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The 1,600-year-old skeleton of a middle-age Eskimo woman found near Homer in 1974.

https://arctichealth.org/en/permalink/ahliterature2
Source
Alaska. 49(2):27.
Publication Type
Article
Date
1983
Source
Alaska. 49(2):27.
Date
1983
Geographic Location
Multi-National
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Cancer
Fractures
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 191.
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1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents.

https://arctichealth.org/en/permalink/ahliterature273208
Source
PLoS One. 2015;10(8):e0135018
Publication Type
Article
Date
2015
Author
Cilius Esmann Fonvig
Elizaveta Chabanova
Ehm Astrid Andersson
Johanne Dam Ohrt
Oluf Pedersen
Torben Hansen
Henrik S Thomsen
Jens-Christian Holm
Source
PLoS One. 2015;10(8):e0135018
Date
2015
Language
English
Publication Type
Article
Keywords
Adolescent
Anthropometry
Blood Glucose - analysis
Blood pressure
Body mass index
Body Weight
Cardiovascular Diseases - physiopathology
Child
Cross-Sectional Studies
Denmark
Dyslipidemias - blood
Fatty Liver - pathology
Female
Humans
Insulin - blood
Insulin Resistance
Intra-Abdominal Fat - pathology
Linear Models
Lipids - blood
Liver - metabolism - pathology
Male
Muscles - pathology
Overweight
Pediatric Obesity - blood - pathology
Proton Magnetic Resonance Spectroscopy
Puberty
Sex Factors
Subcutaneous Fat - pathology
Abstract
This cross sectional study aims to investigate the associations between ectopic lipid accumulation in liver and skeletal muscle and biochemical measures, estimates of insulin resistance, anthropometry, and blood pressure in lean and overweight/obese children.
Fasting plasma glucose, serum lipids, serum insulin, and expressions of insulin resistance, anthropometry, blood pressure, and magnetic resonance spectroscopy of liver and muscle fat were obtained in 327 Danish children and adolescents aged 8-18 years.
In 287 overweight/obese children, the prevalences of hepatic and muscular steatosis were 31% and 68%, respectively, whereas the prevalences in 40 lean children were 3% and 10%, respectively. A multiple regression analysis adjusted for age, sex, body mass index z-score (BMI SDS), and pubertal development showed that the OR of exhibiting dyslipidemia was 4.2 (95%CI: [1.8; 10.2], p = 0.0009) when hepatic steatosis was present. Comparing the simultaneous presence of hepatic and muscular steatosis with no presence of steatosis, the OR of exhibiting dyslipidemia was 5.8 (95%CI: [2.0; 18.6], p = 0.002). No significant associations between muscle fat and dyslipidemia, impaired fasting glucose, or blood pressure were observed. Liver and muscle fat, adjusted for age, sex, BMI SDS, and pubertal development, associated to BMI SDS and glycosylated hemoglobin, while only liver fat associated to visceral and subcutaneous adipose tissue and intramyocellular lipid associated inversely to high density lipoprotein cholesterol.
Hepatic steatosis is associated with dyslipidemia and liver and muscle fat depositions are linked to obesity-related metabolic dysfunctions, especially glycosylated hemoglobin, in children and adolescents, which suggest an increased cardiovascular disease risk.
Notes
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Cites: Diabetes Care. 2007 Jan;30(1):89-9417192339
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Cites: J Clin Res Pediatr Endocrinol. 2010;2(3):100-621274322
Cites: Diabetologia. 2011 Apr;54(4):869-7521181394
Cites: Abdom Imaging. 2013 Apr;38(2):315-922736224
PubMed ID
26252778 View in PubMed
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(1) H NMR study and multivariate data analysis of reindeer skin tanning methods.

https://arctichealth.org/en/permalink/ahliterature276247
Source
Magn Reson Chem. 2016 Sep 21;
Publication Type
Article
Date
Sep-21-2016
Author
Lizheng Zhu
Andrew J Ilott
Eleonora Del Federico
Cindie Kehlet
Torunn Klokkernes
Alexej Jerschow
Source
Magn Reson Chem. 2016 Sep 21;
Date
Sep-21-2016
Language
English
Publication Type
Article
Abstract
Reindeer skin clothing has been an essential component in the lives of indigenous people of the arctic and sub-arctic regions, keeping them warm during harsh winters. However, the skin processing technology, which often conveys the history and tradition of the indigenous group, has not been well documented. In this study, NMR spectra and relaxation behaviors of reindeer skin samples treated with a variety of vegetable tannin extracts, oils and fatty substances are studied and compared. With the assistance of principal component analysis (PCA), one can recognize patterns and identify groupings of differently treated samples. These methods could be important aids in efforts to conserve museum leather artifacts with unknown treatment methods and in the analysis of reindeer skin tanning processes.
PubMed ID
27654838 View in PubMed
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1 H NMR study and multivariate data analysis of reindeer skin tanning methods.

