 79.2% of cases. It is established that in children morbidity based on appealability data remains at high level: 2609 per thousand at first year of life, 1923.9 per thousand at second year of life and 1638.4 per thousand at third year of life. The exhausted morbidity consisted 2978.7 per thousand. The recommendations and guidelines were formulated to enhance the quality of dispensarization and to decrease the morbidity of children of early age.
This paper demonstrates the efficacy of prophylactic measures among the children of a perinatal risk group. The effectiveness of preventive measures was estimated based on the model developed in the Children's Healthcare Centre, Reutov, Moscow region. It is concluded that the introduction of the proposed program in the practical work of other children's health centres would promote the solution of the debatable problem pertaining to the choice of optimal measures for the observation and treatment of the children under the age of 5-6 years based at the children's healthcare centres.
Recent evidence has demonstrated the prenatal initiation of childhood obesity as epidemiological studies and animal studies have illustrated the effect of the intrauterine milieu for subsequent development of childhood obesity. This study investigates the relationship between severe childhood obesity and the preceding in utero conditions expressed by birth weight and birth length, birth-weight-for-gestational-age and neonatal ponderal index in a Danish cohort of 1,171 severely obese children (median age 11.48 years, range 3.13 to 17.98 years) with a mean body mass index-standard derivation score (BMI-SDS) of +2.96 (range +1.65 to +9.72) treated in our national referral centre. In a linear general regression model adjusted for socioeconomic status and breastfeeding duration, a significant linear correlation between BMI-SDS at time of enrolment and both birth weight (p, 3.8?×?10(-6)) and birth length (p, 6.1?×?10(-4)), birth-weight-for-gestational-age (p, 4.3?×?10(-7)) and the neonatal ponderal index (p, 0.02) was demonstrated. Duration of breastfeeding, however, was not found to be significant for either the BMI-SDS/BW or the BMI-SDS/BL correlation.
These results indicate that the prenatal period can be considered as a potential window of opportunity for prevention of childhood overweight and obesity and anthropological measurements may in theory be used to help identify neonates at high risk for developing childhood obesity.
For the past two decades it has been common practice in Denmark to withhold or withdraw medical care from neonates born before 28 weeks of gestation if they have poor survival chances or risk of future complications (poor quality of life). This practice is neither supported by the Danish Health Law, a law which furthermore does not include a consideration to quality of life, nor fully recognized as neonatal euthanasia. This is unacceptable as it results in a lack of proper guidelines relating to moral aspects and a failure to understand the full moral impact of neonatal euthanasia.
This paper describes the design of the fourth phase of the Canadian total diet study, conducted for the period 1992-1999. During this phase, complete sets of foods were purchased from eight cities (from one of them twice). For each of the sets, individual foods were prepared as for consumption into about 140 different food composites at Kemptville College, homogenised and bottled. Water from Kemptville, Ontario, was used for the preparation of the foods. The composites were stored frozen at -20?C and then analysed in the Food Research Division for chlorinated dioxins and dibenzofurans, pesticides, PCBs and trace elements. The analytical results were combined with average food consumption values for different age/sex groups, and dietary intakes were calculated. The design of the total diet study provided information to achieve the following goals: (a) background concentrations of the chemicals in the 140 different food composites, (b) average dietary intakes of the chemicals by the population and by different age/sex groups, (c) percent contribution of individual foods and food groups to the dietary intakes, (d) identification of individual contaminated foods and (e) identification of trends in human exposure with time.
282 (564 eyes) premature infants born at mean 27 +/- 2,5 weeks of gestation with birth weight 914+/- 247g were enrolled in the study. Comparative study showed preventive treatment with histochrome in infants with risk of retinopathy of prematurity (RP) to decrease the incidence of RP compared to infants treated with emoxipine and no antioxidant therapy. Incidence of RP in infants preventively treated with combination antioxidant agents (dicynon and emoxipine) was significantly lower compared to the group without preventive antioxidant treatment. Use of histochrome in treatment of RP via periocular injections and forced instillations promoted more favorable outcome of the disease.