https://arctichealth.org/en/permalink/ahliterature291047
Source
Magn Reson Chem. 2017 Apr; 55(4):312-317
Publication Type
Journal Article
Date
Apr-2017
Author
Lizheng Zhu
Andrew J Ilott
Eleonora Del Federico
Cindie Kehlet
Torunn Klokkernes
Alexej Jerschow
Author Affiliation
Department of Chemistry, New York University, New York, NY, USA.
Source
Magn Reson Chem. 2017 Apr; 55(4):312-317
Date
Apr-2017
Language
English
Publication Type
Journal Article
Keywords
Animals
Humans
Magnetic Resonance Spectroscopy
Multivariate Analysis
Plant Extracts - chemistry
Reindeer
Seasons
Skin - chemistry
Tanning - methods
Tannins - chemistry
Vegetables - chemistry
Abstract
Reindeer skin clothing has been an essential component in the lives of indigenous people of the arctic and sub-arctic regions, keeping them warm during harsh winters. However, the skin processing technology, which often conveys the history and tradition of the indigenous group, has not been well documented. In this study, NMR spectra and relaxation behaviors of reindeer skin samples treated with a variety of vegetable tannin extracts, oils and fatty substances are studied and compared. With the assistance of principal component analysis (PCA), one can recognize patterns and identify groupings of differently treated samples. These methods could be important aids in efforts to conserve museum leather artifacts with unknown treatment methods and in the analysis of reindeer skin tanning processes. Copyright © 2016 John Wiley & Sons, Ltd.
PubMed ID
27654838 View in PubMed
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[1] Kotzebue infectious hepatitis epidemic. [2] Penicillin-resistant staph. Communicable Disease Bulletin 4, for week ending February 10, 1975.

https://arctichealth.org/en/permalink/ahliterature24
Source
Page 3 in Communicable Disease Bulletins 1975-1981.
Publication Type
Article
Date
1982
Source
Page 3 in Communicable Disease Bulletins 1975-1981.
Date
1982
Language
English
Geographic Location
U.S.
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
Kotzebue
Barrow
Bethel
Epidemics
Staphylococcus spp.
Hepatitis A
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 1903.
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1st Pan-Arctic Climate Outlook Forum, Ottawa, Canada, May 15-16, 2018.

https://arctichealth.org/en/permalink/ahliterature297018
Source
Eskimo Walrus Commission. 15 slides.
Publication Type
Report
Date
2018
  1 document  
Author
Metcalf, Vera K.
Author Affiliation
Eskimo Walrus Commission
Source
Eskimo Walrus Commission. 15 slides.
Date
2018
Language
English
Geographic Location
U.S.
Publication Type
Report
File Size
1733534
Keywords
Alaska
Pacfic walrus
Conservation
Hunting
Documents

6-EWC_PARCOF1-PresMay2018.pdf

Read PDF Online Download PDF
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1-year patient statistics in K�¤larne with diagnosis and remission registration at the medical centre

https://arctichealth.org/en/permalink/ahliterature276239

A 1-Year Quantitative Survey of Noro-, Adeno-, Human Boca-, and Hepatitis E Viruses in Raw and Secondarily Treated Sewage from Two Plants in Norway.

https://arctichealth.org/en/permalink/ahliterature272273
Source
Food Environ Virol. 2015 Sep;7(3):213-23
Publication Type
Article
Date
Sep-2015
Author
M. Myrmel
H. Lange
E. Rimstad
Source
Food Environ Virol. 2015 Sep;7(3):213-23
Date
Sep-2015
Language
English
Publication Type
Article
Keywords
Adenoviridae - classification - genetics - isolation & purification
Environmental monitoring
Genotype
Hepatitis E virus - classification - genetics - isolation & purification
Human bocavirus - classification - genetics - isolation & purification
Humans
Molecular Sequence Data
Norovirus - classification - genetics - isolation & purification
Norway
Phylogeny
Seasons
Sewage - virology
Water Pollution
Water Purification - instrumentation
Abstract
A study of enteric viruses in raw and treated sewage from two secondary treatment plants, which received sewage from Oslo city (plant A) and small municipalities in Hedmark county in Norway (plant B), showed high levels of noro-, adeno-, and bocavirus throughout the year. A seasonal variation was observed for adeno- and GII norovirus with higher levels during winter and bocavirus that had more positive samples during winter. The virus concentrations in raw sewage were comparable in the two plants, with medians (log10 genome copies per liter) of 6.1, 6.3, 6.0, and 4.5 for noro GI, noro GII, adeno-, and bocavirus, respectively. The level of hepatitis E virus was not determined as it was below the limit of quantification. The mean log10 virus reduction was 0.55 (plant A) and 1.44 (plant B) with the highest reduction found in the plant with longer hydraulic retention time. The adenoviruses were dominantly serotype 41, while serotype 12 appeared sporadically. Of the 102 raw and treated sewage samples that were tested, eight were positive for hepatitis E virus of which four were from treated sewage. Two of the four obtained gene sequences from hepatitis E virus originated from the rural sewage samples and showed high similarity with a genotype 3 strain of hepatitis E virus detected in local piglets. Two other hepatitis E virus sequences obtained from urban sewage samples showed high similarities with genotype 3 strains isolated from urban sewage in Spain and a human genotype 1 isolate from India. The study gives information on the levels of noroviruses in raw and treated sewage, which is valuable to risk assessment, information indicating that some infections with hepatitis E viruses in Norway have a regional origin and that human bocavirus 2 and 3 are prevalent in the Norwegian population.
PubMed ID
26003323 View in PubMed
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2, 3-diphosphoglycerate mutase: its demonstration by electrophoresis and the detection of a genetic variant.

https://arctichealth.org/en/permalink/ahliterature503
Source
Biochemical Genetics. 5:481-486.
Publication Type
Article
Date
1971
Author
Chen, S.-H.
Anderson, J.E.
Giblett, E.R.
Author Affiliation
King County Central Blood Bank (Seattle)
Source
Biochemical Genetics. 5:481-486.
Date
1971
Language
English
Geographic Location
Canada
Publication Type
Article
Physical Holding
Alaska Medical Library
Keywords
2,3-diphosphoglycerate mutase
Genetic variations
Plasma electrophoresis
Notes
From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 1326.
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3D Laparoscopy in Neonates and Infants.

https://arctichealth.org/en/permalink/ahliterature277898
Source
J Laparoendosc Adv Surg Tech A. 2016 Dec;26(12):1021-1027
Publication Type
Article
Date
Dec-2016
Author
Yury Kozlov
Konstantin Kovalkov
Vladimir Nowogilov
Source
J Laparoendosc Adv Surg Tech A. 2016 Dec;26(12):1021-1027
Date
Dec-2016
Language
English
Publication Type
Article
Abstract
This study focuses on the successful application of three-dimensional (3D) laparoscopic surgeries in the treatment of congenital anomalies and acquired diseases in the young pediatric population. The purpose of this scientific work consists in highlighting the spectrum, indications, applicability, and effectiveness of 3D endosurgery in children.
Our experience is based on 110 endosurgical procedures performed in neonates and infants in the 3D format between January 2014 and May 2015. Depending on the type of operations, all patients were divided into the following groups: (1) inguinal herniorrhaphy (IH)-63 patients; (2) Nissen fundoplication (NF)-22 patients; (3) pyeloureteral anastomosis (PUA)-15 patients; (4) nephrectomy (NE)-5 patients; and (5) ovarian cystectomy (OC)-5 patients. The patients of the first three groups were compared with babies who underwent standard laparoscopic surgery, performed in the two-dimensional (2D) format during the same time period. The groups were organized according to patient demographics, operative report, and postoperative parameters.
The patients were similar in terms of demographics and other preoperative parameters. There were significant differences in mean operative time between 3D and 2D procedures in the groups of patients with hydronephrosis and gastroesophageal reflux, which used manipulation with internal sutures (NF-37.95 minutes versus 48.42 minutes, P?=?.014; PUA-61.31 minutes versus 78.75 minutes, P?=?.019), but not in group after IH (15.88 minutes versus 15.57 minutes, P?=?.681). Postoperative parameters such as length of hospital stay and the number of complications were equivalent between groups.
In this study, we demonstrated the success of 3D laparoscopy in small babies with inguinal hernia, gastroesophageal reflux, hydronephrosis, ovarian cyst, and multicystic kidney. Laparoscopy in 3D format lessens the duration of complex procedures, which utilize the use of the suture technique into the abdominal cavity. The perception of depth and the presence of tactile feedback make 3D laparoscopic surgery more acceptable when compared to traditional laparoscopy.
PubMed ID
27926352 View in PubMed
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(3)H activity comparison between FTMC, VNIIM and LNE-LNHB.

https://arctichealth.org/en/permalink/ahliterature278451
Source
Appl Radiat Isot. 2016 Mar;109:41-3
Publication Type
Article
Date
Mar-2016
Author
Philippe Cassette
Paulius Butkus
Arunas Gudelis
Tatiana Shilnikova
Source
Appl Radiat Isot. 2016 Mar;109:41-3
Date
Mar-2016
Language
English
Publication Type
Article
Keywords
France
Internationality
Laboratories - standards
Lithuania
Nuclear Medicine - standards
Radiation Dosage
Radiometry - standards
Reference Values
Reproducibility of Results
Russia
Scintillation Counting
Sensitivity and specificity
Tritium - analysis - standards
Abstract
An activity comparison of tritiated water was organized in 2013 between 3 laboratories: FTMC (Lithuania), LNE-LNHB (France) and VNIIM (Russia). The solution was prepared by LNHB and ampoules were sent to the others laboratories. This solution was standardized in terms of activity per unit mass by participant laboratories using the Triple to Double Coincidence Ratio (TDCR) method in liquid scintillation counting (LSC). The tritiated water solution is traceable to the solution prepared by LNHB for the CCRI(II)-K2.H-3 2009 (3)H international comparison.
PubMed ID
26651170 View in PubMed
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3'-UTR poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer with nearly perfect sensitivity.

https://arctichealth.org/en/permalink/ahliterature273744
Source
Fam Cancer. 2015 Sep;14(3):449-53
Publication Type
Article
Date
Sep-2015
Author
Johanna Kondelin
Sari Tuupanen
Alexandra E Gylfe
Mervi Aavikko
Laura Renkonen-Sinisalo
Heikki Järvinen
Jan Böhm
Jukka-Pekka Mecklin
Claus L Andersen
Pia Vahteristo
Esa Pitkänen
Lauri A Aaltonen
Source
Fam Cancer. 2015 Sep;14(3):449-53
Date
Sep-2015
Language
English
Publication Type
Article
Keywords
3' Untranslated Regions
Calmodulin-Binding Proteins - genetics
Colorectal Neoplasms - genetics
Denmark
Finland
Humans
Microsatellite Instability
Polyribonucleotides - genetics
RNA-Binding Proteins - genetics
Repetitive Sequences, Nucleic Acid
Abstract
Approximately 15% of colorectal cancers exhibit instability of short nucleotide repeat regions, microsatellites. These tumors display a unique clinicopathologic profile and the microsatellite instability status is increasingly used to guide clinical management as it is known to predict better prognosis as well as resistance to certain chemotherapeutics. A panel of five repeats determined by the National Cancer Institute, the Bethesda panel, is currently the standard for determining the microsatellite instability status in colorectal cancer. Recently, a quasimonomorphic mononucleotide repeat 16T/U at the 3' untranslated region of the Ewing sarcoma breakpoint region 1 gene was reported to show perfect sensitivity and specificity in detecting mismatch repair deficient colorectal, endometrial, and gastric cancers in two independent populations. To confirm this finding, we replicated the analysis in 213 microsatellite unstable colorectal cancers from two independent populations, 148 microsatellite stable colorectal cancers, and the respective normal samples by PCR and fragment analysis. The repeat showed nearly perfect sensitivity for microsatellite unstable colorectal cancer as it was altered in 212 of the 213 microsatellite unstable (99.5%) and none of the microsatellite stable colorectal tumors. This repeat thus represents the first potential single marker for detecting microsatellite instability.
PubMed ID
25930744 View in PubMed
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A 3-year follow-up after anterior colporrhaphy compared with collagen-coated transvaginal mesh for anterior vaginal wall prolapse: a randomised controlled trial.

https://arctichealth.org/en/permalink/ahliterature272920
Source
BJOG. 2016 Jan;123(1):136-42
Publication Type
Article
Date
Jan-2016
Author
M. Rudnicki
E. Laurikainen
R. Pogosean
I. Kinne
U. Jakobsson
P. Teleman
Source
BJOG. 2016 Jan;123(1):136-42
Date
Jan-2016
Language
English
Publication Type
Article
Keywords
Collagen
Denmark - epidemiology
Dyspareunia - epidemiology - etiology
Female
Finland - epidemiology
Follow-Up Studies
Gynecologic Surgical Procedures - instrumentation - methods
Humans
Norway - epidemiology
Pelvic Organ Prolapse - epidemiology - surgery
Prospective Studies
Quality of Life
Surgical Mesh
Surveys and Questionnaires
Sweden - epidemiology
Treatment Outcome
Vagina - surgery
Abstract
To compare the 1-year (previously published) and 3-year objective and subjective cure rates, and complications, related to the use of a collagen-coated transvaginal mesh for anterior vaginal wall prolapse against a conventional anterior repair.
Randomised controlled study.
Six departments of obstetrics and gynaecology in Norway, Sweden, Finland, and Denmark.
A total of 138 women, of 55 years of age or older, admitted for stage =2 anterior vaginal wall prolapse.
The women scheduled for primary anterior vaginal wall prolapse surgery were randomised between conventional anterior colporrhaphy and surgery with a collagen-coated prolene mesh. All patients were evaluated using the Pelvic Organ Prolapse Quantification (POP-Q) assessment before and after surgery. Symptoms related to pelvic organ prolapse were evaluated using the Pelvic Floor Impact Questionnaire (PFIQ-7) and the Pelvic Floor Distress Inventory (PFDI-20).
Objective cure, defined as POP-Q stage
PubMed ID
26420345 View in PubMed
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A 3-year follow-up study of Swedish youths committed to juvenile institutions: Frequent occurrence of criminality and health care use regardless of drug abuse.

https://arctichealth.org/en/permalink/ahliterature288173
Source
Int J Law Psychiatry. 2017 Jan - Feb;50:52-60
Publication Type
Article
Author
Ola Ståhlberg
Sofia Boman
Christina Robertsson
Nóra Kerekes
Henrik Anckarsäter
Thomas Nilsson
Source
Int J Law Psychiatry. 2017 Jan - Feb;50:52-60
Language
English
Publication Type
Article
Keywords
Adolescent
Attention Deficit Disorder with Hyperactivity - diagnosis - epidemiology - psychology
Comorbidity
Crime - legislation & jurisprudence - statistics & numerical data
Cross-Sectional Studies
Female
Follow-Up Studies
Health Services - legislation & jurisprudence - utilization
Humans
Juvenile Delinquency - legislation & jurisprudence - psychology - statistics & numerical data
Male
Outcome Assessment (Health Care) - statistics & numerical data
Recurrence
Residential Treatment - legislation & jurisprudence - statistics & numerical data
Risk factors
Substance-Related Disorders - diagnosis - epidemiology - psychology
Sweden
Violence - legislation & jurisprudence - prevention & control - psychology
Young Adult
Abstract
This 3-year follow-up study compares background variables, extent of criminality and criminal recidivism in the form of all court convictions, the use of inpatient care, and number of early deaths in Swedish institutionalized adolescents (N=100) with comorbid substance use disorders (SUD) and Attention-Deficit/Hyperactivity Disorder (ADHD) (n=25) versus those with SUD but no ADHD (n=30), and those without SUD (n=45). In addition it aims to identify whether potential risk factors related to these groups are associated with persistence in violent criminality. Results showed almost no significant differences between the three diagnostic groups, but the SUD plus ADHD group displayed a somewhat more negative outcome with regard to criminality, and the non-SUD group stood out with very few drug related treatment episodes. However, the rate of criminal recidivism was strikingly high in all three groups, and the use of inpatient care as well as the number of untimely deaths recorded in the study population was dramatically increased compared to a age matched general population group. Finally, age at first conviction emerged as the only significant predictor of persistence in violent criminality with an AUC of .69 (CI (95%) .54-.84, p=.02). Regardless of whether SUD, with or without ADHD, is at hand or not, institutionalized adolescents describe a negative course with extensive criminality and frequent episodes of inpatient treatment, and thus requires a more effective treatment than present youth institutions seem to offer today. However, the few differences found between the three groups, do give some support that those with comorbid SUD and ADHD have the worst prognosis with regard to criminality, health, and untimely death, and as such are in need of even more extensive treatment interventions.
PubMed ID
27745884 View in PubMed
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A 4 year prospective longitudinal study of progression of dental erosion associated to lifestyle in 13-14 year-old Swedish adolescents.

https://arctichealth.org/en/permalink/ahliterature282697
Source
J Dent. 2016 Apr;47:55-62
Publication Type
Article
Date
Apr-2016
Author
Agneta Hasselkvist
Anders Johansson
Ann-Katrin Johansson
Source
J Dent. 2016 Apr;47:55-62
Date
Apr-2016
Language
English
Publication Type
Article
Keywords
Adolescent
Animals
Dental Caries - epidemiology - pathology
Dental Plaque - epidemiology - pathology
Female
Gingivitis - epidemiology - pathology
Humans
Life Style
Longitudinal Studies
Male
Prevalence
Prospective Studies
Sex Factors
Surveys and Questionnaires
Sweden - epidemiology
Tooth Erosion - epidemiology - pathology
Abstract
To evaluate the progression of dental erosion in 13-14 year-olds after 4 years, and its association with lifestyle and oral health.
227 randomly selected 13-14 year-olds from a Public Dental Clinic, Örebro, Sweden, were investigated. A clinical examination was performed which included dental caries/gingival/plaque status, as well as grading of dental erosion at the tooth surface and participant levels in "marker teeth", including buccal/palatal surfaces of 6 maxillary anterior teeth (13-23), and occlusal surfaces of first molars. An interview and a questionnaire regarding drinking habits and other lifestyle factors were completed. All investigations were repeated at follow-up. The participants were divided into high and low progression erosion groups and logistic regression statistics were applied.
175 individuals participated at follow-up. Progression occurred in 35% of the 2566 tooth surfaces. 32% of the surfaces had deteriorated by one severity grade (n=51 individuals) and 3% by two grades (n=2 individuals). Boys showed more severe erosion than girls at the follow-up. Among the variables predicting greater progression, a lower severity of erosive wear at baseline had the highest OR (13.3), followed in descending order by a "retaining" drinking technique, more frequent intake of drinks between meals, low GBI and lesser sour milk intake, with reference to the baseline recording. Using these five variables, sensitivity and specificity were 87% and 67% respectively, for predicting progression of erosion.
Progression of erosive lesions in Swedish adolescents aged 13-14 years followed up to age 17-18 years was common and related to certain lifestyle factors.
In permanent teeth, dental erosion may develop early in life and its progression is common. Dental health workers should be made aware of this fact and regular screenings for erosion and recording of associated lifestyle factors should be performed.
PubMed ID
26867982 View in PubMed
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5-Alpha reductase inhibitor use and prostate cancer survival in the Finnish Prostate Cancer Screening Trial.

https://arctichealth.org/en/permalink/ahliterature275383
Source
Int J Cancer. 2016 Jun 15;138(12):2820-8
Publication Type
Article
Date
Jun-15-2016
Author
Teemu J Murtola
Elina K Karppa
Kimmo Taari
Kirsi Talala
Teuvo L J Tammela
Anssi Auvinen
Source
Int J Cancer. 2016 Jun 15;138(12):2820-8
Date
Jun-15-2016
Language
English
Publication Type
Article
Keywords
5-alpha Reductase Inhibitors - therapeutic use
Aged
Antineoplastic Agents - therapeutic use
Early Detection of Cancer
Finland - epidemiology
Humans
Kaplan-Meier Estimate
Male
Mass Screening
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Prostatic Neoplasms - diagnosis - drug therapy - mortality
Abstract
Randomized clinical trials have shown that use of 5a-reductase inhibitors (5-ARIs) lowers overall prostate cancer (PCa) risk compared to placebo, while the proportion of Gleason 8-10 tumors is elevated. It is unknown whether this affects PCa-specific survival. We studied disease-specific survival by 5-ARI usage in a cohort of 6,537 prostate cancer cases diagnosed in the Finnish Prostate Cancer Screening Trial and linked to the national prescription database for information on medication use. Cox proportional hazards regression was used to estimate hazard ratios and 95% confidence intervals for prostate cancer-specific deaths. For comparison, survival among alpha-blocker users was also evaluated. During the median follow-up of 7.5 years after diagnosis a total of 2,478 men died; 617 due to prostate cancer and 1,861 due to other causes. The risk of prostate cancer death did not differ between 5-ARI users and nonusers (multivariable adjusted HR 0.94, 95% CI 0.72-1.24 and HR 0.98, 95% CI 0.69-1.41 for usage before and after the diagnosis, respectively). Alpha-blocker usage both before and after diagnosis was associated with increased risk of prostate cancer death (HR 1.29, 95% CI 1.08-1.54 and HR 1.56, 95% CI 1.30-1.86, respectively). The risk increase vanished in long-term alpha-blocker usage. Use of 5-ARIs does not appear to affect prostate cancer mortality when used in management of benign prostatic hyperplasia. Increased risk associated with alpha-blocker usage should prompt further exploration on the prognostic role of lower urinary tract symptoms.
PubMed ID
26804670 View in PubMed
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5-Aminolevulinic acid in intraoperative photodynamic therapy of bladder cancer (results of multicenter trial).

https://arctichealth.org/en/permalink/ahliterature281149
Source
Photodiagnosis Photodyn Ther. 2016 Dec;16:106-109
Publication Type
Article
Date
Dec-2016
Author
E V Filonenko
A D Kaprin
B Y A Alekseev
O I Apolikhin
E K Slovokhodov
V I Ivanova-Radkevich
A N Urlova
Source
Photodiagnosis Photodyn Ther. 2016 Dec;16:106-109
Date
Dec-2016
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aminolevulinic Acid - administration & dosage
Combined Modality Therapy - methods
Cystectomy - methods
Female
Humans
Male
Middle Aged
Neoplasm Invasiveness
Photochemotherapy - methods
Photosensitizing Agents - administration & dosage
Russia
Treatment Outcome
Urinary Bladder Neoplasms - diagnosis - pathology - therapy
Abstract
The results of multicenter prospective trial for efficacy of combined modality treatment: transurethral resection (TUR)+photodynamic therapy (PDT) with alasens for bladder cancer are represented in the article. Trials were organized by Research Institute of Organic Intermediates and Dyes and conducted according to clinical protocol approved by Ministry of Health of Russia, at the sites of leading Russian cancer clinical centers. The trial included 45 subjects with verified diagnosis of non-muscle-invasive bladder cancer. Patients underwent TUR of bladder with simultaneous PDT as anti-relapse treatment. Alasens was administered to patients as intravesicular instillation of 3% solution in volume of 50ml with 1.5-2h exposure (prior to TUR). TUR was performed after instillation. PDT session was conducted immediately after the completion of TUR on a single occasion by means of combined local irradiation on tumor bed with diffuse irradiation on whole urinary bladder mucosa (light dose of local irradiation - 100J/cm2, diffuse irradiation - 20J/cm2). Good tolerance of the treatment was noticed, there were no complications. Among 45 patients included in the trial, 35 (78%) completed 12 month protocol follow-up without relapse. In our study PDT with alasens after TUR reported a recurrence rate of non-muscle-invasive bladder cancer for 1st year after treatment of 22%. TUR with intraoperative PDT with 5-aminolevulinic acid may offer an alternative in the treatment of non-muscle-invasive intermediate and high-risk bladder cancer.
PubMed ID
27671517 View in PubMed
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5-a reductase inhibitors, benign prostatic hyperplasia, and risk of male breast cancer.

https://arctichealth.org/en/permalink/ahliterature271757
Source
Cancer Causes Control. 2015 Sep;26(9):1289-97
Publication Type
Article
Date
Sep-2015
Author
Robinson D
Garmo H
Holmberg L
Stattin P
Source
Cancer Causes Control. 2015 Sep;26(9):1289-97
Date
Sep-2015
Language
English
Publication Type
Article
Keywords
5-alpha Reductase Inhibitors - adverse effects - therapeutic use
Adrenergic alpha-Antagonists - adverse effects - therapeutic use
Aged
Aged, 80 and over
Breast Neoplasms, Male - chemically induced - pathology
Cohort Studies
Humans
Male
Middle Aged
Prostatic Hyperplasia - drug therapy - pathology
Risk
Sweden
Abstract
5-a reductase inhibitors (5-ARI) have been suggested to increase the risk of male breast cancer. The aim of this study was to study the risk of breast cancer in men on 5-ARI, in men with benign prostatic hyperplasia (BPH) not on 5-ARI, and in men without BPH.
We performed a population-based cohort study in Sweden with data from The Prescribed Drug Register, The Patient Register, and The Cancer Register. Men on 5-ARI, men on a-blockers, or men who had undergone a transurethral resection of the prostate (TUR-P) prior to or during 2006-2008 were included as exposed to BPH and a specific treatment thereof. For each exposed man, five unexposed men were selected. Risk of breast cancer was calculated in Cox proportional hazard models.
There were 124,183 exposed men and 545,293 unexposed men, and during follow-up (median 6 years), 99 men with breast cancer were diagnosed. Compared to unexposed men, men on 5-ARI had a hazard ratio (HR) of breast cancer of 0.74 (95% confidence interval (CI) 0.27-2.03), men on a-blockers had HR 1.47 (95% CI 0.73-2.95), and men with a TUR-P had HR 1.99 (95% CI 1.05-3.75).
No increased risk of breast cancer was observed for men on 5-ARI. However, the increased risk of breast cancer among men who had undergone a TUR-P, a strong indicator of BPH, suggests that the endocrine milieu conducive to BPH is associated with male breast cancer.
Notes
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PubMed ID
26109464 View in PubMed
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5th Western Alaska Interdisciplinary Science Conference and Forum (2012) : "Resilience in a changing world". [Abstract book]

https://arctichealth.org/en/permalink/ahliterature297025
Source
Western Alaska Interdisciplinary Science Conference Forum 2012. UAF Bristol Bay Campus, Dillingham, Alaska, March 28-31, 2012. 50 p.
Publication Type
Conference/Meeting Material
Date
2012
  1 document  
Source
Western Alaska Interdisciplinary Science Conference Forum 2012. UAF Bristol Bay Campus, Dillingham, Alaska, March 28-31, 2012. 50 p.
Date
2012
Language
English
Geographic Location
U.S.
Publication Type
Conference/Meeting Material
File Size
3624398
Keywords
Alaska
Fisheries
Marine science
Traditional knowledge
Subsistence
Sustainable energy
Waste disposal
Food security
Ecosystems
Education
Documents
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A 5-year follow-up study of users of benzodiazepine: starting with diazepam versus oxazepam.

https://arctichealth.org/en/permalink/ahliterature282849
Source
Br J Gen Pract. 2016 Apr;66(645):e241-7
Publication Type
Article
Date
Apr-2016
Author
Ingunn Fride Tvete
Trine Bjørner
Tor Skomedal
Source
Br J Gen Pract. 2016 Apr;66(645):e241-7
Date
Apr-2016
Language
English
Publication Type
Article
Keywords
Adult
Anti-Anxiety Agents - therapeutic use
Anxiety - drug therapy - epidemiology
Depression - drug therapy - epidemiology
Diazepam - therapeutic use
Dose-Response Relationship, Drug
Drug Prescriptions - statistics & numerical data
Female
Follow-Up Studies
Humans
Male
Middle Aged
Norway - epidemiology
Oxazepam - therapeutic use
Prescription Drug Misuse - statistics & numerical data
Prevalence
Proportional Hazards Models
Risk factors
Substance-Related Disorders - epidemiology
Abstract
Drug dependency may develop during long-term benzodiazepine use, indicated, for example, by dose escalation. The first benzodiazepine chosen may affect the risk of dose escalation.
To detect possible differences in benzodiazepine use between new users of diazepam and oxazepam over time.
This 5-year prescription database study included 19 747 new benzodiazepine users, inhabitants of Norway, aged 30-60 years, with first redemption for diazepam or oxazepam.
Individuals starting on diazepam versus oxazepam were analysed by logistic regression with sex, age, other drug redemptions, prescriber's specialty, household income, education level, type of work, and vocational rehabilitation support as background variables. Time to reach a daily average intake of =1 defined daily doses (DDD) over a 3-month period was analysed using a Cox proportional hazard regression model.
New users of oxazepam had a higher risk for dose escalation compared with new users of diazepam. This was true even when accounting for differences in sociodemographic status and previous drug use (hazard ratio [HR] 1.33, 95% confidence interval = 1.17 to 1.51).
Most doctors prescribed, according to recommendations, oxazepam to individuals they may have regarded as prone to and at risk of dependency. However, these individuals were at higher risk for dose escalation even when accounting for differences in sociodemographic status and previous drug use. Differences between the two user groups could be explained by different preferences for starting drug, DDD for oxazepam being possibly too low, and some unaccounted differences in illness.
Notes
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PubMed ID
26965028 View in PubMed
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